Predicting an individual's aging trajectory is a central challenge in preventative medicine and bioinformatics. While machine learning models can predict chronological age from biomarkers, they often fail to capture the dynamic, longitudinal nature of the aging process. In this work, we developed and validated a machine learning pipeline to predict age using a longitudinal cohort with data from two distinct time periods (2019-2020 and 2021-2022). We demonstrate that a model using only static, cross-sectional biomarkers has limited predictive power when generalizing to future time points. However, by engineering novel features that explicitly capture the rate of change (slope) of key biomarkers over time, we significantly improved model performance. Our final LightGBM model, trained on the initial wave of data, successfully predicted age in the subsequent wave with high accuracy ($R^2 = 0.515$ for males, $R^2 = 0.498$ for females), significantly outperforming both traditional linear models and other tree-based ensembles. SHAP analysis of our successful model revealed that the engineered slope features were among the most important predictors, highlighting that an individual's health trajectory, not just their static health snapshot, is a key determinant of biological age. Our framework paves the way for clinical tools that dynamically track patient health trajectories, enabling early intervention and personalized prevention strategies for age-related diseases.

Fox News anchor Bret Baier has the latest on the Murdoch Children's Research Institute's partnership with the Gladstone Institutes for the'Decoding Broken Hearts' initiative on'Special Report.' A simple selfie could hold hidden clues to one's biological age -- and even how long they'll live. That's according to researchers from Mass General Brigham, who developed a deep-learning algorithm called FaceAge. Using a photo of someone's face, the artificial intelligence tool generates predictions of the subject's biological age, which is the rate at which they are aging as opposed to their chronological age. FaceAge also predicts survival outcomes for people with cancer, according to a press release from MGB.

Artificial intelligence (AI) can produce digital biomarkers of ageing and frailty by gathering physical activity data from smartphones and other wearables, scientists have found. The finding, published in the journal Scientific Reports, untaps the emerging potential of combining wearable sensors and AI technologies for continuous health risk monitoring with real-time feedback to life and health insurance, healthcare and wellness providers. "Artificial Intelligence is a powerful tool in pattern recognition and has demonstrated outstanding performance in visual object identification, speech recognition, and other fields," said Peter Fedichev from the Moscow Institute of Physics and Technology (MIPT) in Russia. "Recent promising examples in the field of medicine include neural networks showing cardiologist-level performance in detection of arrhythmia in ECG data, deriving biomarkers of age from clinical blood biochemistry, and predicting mortality based on electronic medical records," said Fedichev. The researches analysed physical activity records and clinical data from a large 2003-2006 US National Health and Nutrition Examination Survey (NHANES).

Researches at longevity biotech company GERO and Moscow Institute of Physics and Technology have developed a computer algorithm that uses Artificial Intelligence to predict biological age and the risk of mortality based on physical activity. The paper is published in Scientific Reports.

IMAGE: This is a screenshot of the Gero Lifespan app. Moscow, March 29, 2018 - Researchers from the longevity biotech company GERO and Moscow Institute of Physics and Technology (MIPT) have shown that physical activity data acquired from wearables can be used to produce digital biomarkers of aging and frailty. Many physiological parameters demonstrate tight correlations with age. Various biomarkers of age, such as DNA methylation, gene expression or circulating blood factor levels could be used to build accurate «biological clocks» to obtain individual biological age and the rate of aging estimations. Yet large-scale biochemical or genomic profiling is still logistically difficult and expensive for any practical applications beyond academic research.