Discovering the neural mechanisms underpinning cognition is one of the grand challenges of neuroscience. However, previous approaches for building models of RNN dynamics that explain behaviour required iterative refinement of architectures and/or optimisation objectives, resulting in a piecemeal, and mostly heuristic, human-in-the-loop process. Here, we offer an alternative approach that automates the discovery of viable RNN mechanisms by explicitly training RNNs to reproduce behaviour, including the same characteristic errors and suboptimalities, that humans and animals produce in a cognitive task. Achieving this required two main innovations. First, as the amount of behavioural data that can be collected in experiments is often too limited to train RNNs, we use a non-parametric generative model of behavioural responses to produce surrogate data for training RNNs. Second, to capture all relevant statistical aspects of the data, we developed a novel diffusion model-based approach for training RNNs. To showcase the potential of our approach, we chose a visual working memory task as our test-bed, as behaviour in this task is well known to produce response distributions that are patently multimodal (due to swap errors). The resulting network dynamics correctly qualitative features of macaque neural data. Importantly, these results were not possible to obtain with more traditional approaches, i.e., when only a limited set of behavioural signatures (rather than the full richness of behavioural response distributions) were fitted, or when RNNs were trained for task optimality (instead of reproducing behaviour). Our approach also yields novel predictions about the mechanism of swap errors, which can be readily tested in experiments. These results suggest that fitting RNNs to rich patterns of behaviour provides a powerful way to automatically discover mechanisms of important cognitive functions.

The use of Large Language Models (LLMs) for simulating human perspectives via persona prompting is gaining traction in computational social science. However, well-curated, empirically grounded persona collections remain scarce, limiting the accuracy and representativeness of such simulations. Here we introduce the German General Personas (GGP) collection, a comprehensive and representative persona prompt collection built from the German General Social Survey (ALLBUS). The GGP and its persona prompts are designed to be easily plugged into prompts for all types of LLMs and tasks, steering models to generate responses aligned with the underlying German population. We evaluate GGP by prompting various LLMs to simulate survey response distributions across diverse topics, demonstrating that GGP-guided LLMs outperform state-of-the-art classifiers, particularly under data scarcity. Furthermore, we analyze how the representativity and attribute selection within persona prompts affect alignment with population responses. Our findings suggest that GGP provides a potentially valuable resource for research on LLM-based social simulations that enables more systematic explorations of population-aligned persona prompting in NLP and social science research.

As Large Language Models (LLMs) increasingly influence high-stakes decision-making across global contexts, ensuring their alignment with diverse cultural values has become a critical governance challenge. This study presents a Multi-Layered Auditing Platform for Responsible AI that systematically evaluates cross-cultural value alignment in China-origin and Western-origin LLMs through four integrated methodologies: Ethical Dilemma Corpus for assessing temporal stability, Diversity-Enhanced Framework (DEF) for quantifying cultural fidelity, First-Token Probability Alignment for distributional accuracy, and Multi-stAge Reasoning frameworK (MARK) for interpretable decision-making. Our comparative analysis of 20+ leading models, such as Qwen, GPT-4o, Claude, LLaMA, and DeepSeek, reveals universal challenges-fundamental instability in value systems, systematic under-representation of younger demographics, and non-linear relationships between model scale and alignment quality-alongside divergent regional development trajectories. While China-origin models increasingly emphasize multilingual data integration for context-specific optimization, Western models demonstrate greater architectural experimentation but persistent U.S.-centric biases. Neither paradigm achieves robust cross-cultural generalization. We establish that Mistral-series architectures significantly outperform LLaMA3-series in cross-cultural alignment, and that Full-Parameter Fine-Tuning on diverse datasets surpasses Reinforcement Learning from Human Feedback in preserving cultural variation...

Neural circuits are typically comprised of populations of primary (excitatory) neurons and local (inhibitory) interneurons.

Existing works have already proposed various inductive biases from diverse perspectives.

A variety of forces shape neural representations in the brain.

Characterizing the activity of sensory neurons is a major goal of neural system identification.

Dale's principle implies that biological neural networks are composed of neurons

Large language models (LLMs) offer a powerful opportunity to simulate the results of social science experiments. In this work, we demonstrate that finetuning LLMs directly on individual-level responses from past experiments meaningfully improves the accuracy of such simulations across diverse social science domains. We construct SocSci210 via an automatic pipeline, a dataset comprising 2.9 million responses from 400,491 participants in 210 open-source social science experiments. Through finetuning, we achieve multiple levels of generalization. In completely unseen studies, our strongest model, Socrates-Qwen-14B, produces predictions that are 26% more aligned with distributions of human responses to diverse outcome questions under varying conditions relative to its base model (Qwen2.5-14B), outperforming GPT-4o by 13%. By finetuning on a subset of conditions in a study, generalization to new unseen conditions is particularly robust, improving by 71%. Since SocSci210 contains rich demographic information, we reduce demographic parity difference, a measure of bias, by 10.6% through finetuning. Because social sciences routinely generate rich, topic-specific datasets, our findings indicate that finetuning on such data could enable more accurate simulations for experimental hypothesis screening. We release our data, models and finetuning code at stanfordhci.github.io/socrates.