Digital Health Technologies (DHTs) including consumer wearable devices and digital health applications offer an opportunity for continuous, large-scale data collection. Wearables give insight into physiological biomarkers that help us understand the human body, through passive data collection. Such data can be collected at a regularity that would be impossible otherwise. Digital health applications provide the chance to collect diverse types of data from clinically validated surveys, GPS, and contextual inputs. This combination has the ability to make profound advances in our understanding of the factors that affect individuals on a personal and population level [Grace et al., 2025]. One of these factors is the menstrual cycle. Particularly because of its inter-individual variability, studying it requires large sample sizes, and to truly grasp its effects on the human body, it needs to be observed on a near-daily scale [Bull et al., 2019].

Embedded Sensing Group ESG Institute of Computer Science in V orarlberg ICV, University of St. Gallen HSG, Switzerland E-mail: leonardo.rossi@student.unisg.ch, Abstract--Triathlon training, which involves high-volume swimming, cycling, and running, places athletes at substantial risk for overuse injuries due to repetitive physiological stress. Current injury prediction approaches primarily rely on training load metrics, often neglecting critical factors such as sleep quality, stress, and individual lifestyle patterns that significantly influence recovery and injury susceptibility. We introduce a novel synthetic data generation framework tailored explicitly for triathlon. This framework generates physiologically plausible athlete profiles, simulates individualized training programs that incorporate periodization and load-management principles, and integrates daily-life factors such as sleep quality, stress levels, and recovery states. We evaluated machine learning models (LASSO, Random Forest, and XGBoost) showing high predictive performance (AUC up to 0.86), identifying sleep disturbances, heart rate variability, and stress as critical early indicators of injury risk. This wearable-driven approach not only enhances injury prediction accuracy but also provides a practical solution to overcoming real-world data limitations, offering a pathway toward a holistic, context-aware athlete monitoring. Triathlon is a demanding multi-sport discipline that combines swimming, cycling, and running.

Monitoring and analyzing electrocardiogram (ECG) signals, even under varying physiological conditions, including those influenced by physical activity, drugs and stress, is crucial to accurately assess cardiac health. However, current AI-based methods often fail to account for how these factors interact and alter ECG patterns, ultimately limiting their applicability in real-world settings. This study introduces IKrNet, a novel neural network model, which identifies drug-specific patterns in ECGs amidst certain physiological conditions. IKrNet's architecture incorporates spatial and temporal dynamics by using a convolutional backbone with varying receptive field size to capture spatial features. A bi-directional Long Short-Term Memory module is also employed to model temporal dependencies. By treating heart rate variability as a surrogate for physiological fluctuations, we evaluated IKrNet's performance across diverse scenarios, including conditions with physical stress, drug intake alone, and a baseline without drug presence. Our assessment follows a clinical protocol in which 990 healthy volunteers were administered 80mg of Sotalol, a drug which is known to be a precursor to Torsades-de-Pointes, a life-threatening arrhythmia. We show that IKrNet outperforms state-of-the-art models' accuracy and stability in varying physiological conditions, underscoring its clinical viability.

-- Depression is a complex mental disorder characterized by a diverse range of observable and measurable indicators that go beyond traditional subjective assessments. Recent research has increasingly focused on objective, passive, and continuous monitoring using wearable devices to gain more precise insights into the physiological and behavioral aspects of depression. However, most existing studies primarily distinguish between healthy and depressed individuals, adopting a binary classification that fails to capture the heterogeneity of depressive disorders. In this study, we leverage wearable devices to predict depression subtypes--specifically unipolar and bipolar depression--aiming to identify distinctive biomarkers that could enhance diagnostic precision and support personalized treatment strategies. T o this end, we introduce the CAL YPSO dataset, designed for non-invasive detection of depression subtypes and symptomatology through physiological and behavioral signals, including blood volume pulse, electro-dermal activity, body temperature, and three-axis acceleration. Additionally, we establish a benchmark on the dataset using well-known features and standard machine learning methods. Preliminary results indicate that features related to physical activity, extracted from accelerometer data, are the most effective in distinguishing between unipolar and bipolar depression, achieving an accuracy of 96.77%. T emperature-based features also showed high discriminative power, reaching an accuracy of 93.55%. I. INTRODUCTION Depression is a common psychiatric disorders affecting approximately 280 million people worldwide, accounting for 3.8% of the global population.

Alterations in Heart Rate (HR) and Heart Rate Variability (HRV) can reflect autonomic dysfunction associated with neurodegeneration. We investigate the influence of Mild Cognitive Impairment (MCI) on HR and its variability measures in the Indian population by designing a complete signal processing pipeline to detect the R-wave peaks and compute HR and HRV features from ECG recordings of 10 seconds, for point-of-care applications. The study cohort involves 297 urban participants, among which 48.48% are male and 51.51% are female. From the Addenbrooke's Cognitive Examination-III (ACE-III), MCI is detected in 19.19% of participants and the rest, 80.8% of them are cognitively healthy. Statistical features like central tendency (mean and root mean square (RMS) of the Normal-to-Normal (NN) intervals) and dispersion (standard deviation (SD) of all NN intervals (SDNN) and root mean square of successive differences of NN intervals (RMSSD)) of beat-to-beat intervals are computed. The Wilcoxon rank sum test reveals that mean of NN intervals (p = 0.0021), the RMS of NN intervals (p = 0.0014), the SDNN (p = 0.0192) and the RMSSD (p = 0.0206) values differ significantly between MCI and non-MCI classes, for a level of significance, 0.05. Machine learning classifiers like, Support Vector Machine (SVM), Discriminant Analysis (DA) and Naive Bayes (NB) driven by mean NN intervals, RMS, SDNN and RMSSD, show a high accuracy of 80.80% on each individual feature input. Individuals with MCI are observed to have comparatively higher HR than healthy subjects. HR and its variability can be considered as potential biomarkers for detecting MCI.

The early and accurate diagnosis of sepsis is critical for enhancing patient outcomes. This study aims to use heart rate variability (HRV) features to develop an effective predictive model for sepsis detection. Critical HRV features are identified through feature engineering methods, including statistical bootstrapping and the Boruta algorithm, after which XGBoost and Random Forest classifiers are trained with differential hyperparameter settings. In addition, ensemble models are constructed to pool the prediction probabilities of high-recall and high-precision classifiers and improve model performance. Finally, a neural network model is trained on the HRV features, achieving an F1 score of 0.805, a precision of 0.851, and a recall of 0.763. The best-performing machine learning model is compared to this neural network through an interpretability analysis, where Local Interpretable Model-agnostic Explanations are implemented to determine decision-making criterion based on numerical ranges and thresholds for specific features. This study not only highlights the efficacy of HRV in automated sepsis diagnosis but also increases the transparency of black box outputs, maximizing clinical applicability.

This study introduces a novel, rich dataset obtained from home sleep apnea tests using the FDA-approved WatchPAT-300 device, collected from 7,077 participants over 21,412 nights. The dataset comprises three levels of sleep data: raw multi-channel time-series from sensors, annotated sleep events, and computed summary statistics, which include 447 features related to sleep architecture, sleep apnea, and heart rate variability (HRV). We present reference values for Apnea/Hypopnea Index (AHI), sleep efficiency, Wake After Sleep Onset (WASO), and HRV sample entropy, stratified by age and sex. Moreover, we demonstrate that the dataset improves the predictive capability for various health related traits, including body composition, bone density, blood sugar levels and cardiovascular health. These results illustrate the dataset's potential to advance sleep research, personalized healthcare, and machine learning applications in biomedicine.

Tactile interaction plays a crucial role in interactions between people. Touch can, for example, help people calm down and lower physiological stress responses. Consequently, it is believed that tactile and haptic interaction matter also in human-robot interaction. We study if the intensity of the tactile interaction has an impact on people, and do so by studying whether different intensities of tactile interaction modulate physiological measures and task performance. We use a paradigm in which a small humanoid robot is used to encourage risk-taking behaviour, relying on peer encouragement to take more risks which might lead to a higher pay-off, but potentially also to higher losses. For this, the Balloon Analogue Risk Task (BART) is used as a proxy for the propensity to take risks. We study four conditions, one control condition in which the task is completed without a robot, and three experimental conditions in which a robot is present that encourages risk-taking behaviour with different degrees of tactile interaction. The results show that both low-intensity and high-intensity tactile interaction increase people's risk-taking behaviour. However, low-intensity tactile interaction increases comfort and lowers stress, whereas high-intensity touch does not.

Increased use of sensor signals from wearable devices as rich sources of physiological data has sparked growing interest in developing health monitoring systems to identify changes in an individual's health profile. Indeed, machine learning models for sensor signals have enabled a diverse range of healthcare related applications including early detection of abnormalities, fertility tracking, and adverse drug effect prediction. However, these models can fail to account for the dependent high-dimensional nature of the underlying sensor signals. In this paper, we introduce Latent Temporal Flows, a method for multivariate time-series modeling tailored to this setting. We assume that a set of sequences is generated from a multivariate probabilistic model of an unobserved time-varying low-dimensional latent vector. Latent Temporal Flows simultaneously recovers a transformation of the observed sequences into lower-dimensional latent representations via deep autoencoder mappings, and estimates a temporally-conditioned probabilistic model via normalizing flows. Using data from the Apple Heart and Movement Study (AH&MS), we illustrate promising forecasting performance on these challenging signals. Additionally, by analyzing two and three dimensional representations learned by our model, we show that we can identify participants' $\text{VO}_2\text{max}$, a main indicator and summary of cardio-respiratory fitness, using only lower-level signals. Finally, we show that the proposed method consistently outperforms the state-of-the-art in multi-step forecasting benchmarks (achieving at least a $10\%$ performance improvement) on several real-world datasets, while enjoying increased computational efficiency.

Heart rate variability is an indicator of heart health. Mohammad Moshawrab's research on this topic received the best paper award at the 19th International Conference on Mobile Systems and Persuasive Computing (MobiSPC), held August 9-11 in Niagara Falls, Canada. Like the other papers accepted by MobiSPC 2022, " Cardiovascular Events Prediction using Artificial Intelligence Models and Heart Rate Variability"is published by Elsevier Science in the online open access Procedia Computer Science series. Mohammad Moshawrab is a doctoral student in engineering at the Université du Québec à Rimouski (UQAR), which welcomes about 6,700 students each year, including nearly 600 international students from more than 45 countries. His doctorate in engineering aims to train specialists capable of designing and carrying out independently a research program to advance the state of knowledge in the engineering of physical systems and industrial processes.