Agentic AI systems, software agents with autonomy, decision-making ability, and adaptability, are increasingly used to execute complex tasks on behalf of organisations. Most such systems rely on Large Language Models (LLMs), whose broad semantic capabilities enable powerful language processing but lack explicit, institution-specific grounding. In enterprises, data rarely comes with an inspectable semantic layer, and constructing one typically requires labour-intensive "data archaeology": cleaning, modelling, and curating knowledge into ontologies, taxonomies, and other formal structures. At the same time, explainability methods such as saliency maps expose an "interpretability gap": they highlight what the model attends to but not why, leaving decision processes opaque. In this preprint, we present a case study, developed by Kaiasm and Avantra AI through their work with The Turing Way Practitioners Hub, a forum developed under the InnovateUK BridgeAI program. This study presents a collaborative human-AI approach to building an inspectable semantic layer for Agentic AI. AI agents first propose candidate knowledge structures from diverse data sources; domain experts then validate, correct, and extend these structures, with their feedback used to improve subsequent models. Authors show how this process captures tacit institutional knowledge, improves response quality and efficiency, and mitigates institutional amnesia. We argue for a shift from post-hoc explanation to justifiable Agentic AI, where decisions are grounded in explicit, inspectable evidence and reasoning accessible to both experts and non-specialists.

Brain tumors pose a significant global health challenge due to their high prevalence and mortality rates across all age groups. Detecting brain tumors at an early stage is crucial for effective treatment and patient outcomes. This study presents a comprehensive investigation into the use of Convolutional Neural Networks (CNNs) for brain tumor detection using Magnetic Resonance Imaging (MRI) images. The dataset, consisting of MRI scans from both healthy individuals and patients with brain tumors, was processed and fed into the CNN architecture. The SoftMax Fully Connected layer was employed to classify the images, achieving an accuracy of 98%. To evaluate the CNN's performance, two other classifiers, Radial Basis Function (RBF) and Decision Tree (DT), were utilized, yielding accuracy rates of 98.24% and 95.64%, respectively. The study also introduced a clustering method for feature extraction, improving CNN's accuracy. Sensitivity, Specificity, and Precision were employed alongside accuracy to comprehensively evaluate the network's performance. Notably, the SoftMax classifier demonstrated the highest accuracy among the categorizers, achieving 99.52% accuracy on test data. The presented research contributes to the growing field of deep learning in medical image analysis. The combination of CNNs and MRI data offers a promising tool for accurately detecting brain tumors, with potential implications for early diagnosis and improved patient care.

Dr. Marc Siegel discusses the pros and cons of using AI in health care and how it's too early to decide whether it's entirely reliable on on'Fox News Tonight.' For a small percentage of cancer patients, doctors are unable to determine where in the body the disease originated. To help pinpoint the origin of the cancers of unknown primary (CUP), researchers at the Massachusetts Institute of Technology (MIT) have created an artificial intelligence model that analyzes the patient's genetic information -- and predicts where the tumor first appeared. When using the new AI model for 900 patients with cancers of unknown origin, researchers found that they could accurately classify at least 40% of tumors, according to a study published in Nature Medicine. WHAT IS ARTIFICIAL INTELLIGENCE (AI)?