The ability to quickly and accurately compute properties from atomic simulations is critical for advancing a large number of applications in chemistry and materials science including drug discovery, energy storage, and semiconductor manufacturing. To address this need, we present a family of Universal Models for Atoms (UMA), designed to push the frontier of speed, accuracy, and generalization. UMA models are trained on half a billion unique 3D atomic structures (the largest training runs to date) by compiling data across multiple chemical domains, e.g.

Probabilistic models for binary spike patterns provide a powerful tool for understanding the statistical dependencies in large-scale neural recordings. Maximum entropy (or maxent'') models, which seek to explain dependencies in terms of low-order interactions between neurons, have enjoyed remarkable success in modeling such patterns, particularly for small groups of neurons. However, these models are computationally intractable for large populations, and low-order maxent models have been shown to be inadequate for some datasets. To overcome these limitations, we propose a family of "universal'' models for binary spike patterns, where universality refers to the ability to model arbitrary distributions over all 2 m binary patterns. We construct universal models using a Dirichlet process centered on a well-behaved parametric base measure, which naturally combines the flexibility of a histogram and the parsimony of a parametric model. We derive computationally efficient inference methods using Bernoulli and cascade-logistic base measures, which scale tractably to large populations. We also establish a condition for equivalence between the cascade-logistic and the 2nd-order maxent or "Ising'' model, making cascade-logistic a reasonable choice for base measure in a universal model.

Accurate International Classification of Diseases (ICD) coding is critical for clinical documentation, billing, and healthcare analytics, yet it remains a labour-intensive and error-prone task. Although large language models (LLMs) show promise in automating ICD coding, their challenges in base model selection, input contextualization, and training data redundancy limit their effectiveness. We propose a modular framework for ICD-10 Clinical Modification (ICD-10-CM) code prediction that addresses these challenges through principled model selection, redundancy-aware data sampling, and structured input design. The framework integrates an LLM-as-judge evaluation protocol with Plackett-Luce aggregation to assess and rank open-source LLMs based on their intrinsic comprehension of ICD-10-CM code definitions. We introduced embedding-based similarity measures, a redundancy-aware sampling strategy to remove semantically duplicated discharge summaries. We leverage structured discharge summaries from Taiwanese hospitals to evaluate contextual effects and examine section-wise content inclusion under universal and section-specific modelling paradigms. Experiments across two institutional datasets demonstrate that the selected base model after fine-tuning consistently outperforms baseline LLMs in internal and external evaluations. Incorporating more clinical sections consistently improves prediction performance. This study uses open-source LLMs to establish a practical and principled approach to ICD-10-CM code prediction. The proposed framework provides a scalable, institution-ready solution for real-world deployment of automated medical coding systems by combining informed model selection, efficient data refinement, and context-aware prompting.

For transradial amputees, robotic prosthetic hands promise to regain the capability to perform daily living activities. To advance next-generation prosthetic hand control design, it is crucial to address current shortcomings in robustness to out of lab artifacts, and generalizability to new environments. Due to the fixed number of object to interact with in existing datasets, contrasted with the virtually infinite variety of objects encountered in the real world, current grasp models perform poorly on unseen objects, negatively affecting users' independence and quality of life. To address this: (i) we define semantic projection, the ability of a model to generalize to unseen object types and show that conventional models like YOLO, despite 80% training accuracy, drop to 15% on unseen objects. (ii) we propose Grasp-LLaVA, a Grasp Vision Language Model enabling human-like reasoning to infer the suitable grasp type estimate based on the object's physical characteristics resulting in a significant 50.2% accuracy over unseen object types compared to 36.7% accuracy of an SOTA grasp estimation model. Lastly, to bridge the performance-latency gap, we propose Hybrid Grasp Network (HGN), an edge-cloud deployment infrastructure enabling fast grasp estimation on edge and accurate cloud inference as a fail-safe, effectively expanding the latency vs. accuracy Pareto. HGN with confidence calibration (DC) enables dynamic switching between edge and cloud models, improving semantic projection accuracy by 5.6% (to 42.3%) with 3.5x speedup over the unseen object types. Over a real-world sample mix, it reaches 86% average accuracy (12.2% gain over edge-only), and 2.2x faster inference than Grasp-LLaVA alone.

One-shot medical landmark detection gains much attention and achieves great success for its label-efficient training process. However, existing one-shot learning methods are highly specialized in a single domain and suffer domain preference heavily in the situation of multi-domain unlabeled data. Moreover, one-shot learning is not robust that it faces performance drop when annotating a sub-optimal image. To tackle these issues, we resort to developing a domain-adaptive one-shot landmark detection framework for handling multi-domain medical images, named Universal One-shot Detection (UOD) . UOD consists of two stages and two corresponding universal models which are designed as combinations of domain-specific modules and domain-shared modules. In the first stage, a domain-adaptive convolution model is self-supervised learned to generate pseudo landmark labels. In the second stage, we design a domain-adaptive transformer to eliminate domain preference and build the global context for multi-domain data. Even though only one annotated sample from each domain is available for training, the domain-shared modules help UOD aggregate all one-shot samples to detect more robust and accurate landmarks. We investigated both qualitatively and quantitatively the proposed UOD on three widely-used public X-ray datasets in different anatomical domains (i.e., head, hand, chest) and obtained state-of-the-art performances in each domain.

Purpose: This commentary introduces how artificial intelligence (AI) can be leveraged to advance cross-language intelligibility assessment of dysarthric speech. Method: We propose a conceptual framework consisting of a universal model that captures language-universal speech impairments and a language-specific intelligibility model that incorporates linguistic nuances. Additionally, we identify key barriers to cross-language intelligibility assessment, including data scarcity, annotation complexity, and limited linguistic insights, and present AI-driven solutions to overcome these challenges. Conclusion: Advances in AI offer transformative opportunities to enhance cross-language intelligibility assessment for dysarthric speech by balancing scalability across languages and adaptability by languages.

The integration of deep learning in medical imaging has shown great promise for enhancing diagnostic, therapeutic, and research outcomes. However, applying universal models across multiple modalities remains challenging due to the inherent variability in data characteristics. This study aims to introduce and evaluate a Modality Projection Universal Model (MPUM). MPUM employs a novel modality-projection strategy, which allows the model to dynamically adjust its parameters to optimize performance across different imaging modalities. The MPUM demonstrated superior accuracy in identifying anatomical structures, enabling precise quantification for improved clinical decision-making. It also identifies metabolic associations within the brain-body axis, advancing research on brain-body physiological correlations. Furthermore, MPUM's unique controller-based convolution layer enables visualization of saliency maps across all network layers, significantly enhancing the model's interpretability.

Transformer-based models have revolutionized the field of natural language processing. To understand why they perform so well and to assess their reliability, several studies have focused on questions such as: Which linguistic properties are encoded by these models, and to what extent? How robust are these models in encoding linguistic properties when faced with perturbations in the input text? However, these studies have mainly focused on BERT and the English language. In this paper, we investigate similar questions regarding encoding capability and robustness for 8 linguistic properties across 13 different perturbations in 6 Indic languages, using 9 multilingual Transformer models (7 universal and 2 Indic-specific). To conduct this study, we introduce a novel multilingual benchmark dataset, IndicSentEval, containing approximately $\sim$47K sentences. Surprisingly, our probing analysis of surface, syntactic, and semantic properties reveals that while almost all multilingual models demonstrate consistent encoding performance for English, they show mixed results for Indic languages. As expected, Indic-specific multilingual models capture linguistic properties in Indic languages better than universal models. Intriguingly, universal models broadly exhibit better robustness compared to Indic-specific models, particularly under perturbations such as dropping both nouns and verbs, dropping only verbs, or keeping only nouns. Overall, this study provides valuable insights into probing and perturbation-specific strengths and weaknesses of popular multilingual Transformer-based models for different Indic languages. We make our code and dataset publicly available [https://tinyurl.com/IndicSentEval}].

Building machine learning models can be a time-consuming process that often takes several months to implement in typical business scenarios. To ensure consistent model performance and account for variations in data distribution, regular retraining is necessary. This paper introduces a solution for improving online customer service in e-commerce by presenting a universal model for predict-ing labels based on customer questions, without requiring training. Our novel approach involves using machine learning techniques to tag customer questions in transcripts and create a repository of questions and corresponding labels. When a customer requests assistance, an information retrieval model searches the repository for similar questions, and statistical analysis is used to predict the corresponding label. By eliminating the need for individual model training and maintenance, our approach reduces both the model development cycle and costs. The repository only requires periodic updating to maintain accuracy.