Physics-informed machine learning (physics-ML) is transforming high-performance computing (HPC) simulation workflows across disciplines, including computational fluid dynamics, structural mechanics, and computational chemistry. Because of its broad applications, physics-ML is well suited for modeling physical systems and deploying digital twins across industries ranging from manufacturing to climate sciences. NVIDIA Modulus is a state-of-the-art physics-ML platform that blends physics with deep learning training data to build high-fidelity, parameterized surrogate models with near-real-time latency. The surrogate models built using NVIDIA Modulus help a wide range of solutions including weather forecasting, reducing power plant greenhouse gasses, and accelerating clean energy transitions. NVIDIA Modulus customer success stories are proving the platform's incredible utility across industries.