In Romania, cardiovascular problems are the leading cause of death, accounting for nearly one-third of annual fatalities. The severity of this situation calls for innovative diagnosis method for cardiovascular diseases. This article aims to explore efficient, light-weight and rapid methods for arrhythmia diagnosis, in resource-constrained healthcare settings. Due to the lack of Romanian public medical data, we trained our systems using international public datasets, having in mind that the ECG signals are the same regardless the patients' nationality. Within this purpose, we combined multiple datasets, usually used in the field of arrhythmias classification: PTB-XL electrocardiography dataset , PTB Diagnostic ECG Database, China 12-Lead ECG Challenge Database, Georgia 12-Lead ECG Challenge Database, and St. Petersburg INCART 12-lead Arrhythmia Database. For the input data, we employed ECG signal processing methods, specifically a variant of the Pan-Tompkins algorithm, useful in arrhythmia classification because it provides a robust and efficient method for detecting QRS complexes in ECG signals. Additionally, we used machine learning techniques, widely used for the task of classification, including convolutional neural networks (1D CNNs, 2D CNNs, ResNet) and Vision Transformers (ViTs). The systems were evaluated in terms of accuracy and F1 score. We annalysed our dataset from two perspectives. First, we fed the systems with the ECG signals and the GRU-based 1D CNN model achieved the highest accuracy of 93.4% among all the tested architectures. Secondly, we transformed ECG signals into images and the CNN2D model achieved an accuracy of 92.16%.

The classification of time series data is a well-studied problem with numerous practical applications, such as medical diagnosis and speech recognition. A popular and effective approach is to classify new time series in the same way as their nearest neighbours, whereby proximity is defined using Dynamic Time Warping (DTW) distance, a measure analogous to sequence alignment in bioinformatics. However, practitioners are not only interested in accurate classification, they are also interested in why a time series is classified a certain way. To this end, we introduce here the problem of finding a minimum length subsequence of a time series, the removal of which changes the outcome of the classification under the nearest neighbour algorithm with DTW distance. Informally, such a subsequence is expected to be relevant for the classification and can be helpful for practitioners in interpreting the outcome. We describe a simple but optimized implementation for detecting these subsequences and define an accompanying measure to quantify the relevance of every time point in the time series for the classification. In tests on electrocardiogram data we show that the algorithm allows discovery of important subsequences and can be helpful in detecting abnormalities in cardiac rhythms distinguishing sick from healthy patients.

Objective: This work aims at providing a new method for the automatic detection of atrial fibrillation, other arrhythmia and noise on short single lead ECG signals, emphasizing the importance of the interpretability of the classification results. Approach: A morphological and rhythm description of the cardiac behavior is obtained by a knowledge-based interpretation of the signal using the \textit{Construe} abductive framework. Then, a set of meaningful features are extracted for each individual heartbeat and as a summary of the full record. The feature distributions were used to elucidate the expert criteria underlying the labeling of the 2017 Physionet/CinC Challenge dataset, enabling a manual partial relabeling to improve the consistency of the classification rules. Finally, state-of-the-art machine learning methods are combined to provide an answer on the basis of the feature values. Main results: The proposal tied for the first place in the official stage of the Challenge, with a combined $F_1$ score of 0.83, and was even improved in the follow-up stage to 0.85 with a significant simplification of the model. Significance: This approach demonstrates the potential of \textit{Construe} to provide robust and valuable descriptions of temporal data even with significant amounts of noise and artifacts. Also, we discuss the importance of a consistent classification criteria in manually labeled training datasets, and the fundamental advantages of knowledge-based approaches to formalize and validate that criteria.

In this work, we propose an abductive framework for biosignal interpretation, based on the concept of Temporal Abstraction Patterns. A temporal abstraction pattern defines an abstraction relation between an observation hypothesis and a set of observations constituting its evidence support. New observations are generated abductively from any subset of the evidence of a pattern, building an abstraction hierarchy of observations in which higher levels contain those observations with greater interpretative value of the physiological processes underlying a given signal. Non-monotonic reasoning techniques have been applied to this model in order to find the best interpretation of a set of initial observations, permitting even to correct these observations by removing, adding or modifying them in order to make them consistent with the available domain knowledge. Some preliminary experiments have been conducted to apply this framework to a well known and bounded problem: the QRS detection on ECG signals. The objective is not to provide a new better QRS detector, but to test the validity of an abductive paradigm. These experiments show that a knowledge base comprising just a few very simple rhythm abstraction patterns can enhance the results of a state of the art algorithm by significantly improving its detection F1-score, besides proving the ability of the abductive framework to correct both sensitivity and specificity failures.

Realizations of stochastic process are often observed temporal data or functional data. There are growing interests in classification of dynamic or functional data. The basic feature of functional data is that the functional data have infinite dimensions and are highly correlated. An essential issue for classifying dynamic and functional data is how to effectively reduce their dimension and explore dynamic feature. However, few statistical methods for dynamic data classification have directly used rich dynamic features of the data. We propose to use second order ordinary differential equation (ODE) to model dynamic process and principal differential analysis to estimate constant or time-varying parameters in the ODE. We examine differential dynamic properties of the dynamic system across different conditions including stability and transient-response, which determine how the dynamic systems maintain their functions and performance under a broad range of random internal and external perturbations. We use the parameters in the ODE as features for classifiers. As a proof of principle, the proposed methods are applied to classifying normal and abnormal QRS complexes in the electrocardiogram (ECG) data analysis, which is of great clinical values in diagnosis of cardiovascular diseases. We show that the ODE-based classification methods in QRS complex classification outperform the currently widely used neural networks with Fourier expansion coefficients of the functional data as their features. We expect that the dynamic model-based classification methods may open a new avenue for functional data classification.

We examine the performance of Total Variation (TV) smoothing for processing of noisy Electrocardiogram (ECG) recorded by an ambulatory device. The TV smoothing is compared with traditionally-used band-pass filtering using ECG with artificially added noise, as well as with real-world noise obtained during physiological monitoring. The fundamental difference between TV smoothing and traditional band-pass filtering is that TV smoothing allow preserving sharp slopes in the ECG, while traditional smoothing dampens them. Since the QRS complex represents a feature with steep slopes, the TV smoothing is a better choice ECG filtering. We found that TV smoothing outperforms traditional filtering on ECG signals recorded under different conditions and can be used as effective filtering tool in popular QRS detection algorithms.

We examine the use of hidden Markov and hidden semi-Markov models for automatically segmenting an electrocardiogram waveform into its constituent waveform features. An undecimated wavelet transform is used to generate an overcomplete representation of the signal that is more appropriate for subsequent modelling. We show that the state durations implicit in a standard hidden Markov model are ill-suited to those of real ECG features, and we investigate the use of hidden semi-Markov models for improved state duration modelling.

We examine the use of hidden Markov and hidden semi-Markov models for automatically segmenting an electrocardiogram waveform into its constituent waveform features. An undecimated wavelet transform is used to generate an overcomplete representation of the signal that is more appropriate for subsequent modelling. We show that the state durations implicit in a standard hidden Markov model are ill-suited to those of real ECG features, and we investigate the use of hidden semi-Markov models for improved state duration modelling.

We examine the use of hidden Markov and hidden semi-Markov models forautomatically segmenting an electrocardiogram waveform into its constituent waveform features. An undecimated wavelet transform is used to generate an overcomplete representation of the signal that is more appropriate for subsequent modelling. We show that the state durations implicitin a standard hidden Markov model are ill-suited to those of real ECG features, and we investigate the use of hidden semi-Markov models for improved state duration modelling.

An analogue VLSI neural network has been designed and tested to perform cardiac morphology classification tasks. Analogue techniques werechosen to meet the strict power and area requirements of an Implantable Cardioverter Defibrillator (ICD) system. The robustness ofthe neural network architecture reduces the impact of noise, drift and offsets inherent in analogue approaches. The network isa 10:6:3 multi-layer perceptron with on chip digital weight storage, a bucket brigade input to feed the Intracardiac Electrogram (ICEG)to the network and has a winner take all circuit at the output. The network was trained in loop and included a commercial ICD in the signal processing path. The system has successfully distinguishedarrhythmia for different patients with better than 90% true positive and true negative detections for dangerous rhythms which cannot be detected by present ICDs. The chip was implemented in 1.2um CMOS and consumes less than 200nW maximum averagepower in an area of 2.2 x 2.2mm2. 1 INTRODUCTION To the present time, most ICDs have used timing information from ventricular leads only to classify rhythms which has meant some dangerous rhythms can not be distinguished from safe ones, limiting the use of the device.