Methods: We developed a self-supervised deep learning model that extracts meaningful patterns from multi-modal signals (Electroencephalography (EEG), Electrocardiography (ECG), and respiratory signals). The model was trained on data from 4,398 participants. Projection scores were derived by contrasting embeddings from individuals with and without CVD outcomes. External validation was conducted in an independent cohort with 1,093 participants. The source code is available on https://github.com/miraclehetech/sleep-ssl. Results: The projection scores revealed distinct and clinically meaningful patterns across modalities. ECG-derived features were predictive of both prevalent and incident cardiac conditions, particularly CVD mortality. EEG-derived features were predictive of incident hypertension and CVD mortality. Respiratory signals added complementary predictive value. Combining these projection scores with the Framingham Risk Score consistently improved predictive performance, achieving area under the curve values ranging from 0.607 to 0.965 across different outcomes. Findings were robustly replicated and validated in the external testing cohort. Conclusion: Our findings demonstrate that the proposed framework can generate individualized CVD risk scores directly from PSG data. The resulting projection scores have the potential to be integrated into clinical practice, enhancing risk assessment and supporting personalized care.

We consider the problem of segmenting a large population of customers into non-overlapping groups with similar preferences, using diverse preference observations such as purchases, ratings, clicks, etc. over subsets of items. We focus on the setting where the universe of items is large (ranging from thousands to millions) and unstructured (lacking well-defined attributes) and each customer provides observations for only a few items. These data characteristics limit the applicability of existing techniques in marketing and machine learning. To overcome these limitations, we propose a model-based projection technique, which transforms the diverse set of observations into a more comparable scale and deals with missing data by projecting the transformed data onto a low-dimensional space. We then cluster the projected data to obtain the customer segments. Theoretically, we derive precise necessary and sufficient conditions that guarantee asymptotic recovery of the true customer segments. Empirically, we demonstrate the speed and performance of our method in two real-world case studies: (a) 84% improvement in the accuracy of new movie recommendations on the MovieLens data set and (b) 6% improvement in the performance of similar item recommendations algorithm on an offline dataset at eBay. We show that our method outperforms standard latent-class and demographic-based techniques.