The Teacher Forcing algorithm trains recurrent networks by supplying observed sequence values as inputs during training and using the network's own one-stepahead predictions to do multi-step sampling. We introduce the Professor Forcing algorithm, which uses adversarial domain adaptation to encourage the dynamics of the recurrent network to be the same when training the network and when sampling from the network over multiple time steps. We apply Professor Forcing to language modeling, vocal synthesis on raw waveforms, handwriting generation, and image generation. Empirically we find that Professor Forcing acts as a regularizer, improving test likelihood on character level Penn Treebank and sequential MNIST. We also find that the model qualitatively improves samples, especially when sampling for a large number of time steps. This is supported by human evaluation of sample quality. Trade-offs between Professor Forcing and Scheduled Sampling are discussed. We produce T-SNEs showing that Professor Forcing successfully makes the dynamics of the network during training and sampling more similar.

Of course, the count function should be fixed.

Psychologists are interested in developing instructional policies that boost student learning. An instructional policy specifies the manner and content of instruction. For example, in the domain of concept learning, a policy might specify the nature of exemplars chosen over a training sequence. Traditional psychological studies compare several hand-selected policies, e.g., contrasting a policy that selects only difficult-to-classify exemplars with a policy that gradually progresses over the training sequence from easy exemplars to more difficult (known as {\em fading}). We propose an alternative to the traditional methodology in which we define a parameterized space of policies and search this space to identify the optimum policy.

Sequential data in our everyday life is often hierarchically structured.

Language models often struggle with cross-mode knowledge retrieval -- the ability to access knowledge learned in one format (mode) when queried in another. We demonstrate that models trained on multiple data sources (e.g., Wikipedia and TinyStories) exhibit significantly reduced accuracy when retrieving knowledge in a format different from its original training mode. This paper quantitatively investigates this phenomenon through a controlled study of random token sequence memorization across different modes. We first explore dataset rewriting as a solution, revealing that effective cross-mode retrieval requires prohibitively extensive rewriting efforts that follow a sigmoid-like relationship. As an alternative, we propose CASCADE, a novel pretraining algorithm that uses cascading datasets with varying sequence lengths and computing losses on only the second half of each training sequence to capture knowledge at different scales. Our experiments demonstrate that CASCADE outperforms dataset rewriting approaches, even when compressed into a single model with a unified loss function. This work provides both qualitative evidence of cross-mode retrieval limitations and a practical solution to enhance language models' ability to access knowledge independently of its presentational format.

Understanding and modeling enzyme-substrate interactions is crucial for catalytic mechanism research, enzyme engineering, and metabolic engineering. Although a large number of predictive methods have emerged, they do not incorporate prior knowledge of enzyme catalysis to rationally modulate general protein-molecule features that are misaligned with catalytic patterns. To address this issue, we introduce a two-stage progressive framework, OmniESI, for enzyme-substrate interaction prediction through conditional deep learning. By decomposing the modeling of enzyme-substrate interactions into a two-stage progressive process, OmniESI incorporates two conditional networks that respectively emphasize enzymatic reaction specificity and crucial catalysis-related interactions, facilitating a gradual feature modulation in the latent space from general protein-molecule domain to catalysis-aware domain. On top of this unified architecture, OmniESI can adapt to a variety of downstream tasks, including enzyme kinetic parameter prediction, enzyme-substrate pairing prediction, enzyme mutational effect prediction, and enzymatic active site annotation. Under the multi-perspective performance evaluation of in-distribution and out-of-distribution settings, OmniESI consistently delivered superior performance than state-of-the-art specialized methods across seven benchmarks. More importantly, the proposed conditional networks were shown to internalize the fundamental patterns of catalytic efficiency while significantly improving prediction performance, with only negligible parameter increases (0.16%), as demonstrated by ablation studies on key components. Overall, OmniESI represents a unified predictive approach for enzyme-substrate interactions, providing an effective tool for catalytic mechanism cracking and enzyme engineering with strong generalization and broad applicability.

Multimodal fusion is susceptible to modality imbalance, where dominant modalities overshadow weak ones, easily leading to biased learning and suboptimal fusion, especially for incomplete modality conditions. T o address this problem, we propose a Shapley-guided alternating training framework that adaptively prioritizes minor modalities to balance and thus enhance the fusion. Our method leverages Shapley V alue-based scheduling to improve the training sequence adaptively, ensuring that under-optimized modalities receive sufficient learning. Additionally, we introduce the memory module to refine and inherit modality-specific representations with a cross-modal mapping mechanism to align features at both the feature and sample levels. T o further validate the adaptability of the proposed approach, the encoder module empirically adopts both conventional and LLM-based backbones. With building up a novel mul-timodal equilibrium metric, namely, equilibrium deviation metric (EDM), we evaluate the performance in both balance and accuracy across four multimodal benchmark datasets, where our method achieves state-of-the-art (SOTA) results. Meanwhile, robustness analysis under missing modalities highlights its strong generalization capabilities. Accordingly, our findings reveal the untapped potential of alternating training, demonstrating that strategic modality priori-tization fundamentally balances and promotes multimodal learning, offering a new paradigm for optimizing multi-modal training dynamics.