Over half of cancer patients experience long-term pain management challenges.

Annotateddimensionsinclude Valence, Arousal and Emotion label, with annotations gathered using Prolific.

Modern industrial and service processes generate high-dimensional, non-Gaussian, and contamination-prone data that challenge the foundational assumptions of classical Statistical Process Control (SPC). Heavy tails, multimodality, nonlinear dependencies, and sparse special-cause observations can distort baseline estimation, mask true anomalies, and prevent reliable identification of an in-control (IC) reference set. To address these challenges, we introduce VSCOUT, a distribution-free framework designed specifically for retrospective (Phase I) monitoring in high-dimensional settings. VSCOUT combines an Automatic Relevance Determination Variational Autoencoder (ARD-VAE) architecture with ensemble-based latent outlier filtering and changepoint detection. The ARD prior isolates the most informative latent dimensions, while the ensemble and changepoint filters identify pointwise and structural contamination within the determined latent space. A second-stage retraining step removes flagged observations and re-estimates the latent structure using only the retained inliers, mitigating masking and stabilizing the IC latent manifold. This two-stage refinement produces a clean and reliable IC baseline suitable for subsequent Phase II deployment. Extensive experiments across benchmark datasets demonstrate that VSCOUT achieves superior sensitivity to special-cause structure while maintaining controlled false alarms, outperforming classical SPC procedures, robust estimators, and modern machine-learning baselines. Its scalability, distributional flexibility, and resilience to complex contamination patterns position VSCOUT as a practical and effective method for retrospective modeling and anomaly detection in AI-enabled environments.

--Anomaly Detection (AD) defines the task of identifying observations or events that deviate from typical - or normal - patterns, a critical capability in IT security for recognizing incidents such as system misconfigurations, malware infections, or cyberattacks. In enterprise environments like SAP HANA Cloud systems, this task often involves monitoring high-dimensional, multivariate time series (MTS) derived from telemetry and log data. One approach is the Quantum Autoencoder (QAE), an emerging and promising method with potential for application in both data compression and AD. However, prior applications of QAEs to time series AD have been restricted to univariate data, limiting their relevance for real-world enterprise systems. In this work, we introduce a novel QAE-based framework designed specifically for MTS AD towards enterprise scale. We theoretically develop and experimentally validate the architecture, demonstrating that our QAE achieves performance competitive with neural-network-based autoencoders while requiring fewer trainable parameters. We evaluate our model on datasets that closely reflect SAP system telemetry and show that the proposed QAE is a viable and efficient alternative for semisupervised AD in real-world enterprise settings. Anomaly Detection (AD) refers to the process of identifying patterns or events that deviate from typical - or normal - behavior [1]. It plays a critical role in IT security and many other domains, as anomalies often correspond to potential security breaches, frauds, or system failures [2], [3]. Modern enterprise infrastructure, such as SAP HANA Cloud and other large scale cloud native applications, rely on continuous monitoring to ensure optimal performance, availability, and reliability. With increasing system complexity and scale, observability platforms generate large volumes of telemetry data, including structured multivariate time series (MTS) and unstructured log streams.

Understanding user intent is essential for situational and context-aware decision-making. Motivated by a real-world scenario, this work addresses intent predictions of smart device users in the vicinity of vehicles by modeling sequential spatiotemporal data. However, in real-world scenarios, environmental factors and sensor limitations can result in non-stationary and irregularly sampled data, posing significant challenges. To address these issues, we propose STaRFormer, a Transformer-based approach that can serve as a universal framework for sequential modeling. STaRFormer utilizes a new dynamic attention-based regional masking scheme combined with a novel semi-supervised contrastive learning paradigm to enhance task-specific latent representations. Comprehensive experiments on 56 datasets varying in types (including non-stationary and irregularly sampled), tasks, domains, sequence lengths, training samples, and applications demonstrate the efficacy of STaRFormer, achieving notable improvements over state-of-the-art approaches.

Virtual cell modeling aims to predict cellular responses to perturbations. Existing virtual cell models rely heavily on large-scale single-cell datasets, learning explicit mappings between gene expression and perturbations. Although recent models attempt to incorporate multi-source biological information, their generalization remains constrained by data quality, coverage, and batch effects. More critically, these models often function as black boxes, offering predictions without interpretability or consistency with biological principles, which undermines their credibility in scientific research. To address these challenges, we present VCWorld, a cell-level white-box simulator that integrates structured biological knowledge with the iterative reasoning capabilities of large language models to instantiate a biological world model. VCWorld operates in a data-efficient manner to reproduce perturbation-induced signaling cascades and generates interpretable, stepwise predictions alongside explicit mechanistic hypotheses. In drug perturbation benchmarks, VCWorld achieves state-of-the-art predictive performance, and the inferred mechanistic pathways are consistent with publicly available biological evidence.

Abstract-- Detecting anomalies in multivariate time series is essential for monitoring complex industrial systems, where high dimensionality, limited labeled data, and subtle dependencies between sensors cause significant challenges. This paper presents a deep reinforcement learning framework that combines a V ari-ational Autoencoder (V AE), an LSTM-based Deep Q-Network (DQN), dynamic reward shaping, and an active learning module to address these issues in a unified learning framework. The main contribution is the implementation of Dynamic Reward Scaling for Multivariate Time Series Anomaly Detection (DRSMT), which demonstrates how each component enhances the detection process. The V AE captures compact latent representations and reduces noise. The DQN enables adaptive, sequential anomaly classification, and the dynamic reward shaping balances exploration and exploitation during training by adjusting the importance of reconstruction and classification signals. In addition, active learning identifies the most uncertain samples for labeling, reducing the need for extensive manual supervision. Experiments on two multivariate benchmarks, namely Server Machine Dataset (SMD) and Water Distribution T estbed (W ADI), show that the proposed method outperforms existing baselines in F1-score and AU-PR. In many of today's applications, identifying and removing anomalies (i.e., outliers) has become essential to ensure system reliability. In multivariate time series data, specifically, different factors can result in anomalies.

Cognitive workload is a topic of increasing interest across various fields such as health, psychology, and defense applications. In this research, we focus on classifying cognitive workload using the COLET dataset, employing a window-based approach for feature generation and machine/deep learning techniques for classification. We apply window-based temporal partitioning to enhance features used in existing research, followed by machine learning and deep learning models to classify different levels of cognitive workload. The results demonstrate that deep learning models, particularly tabular architectures, outperformed traditional machine learning methods in precision, F1-score, accuracy, and classification precision. This study highlights the effectiveness of window-based temporal feature extraction and the potential of deep learning techniques for real-time cognitive workload assessment in complex and dynamic tasks.

Removing Personally Identifiable Information (PII) from clinical notes in Electronic Health Records (EHRs) is essential for research and AI development. While Large Language Models (LLMs) are powerful, their high computational costs and the data privacy risks of API-based services limit their use, especially in low-resource settings. To address this, we developed LOGICAL (Local Obfuscation by GLINER for Impartial Context-Aware Lineage), an efficient, locally deployable PII removal system built on a fine-tuned Generalist and Lightweight Named Entity Recognition (GLiNER) model. We used 1515 clinical documents from a psychiatric hospital's EHR system. We defined nine PII categories for removal. A modern-gliner-bi-large-v1.0 model was fine-tuned on 2849 text instances and evaluated on a test set of 376 instances using character-level precision, recall, and F1-score. We compared its performance against Microsoft Azure NER, Microsoft Presidio, and zero-shot prompting with Gemini-Pro-2.5 and Llama-3.3-70B-Instruct. The fine-tuned GLiNER model achieved superior performance, with an overall micro-average F1-score of 0.980, significantly outperforming Gemini-Pro-2.5 (F1-score: 0.845). LOGICAL correctly sanitised 95% of documents completely, compared to 64% for the next-best solution. The model operated efficiently on a standard laptop without a dedicated GPU. However, a 2% entity-level false negative rate underscores the need for human-in-the-loop validation across all tested systems. Fine-tuned, specialised transformer models like GLiNER offer an accurate, computationally efficient, and secure solution for PII removal from clinical notes. This "sanitisation at the source" approach is a practical alternative to resource-intensive LLMs, enabling the creation of de-identified datasets for research and AI development while preserving data privacy, particularly in resource-constrained environments.