In most neurophysiology laboratories this classification task is simplified by limiting investigations to single, electrically well-isolated neurons recorded one at a time. However, for those interested in sampling the activities of many single neurons simultaneously, waveform classification becomes a serious concern. In this paper we describe and constrast three approaches to this problem each designed not only to recognize isolated neural events, but also to separately classify temporally overlapping events in real time. These two formulations are then compared to a simple template matching implementation. Analysis with real neural signals reveals that simple template matching is a better solution to this problem than either neural network approach.

Ion channels are the dynamical systems of the nervous system. Their distribution within the membrane governs not only communication of in(cid:173) formation between neurons, but also how that information is integrated within the cell. Here, an argument is presented for an'anti-Hebbian' rule for changing the distribution of voltage-dependent ion channels in order to flatten voltage curvatures in dendrites. Simulations show that this rule can account for the self-organisation of dynamical receptive field properties such as resonance and direction selectivity. It also creates the conditions for the faithful conduction within the cell of signals to which the cell has been exposed.

Behold this dazzling dance between machine and biology, for this is how neural networks could express the sheer joy of being alive.

In 1739, Parisians flocked to see an exhibition of automata by the French inventor Jacques de Vaucanson performing feats assumed impossible by machines. In addition to human-like flute and drum players, the collection contained a golden duck, standing on a pedestal, quacking and defecating. It was, in fact, a digesting duck. When offered pellets by the exhibitor, it would pick them out of his hand and consume them with a gulp. Vaucanson died in 1782 with his reputation as a trailblazer in artificial digestion intact.

In 1739, Parisians flocked to see an exhibition of automata by the French inventor Jacques de Vaucanson performing feats assumed impossible by machines. In addition to human-like flute and drum players, the collection contained a golden duck, standing on a pedestal, quacking and defecating. It was, in fact, a digesting duck. When offered pellets by the exhibitor, it would pick them out of his hand and consume them with a gulp. Vaucanson died in 1782 with his reputation as a trailblazer in artificial digestion intact.

In 1739, Parisians flocked to see an exhibition of automata by the French inventor Jacques de Vaucanson performing feats assumed impossible by machines. In addition to human-like flute and drum players, the collection contained a golden duck, standing on a pedestal, quacking and defecating. It was, in fact, a digesting duck. When offered pellets by the exhibitor, it would pick them out of his hand and consume them with a gulp. Vaucanson died in 1782 with his reputation as a trailblazer in artificial digestion intact.

Integrate-and-Fire-type models are usually criticized because of their simplicity. On the other hand, the Integrate-and-Fire model is the basis of most of the theoretical studies on spiking neuron models. Here, we develop a sequential procedure to quantitatively evaluate an equivalent Integrate-and-Fire-type model based on intracellular recordings of cortical pyramidal neurons. We find that the resulting effective model is sufficient to predict the spike train of the real pyramidal neuron with high accuracy. In in vivo-like regimes, predicted and recorded traces are almost indistinguishable and a significant part of the spikes can be predicted at the correct timing. Slow processes like spike-frequency adaptation are shown to be a key feature in this context since they are necessary for the model to connect between different driving regimes.

Integrate-and-Fire-type models are usually criticized because of their simplicity. On the other hand, the Integrate-and-Fire model is the basis of most of the theoretical studies on spiking neuron models. Here, we develop a sequential procedure to quantitatively evaluate an equivalent Integrate-and-Fire-type model based on intracellular recordings of cortical pyramidal neurons. We find that the resulting effective model is sufficient to predict the spike train of the real pyramidal neuron with high accuracy. In in vivo-like regimes, predicted and recorded traces are almost indistinguishable and a significant part of the spikes can be predicted at the correct timing. Slow processes like spike-frequency adaptation are shown to be a key feature in this context since they are necessary for the model to connect between different driving regimes.

Integrate-and-Fire-type models are usually criticized because of their simplicity. On the other hand, the Integrate-and-Fire model is the basis ofmost of the theoretical studies on spiking neuron models. Here, we develop a sequential procedure to quantitatively evaluate an equivalent Integrate-and-Fire-typemodel based on intracellular recordings of cortical pyramidal neurons. We find that the resulting effective model is sufficient to predict the spike train of the real pyramidal neuron with high accuracy. In in vivo-like regimes, predicted and recorded traces are almost indistinguishable and a significant part of the spikes can be predicted atthe correct timing. Slow processes like spike-frequency adaptation are shown to be a key feature in this context since they are necessary for the model to connect between different driving regimes.

Recent experiments show that the neural codes at work in a wide range of creatures share some common features. At first sight, these observations seem unrelated. However, we show that these features arise naturally in a linear filtered threshold crossing (LFTC) model when we set the threshold to maximize the transmitted information. This maximization process requires neural adaptation to not only the DC signal level, as in conventional light and dark adaptation, but also to the statistical structure of the signal and noise distributions. We also present a new approach for calculating the mutual information between a neuron's output spike train and any aspect of its input signal which does not require reconstruction of the input signal. This formulation is valid provided the correlations in the spike train are small, and we provide a procedure for checking this assumption. This paper is based on joint work (DeWeese [1], 1995). Preliminary results from the LFTC model appeared in a previous proceedings (DeWeese [2], 1995), and the conclusions we reached at that time have been reaffirmed by further analysis of the model.