original article research paper
Daily Digest January 28, 2019 – BioDecoded
A cancer-fighting virus has shown some promise against a devastating childhood tumour of the eye. Retinoblastomas are tumours of the developing retina that sometimes result in surgical removal of the eye. This cancer is often caused by mutations that alter a tumour-suppressing protein called RB1. Researchers tested the effects of a genetically engineered virus that infects cancer cells that exhibit altered RB1 activity. The team cultured cells from 12 retinoblastoma samples and found that the virus infected and killed cells in 11 of these cultures.