Here we compute the mean and standard deviation across seeds. Model Robustness score Baseline 100% MTL with real responses 109% MTL with predicted responses (MTL-Monkey) 118% MTL with shuffled predicted responses (MTL-Shuffled) 98% Table 3: Comparing our MTL model co-trained on predicted neural responses -MTL-Monkey in the paper-to the MTL model co-trained directly on real monkey V1 responses. We computed the robustness score of each model after averaging the accuracies of 3 seeds per model for each corruption type in TIN-TC and normalizing against the baseline test accuracies, i.e. the baseline score is 100%. We find that we can obtain a general increase in robustness when using real neural data. However, co-training on predicted neural responses improves the robustness of the models even more.

However, co-training on predicted neural responses improves the robustness of the models even more. We believe,thisisbecause theMTL-Monkeymodel usesthesameimages, i.e. tinyImageNet images amounting to100k images,for both tasks, namely neural prediction and image classification. In order to achieve this, we built a new model, starting with a random VGG, and fine-tuned the early layers (up toconv-3-1) to predict the actual neuronal data. Wenoticedthatthelowest resolution values are associated with the highest classification accuracies and vice versa. Stimulus presentation The stimuli were presented on a16:9 HDLCD monitor, with arefresh rate of 100 Hz, with a resolution of 1920x1080 pixels.

The representations of neural networks are often compared to those of biological systems by performing regression between the neural network responses and those measured from biological systems. Many different state-of-the-art deep neural networks yield similar neural predictions, but it remains unclear how to differentiate among models that perform equally well at predicting neural responses. To gain insight into this, we use a recent theoretical framework that relates the generalization error from regression to the spectral properties of the model and the target. We apply this theory to the case of regression between model activations and neural responses and decompose the neural prediction error in terms of the model eigenspectra, alignment of model eigenvectors and neural responses, and the training set size. Using this decomposition, we introduce geometrical measures to interpret the neural prediction error. We test a large number of deep neural networks that predict visual cortical activity and show that there are multiple types of geometries that result in low neural prediction error as measured via regression. The work demonstrates that carefully decomposing representational metrics can provide interpretability of how models are capturing neural activity and points the way towards improved models of neural activity.

Neural prediction offers a promising approach to forecasting the individual variability of neurocognitive functions and disorders and providing prognostic indicators for personalized invention. However, it is challenging to translate neural predictive models into medical artificial intelligent applications due to the limitations of domain shift and label scarcity. Here, we propose the directed evolution model (DEM), a novel computational model that mimics the trial-and-error processes of biological directed evolution to approximate optimal solutions for predictive modeling tasks. We demonstrated that the directed evolution algorithm is an effective strategy for uncertainty exploration, enhancing generalization in reinforcement learning. Furthermore, by incorporating replay buffer and continual backpropagate methods into DEM, we provide evidence of achieving better trade-off between exploitation and exploration in continuous learning settings. We conducted experiments on four different datasets for children with cochlear implants whose spoken language developmental outcomes vary considerably on the individual-child level. Preoperative neural MRI data has shown to accurately predict the post-operative outcome of these children within but not across datasets. Our results show that DEM can efficiently improve the performance of cross-domain pre-implantation neural predictions while addressing the challenge of label scarcity in target domain.

High-dimensional imaging of neural activity, such as widefield calcium and functional ultrasound imaging, provide a rich source of information for understanding the relationship between brain activity and behavior. Accurately modeling neural dynamics in these modalities is crucial for understanding this relationship but is hindered by the high-dimensionality, complex spatiotemporal dependencies, and prevalent behaviorally irrelevant dynamics in these modalities. Existing dynamical models often employ preprocessing steps to obtain low-dimensional representations from neural image modalities. However, this process can discard behaviorally relevant information and miss spatiotemporal structure. We propose SBIND, a novel data-driven deep learning framework to model spatiotemporal dependencies in neural images and disentangle their behaviorally relevant dynamics from other neural dynamics. We validate SBIND on widefield imaging datasets, and show its extension to functional ultrasound imaging, a recent modality whose dynamical modeling has largely remained unexplored. We find that our model effectively identifies both local and long-range spatial dependencies across the brain while also dissociating behaviorally relevant neural dynamics. Doing so, SBIND outperforms existing models in neural-behavioral prediction. Overall, SBIND provides a versatile tool for investigating the neural mechanisms underlying behavior using imaging modalities.

Uncertainty learning and quantification of models are crucial tasks to enhance the trustworthiness of the models. Importantly, the recent surge of generative language models (GLMs) emphasizes the need for reliable uncertainty quantification due to the concerns on generating hallucinated facts. In this paper, we propose to learn neural prediction set models that comes with the probably approximately correct (PAC) guarantee for quantifying the uncertainty of GLMs. Unlike existing prediction set models, which are parameterized by a scalar value, we propose to parameterize prediction sets via neural networks, which achieves more precise uncertainty quantification but still satisfies the PAC guarantee. We demonstrate the efficacy of our method on four types of language datasets and six types of models by showing that our method improves the quantified uncertainty by $63\%$ on average, compared to a standard baseline method.

Despite significant progress in the development of neural-symbolic frameworks, the question of how to integrate a neural and a symbolic system in a \emph{compositional} manner remains open. Our work seeks to fill this gap by treating these two systems as black boxes to be integrated as modules into a single architecture, without making assumptions on their internal structure and semantics. Instead, we expect only that each module exposes certain methods for accessing the functions that the module implements: the symbolic module exposes a deduction method for computing the function's output on a given input, and an abduction method for computing the function's inputs for a given output; the neural module exposes a deduction method for computing the function's output on a given input, and an induction method for updating the function given input-output training instances. We are, then, able to show that a symbolic module -- with any choice for syntax and semantics, as long as the deduction and abduction methods are exposed -- can be cleanly integrated with a neural module, and facilitate the latter's efficient training, achieving empirical performance that exceeds that of previous work.