Link prediction in biomedical knowledge graphs (KGs) aims at predicting unknown interactions between entities, including drug-target interaction (DTI) and drug-drug interaction (DDI), which is critical for drug discovery and therapeutics. Previous methods prefer to utilize the rich semantic relations and topological structure of the KG to predict missing links, yielding promising outcomes. However, all these works only focus on improving the predictive performance without considering the inevitable noise and unreliable interactions existing in the KGs, which limits the development of KG-based computational methods. To address these limitations, we propose a Denoised Link Prediction framework, called DenoisedLP. DenoisedLP obtains reliable interactions based on the local subgraph by denoising noisy links in a learnable way, providing a universal module for mining underlying task-relevant relations. To collaborate with the smoothed semantic information, DenoisedLP introduces the semantic subgraph by blurring conflict relations around the predicted link. By maximizing the mutual information between the reliable structure and smoothed semantic relations, DenoisedLP emphasizes the informative interactions for predicting relation-specific links. Experimental results on real-world datasets demonstrate that DenoisedLP outperforms state-of-the-art methods on DTI and DDI prediction tasks, and verify the effectiveness and robustness of denoising unreliable interactions on the contaminated KGs.

Most existing ontology matching methods utilize the literal information to discover alignments. However, some literal information in ontologies may be opaque and some ontologies may not have sufficient literal information. In this paper, these ontologies are named as weak informative ontologies (WIOs) and it is challenging for existing methods to matching WIOs. On one hand, string-based and linguistic-based matching methods cannot work well for WIOs. On the other hand, some matching methods use external resources to improve their performance, but collecting and processing external resources is still time-consuming. To address this issue, this paper proposes a practical method for matching WIOs by employing the ontology structure information to discover alignments. First, the semantic subgraphs are extracted from the ontology graph to capture the precise meanings of ontology elements. Then, a new similarity propagation model is designed for matching WIOs. Meanwhile, in order to avoid meaningless propagation, the similarity propagation is constrained by semantic subgraphs and other conditions. Consequently, the similarity propagation model ensures a balance between efficiency and quality during matching. Finally, the similarity propagation model uses a few credible alignments as seeds to find more alignments, and some useful strategies are adopted to improve the performance. This matching method for WIOs has been implemented in the ontology matching system Lily. Experimental results on public OAEI benchmark datasets demonstrate that Lily significantly outperforms most of the state-of-the-art works in both WIO matching tasks and general ontology matching tasks. In particular, Lily increases the recall by a large margin, while it still obtains high precision of matching results.

Traditional Graph Neural Network (GNN), as a graph representation learning method, is constrained by label information. However, Graph Contrastive Learning (GCL) methods, which tackle the label problem effectively, mainly focus on the feature information of the global graph or small subgraph structure (e.g., the first-order neighborhood). In the paper, we propose a Local Structure-aware Graph Contrastive representation Learning method (LS-GCL) to model the structural information of nodes from multiple views. Specifically, we construct the semantic subgraphs that are not limited to the first-order neighbors. For the local view, the semantic subgraph of each target node is input into a shared GNN encoder to obtain the target node embeddings at the subgraph-level. Then, we use a pooling function to generate the subgraph-level graph embeddings. For the global view, considering the original graph preserves indispensable semantic information of nodes, we leverage the shared GNN encoder to learn the target node embeddings at the global graph-level. The proposed LS-GCL model is optimized to maximize the common information among similar instances at three various perspectives through a multi-level contrastive loss function. Experimental results on five datasets illustrate that our method outperforms state-of-the-art graph representation learning approaches for both node classification and link prediction tasks.