Supervised deep-learning (SDL) techniques with paired training datasets have been widely studied for X-ray computed tomography (CT) image reconstruction. However, due to the difficulties of obtaining paired training datasets in clinical routine, the SDL methods are still away from common uses in clinical practices. In recent years, self-supervised deep-learning (SSDL) techniques have shown great potential for the studies of CT image reconstruction. In this work, we propose a self-supervised cross-task mutual learning (SS-CTML) framework for CT image reconstruction. Specifically, a sparse-view scanned and a limited-view scanned sinogram data are first extracted from a full-view scanned sinogram data, which results in three individual reconstruction tasks, i.e., the full-view CT (FVCT) reconstruction, the sparse-view CT (SVCT) reconstruction, and limited-view CT (LVCT) reconstruction. Then, three neural networks are constructed for the three reconstruction tasks. Considering that the ultimate goals of the three tasks are all to reconstruct high-quality CT images, we therefore construct a set of cross-task mutual learning objectives for the three tasks, in which way, the three neural networks can be self-supervised optimized by learning from each other. Clinical datasets are adopted to evaluate the effectiveness of the proposed framework. Experimental results demonstrate that the SS-CTML framework can obtain promising CT image reconstruction performance in terms of both quantitative and qualitative measurements.

Reconstructing images using Computed Tomography (CT) in an industrial context leads to specific challenges that differ from those encountered in other areas, such as clinical CT. Indeed, non-destructive testing with industrial CT will often involve scanning multiple similar objects while maintaining high throughput, requiring short scanning times, which is not a relevant concern in clinical CT. Under-sampling the tomographic data (sinograms) is a natural way to reduce the scanning time at the cost of image quality since the latter depends on the number of measurements. In such a scenario, post-processing techniques are required to compensate for the image artifacts induced by the sinogram sparsity. We introduce the Self-supervised Denoiser Framework (SDF), a self-supervised training method that leverages pre-training on highly sampled sinogram data to enhance the quality of images reconstructed from undersampled sinogram data. The main contribution of SDF is that it proposes to train an image denoiser in the sinogram space by setting the learning task as the prediction of one sinogram subset from another. As such, it does not require ground-truth image data, leverages the abundant data modality in CT, the sinogram, and can drastically enhance the quality of images reconstructed from a fraction of the measurements. We demonstrate that SDF produces better image quality, in terms of peak signal-to-noise ratio, than other analytical and self-supervised frameworks in both 2D fan-beam or 3D cone-beam CT settings. Moreover, we show that the enhancement provided by SDF carries over when fine-tuning the image denoiser on a few examples, making it a suitable pre-training technique in a context where there is little high-quality image data. Our results are established on experimental datasets, making SDF a strong candidate for being the building block of foundational image-enhancement models in CT.

An artificial intelligence (AI) algorithm can transform low-dose CT (LDCT) scans into high-quality exams that radiologists may even prefer over LDCT studies produced via commercial iterative reconstruction techniques (Nature Machine Intelligence 10.1038/s42256-019-0057-9). A team of researchers from Rensselaer Polytechnic Institute (RPI) in Troy, NY, and Massachusetts General Hospital (MGH) in Boston developed a deep-learning model called a modularized adaptive processing neural network (MAP-NN), which progressively reduces noise on LDCT images with guidance from the radiologist until the optimal level of image quality is achieved. Testing on images from three different vendors, three radiologists found the algorithm produced images that were either better or comparable to images processed with iterative reconstruction. The deep-learning method also processed images much faster. "The deep-learning approach can thus already effectively compete with iterative reconstruction solutions and potentially replace the iterative reconstruction approach," wrote the group, led by Hongming Shan of RPI.

In sparse-view Computed Tomography (CT), only a small number of projection images are taken around the object, and sinogram interpolation method has a significant impact on final image quality. When the amount of sparsity (the amount of missing views in sinogram data) is not high, conventional interpolation methods have yielded good results. When the amount of sparsity is high, more advanced sinogram interpolation methods are needed. Recently, several deep learning (DL) based sinogram interpolation methods have been proposed. However, those DL-based methods have mostly tested so far on computer simulated sinogram data rather experimentally acquired sinogram data. In this study, we developed a sinogram interpolation method for sparse-view micro-CT based on the combination of U-Net and residual learning. We applied the method to sinogram data obtained from sparse-view micro-CT experiments, where the sparsity reached 90%. The interpolated sinogram by the DL neural network was fed to FBP algorithm for reconstruction. The result shows that both RMSE and SSIM of CT image are greatly improved. The experimental results demonstrate that this sinogram interpolation method produce significantly better results over standard linear interpolation methods when the sinogram data are extremely sparse.

Abstract--For homeland and transportation security applications, 2D X-ray explosive detection system (EDS) have been widely used, but they have limitations in recognizing 3D shape of the hidden objects. Among various types of 3D computed tomography (CT) systems to address this issue, this paper is interested in a stationary CT using fixed X-ray sources and detectors. However, due to the limited number of projection views, analytic reconstruction algorithms produce severe streaking artifacts. Inspired by recent success of deep learning approach for sparse view CT reconstruction, here we propose a novel image and sinogram domain deep learning architecture for 3D reconstruction from very sparse view measurement. The algorithm has been tested with the real data from a prototype 9-view dual energy stationary CT EDS carry-on baggage scanner developed by GEMSS Medical Systems, Korea, which confirms the superior reconstruction performance over the existing approaches.