Phonotrauma refers to vocal fold tissue damage resulting from exposure to forces during voicing. It occurs on a continuum from mild to severe, and treatment options can vary based on severity. Assessment of severity involves a clinician's expert judgment, which is costly and can vary widely in reliability. In this work, we present the first method for automatically classifying phonotrauma severity from vocal fold images. To account for the ordinal nature of the labels, we adopt a widely used ordinal regression framework. To account for label uncertainty, we propose a novel modification to ordinal regression loss functions that enables them to operate on soft labels reflecting annotator rating distributions. Our proposed soft ordinal regression method achieves predictive performance approaching that of clinical experts, while producing well-calibrated uncertainty estimates. By providing an automated tool for phonotrauma severity assessment, our work can enable large-scale studies of phonotrauma, ultimately leading to improved clinical understanding and patient care.

Severity assessment of Parkinson's disease (PD) using wearable sensors offers an effective, objective basis for clinical management. However, general-purpose time series models often lack pathological specificity in feature extraction, making it difficult to capture subtle signals highly correlated with PD.Furthermore, the temporal sparsity of PD symptoms causes key diagnostic features to be easily "diluted" by traditional aggregation methods, further complicating assessment. To address these issues, we propose the Multi-scale Frequency-Aware Adversarial Multi-Instance Network (MFAM). This model enhances feature specificity through a frequency decomposition module guided by medical prior knowledge. Furthermore, by introducing an attention-based multi-instance learning (MIL) framework, the model can adaptively focus on the most diagnostically valuable sparse segments.We comprehensively validated MFAM on both the public PADS dataset for PD versus differential diagnosis (DD) binary classification and a private dataset for four-class severity assessment. Experimental results demonstrate that MFAM outperforms general-purpose time series models in handling complex clinical time series with specificity, providing a promising solution for automated assessment of PD severity.

Traditional disaster analysis and modelling tools for assessing the severity of a disaster are predictive in nature. Based on the past observational data, these tools prescribe how the current input state (e.g., environmental conditions, situation reports) results in a severity assessment. However, these systems are not meant to be interventional in the causal sense, where the user can modify the current input state to simulate counterfactual "what-if" scenarios. In this work, we provide an alternative interventional tool that complements traditional disaster modelling tools by leveraging real-time data sources like satellite imagery, news, and social media. Our tool also helps understand the causal attribution of different factors on the estimated severity, over any given region of interest. In addition, we provide actionable recourses that would enable easier mitigation planning. Our source code is publicly available.

Stuttering is a complex disorder that requires specialized expertise for effective assessment and treatment. This paper presents an effort to enhance the FluencyBank dataset with a new stuttering annotation scheme based on established clinical standards. To achieve high-quality annotations, we hired expert clinicians to label the data, ensuring that the resulting annotations mirror real-world clinical expertise. The annotations are multi-modal, incorporating audiovisual features for the detection and classification of stuttering moments, secondary behaviors, and tension scores. In addition to individual annotations, we additionally provide a test set with highly reliable annotations based on expert consensus for assessing individual annotators and machine learning models. Our experiments and analysis illustrate the complexity of this task that necessitates extensive clinical expertise for valid training and evaluation of stuttering assessment models.

Chronic obstructive pulmonary disease (COPD) is a major global health concern, with accurate severity assessment crucial for effective management, especially in intensive care units (ICUs). This study presents a novel approach to COPD sever - ity classification using machine learning algorithms applied to the MIMIC - III dataset. Our work presents a new application of the MIMIC - III dataset and con - tributes to the growing field of artificial intelligence in critical care medicine. We developed a model to classify COPD severity based on available ICU parameters, including blood gas measurements and vital signs. Our methodology incorpo - rated semi - supervised learning techniques to leverage unlabeled data, enhancing model robustness. A random forest classifier demonstrated superior performance, achieving 92.51% accuracy and 0.98 ROC AUC distinguishing between mild - to - moderate and severe COPD cases. This approach offers a practical, accurate, and accessible tool for rapid COPD severity assessment in ICU settings, poten - tially improving clinical decision - making and patient outcomes. Future research should focus on external validation and integration into clinical decision support systems to enhance COPD management in the ICUs.

Depression is one of the leading causes of disability worldwide, posing a severe burden on individuals, healthcare systems, and society at large. Recent advancements in Large Language Models (LLMs) have shown promise in addressing mental health challenges, including the detection of depression through text-based analysis. However, current LLM-based methods often struggle with nuanced symptom identification and lack a transparent, step-by-step reasoning process, making it difficult to accurately classify and explain mental health conditions. To address these challenges, we propose a Chain-of-Thought Prompting approach that enhances both the performance and interpretability of LLM-based depression detection. Our method breaks down the detection process into four stages: (1) sentiment analysis, (2) binary depression classification, (3) identification of underlying causes, and (4) assessment of severity. By guiding the model through these structured reasoning steps, we improve interpretability and reduce the risk of overlooking subtle clinical indicators. We validate our method on the E-DAIC dataset, where we test multiple state-of-the-art large language models. Experimental results indicate that our Chain-of-Thought Prompting technique yields superior performance in both classification accuracy and the granularity of diagnostic insights, compared to baseline approaches.

Automatic detection and severity assessment of dysarthria are crucial for delivering targeted therapeutic interventions to patients. While most existing research focuses primarily on speech modality, this study introduces a novel approach that leverages both speech and text modalities. By employing cross-attention mechanism, our method learns the acoustic and linguistic similarities between speech and text representations. This approach assesses specifically the pronunciation deviations across different severity levels, thereby enhancing the accuracy of dysarthric detection and severity assessment. All the experiments have been performed using UA-Speech dysarthric database. Improved accuracies of 99.53% and 93.20% in detection, and 98.12% and 51.97% for severity assessment have been achieved when speaker-dependent and speaker-independent, unseen and seen words settings are used. These findings suggest that by integrating text information, which provides a reference linguistic knowledge, a more robust framework has been developed for dysarthric detection and assessment, thereby potentially leading to more effective diagnoses.

With the advancement of chatbots and the growing demand for automatic depression detection, identifying depression in patient conversations has gained more attention. However, prior methods often assess depression in a binary way or only a single score without diverse feedback and lack focus on enhancing dialogue responses. In this paper, we present a novel task of multi-aspect depression severity assessment via an inductive dialogue system (MaDSA), evaluating a patient's depression level on multiple criteria by incorporating an assessment-aided response generation. Further, we propose a foundational system for MaDSA, which induces psychological dialogue responses with an auxiliary emotion classification task within a hierarchical severity assessment structure. We synthesize the conversational dataset annotated with eight aspects of depression severity alongside emotion labels, proven robust via human evaluations. Experimental results show potential for our preliminary work on MaDSA.

Purpose: Artificial intelligence (AI) techniques have been extensively utilized for diagnosing and prognosis of several diseases in recent years. This study identifies, appraises and synthesizes published studies on the use of AI for the prognosis of COVID-19. Method: Electronic search was performed using Medline, Google Scholar, Scopus, Embase, Cochrane and ProQuest. Studies that examined machine learning or deep learning methods to determine the prognosis of COVID-19 using CT or chest X-ray images were included. Polled sensitivity, specificity area under the curve and diagnostic odds ratio were calculated. Result: A total of 36 articles were included; various prognosis-related issues, including disease severity, mechanical ventilation or admission to the intensive care unit and mortality, were investigated. Several AI models and architectures were employed, such as the Siamense model, support vector machine, Random Forest , eXtreme Gradient Boosting, and convolutional neural networks. The models achieved 71%, 88% and 67% sensitivity for mortality, severity assessment and need for ventilation, respectively. The specificity of 69%, 89% and 89% were reported for the aforementioned variables. Conclusion: Based on the included articles, machine learning and deep learning methods used for the prognosis of COVID-19 patients using radiomic features from CT or CXR images can help clinicians manage patients and allocate resources more effectively. These studies also demonstrate that combining patient demographic, clinical data, laboratory tests and radiomic features improves model performances.

In the fight against the COVID-19 pandemic, leveraging artificial intelligence to predict disease outcomes from chest radiographic images represents a significant scientific aim. The challenge, however, lies in the scarcity of large, labeled datasets with compatible tasks for training deep learning models without leading to overfitting. Addressing this issue, we introduce a novel multi-dataset multi-task training framework that predicts COVID-19 prognostic outcomes from chest X-rays (CXR) by integrating correlated datasets from disparate sources, distant from conventional multi-task learning approaches, which rely on datasets with multiple and correlated labeling schemes. Our framework hypothesizes that assessing severity scores enhances the model's ability to classify prognostic severity groups, thereby improving its robustness and predictive power. The proposed architecture comprises a deep convolutional network that receives inputs from two publicly available CXR datasets, AIforCOVID for severity prognostic prediction and BRIXIA for severity score assessment, and branches into task-specific fully connected output networks. Moreover, we propose a multi-task loss function, incorporating an indicator function, to exploit multi-dataset integration. The effectiveness and robustness of the proposed approach are demonstrated through significant performance improvements in prognosis classification tasks across 18 different convolutional neural network backbones in different evaluation strategies. This improvement is evident over single-task baselines and standard transfer learning strategies, supported by extensive statistical analysis, showing great application potential.