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Quantifying Clinician Bias and its Effects on Schizophrenia Diagnosis in the Emergency Department of the Mount Sinai Health System

Valentine, Alissa A., Lepow, Lauren A., Chan, Lili, Charney, Alexander W., Landi, Isotta

arXiv.org Artificial Intelligence

In the United States, schizophrenia (SCZ) carries a race and sex disparity that may be explained by clinician bias - a belief held by a clinician about a patient that prevents impartial clinical decision making. The emergency department (ED) is marked by higher rates of stress that lead to clinicians relying more on implicit biases during decision making. In this work, we considered a large cohort of psychiatric patients in the ED from the Mount Sinai Health System (MSHS) in New York City to investigate the effects of clinician bias on SCZ diagnosis while controlling for known risk factors and patient sociodemographic information. Clinician bias was quantified as the ratio of negative to total sentences within a patient's first ED note. We utilized a logistic regression to predict SCZ diagnosis given patient race, sex, age, history of trauma or substance use disorder, and the ratio of negative sentences. Our findings showed that an increased ratio of negative sentences is associated with higher odds of obtaining a SCZ diagnosis [OR (95% CI)=1.408 (1.361-1.456)]. Identifying as male [OR (95% CI)=1.112 (1.055-1.173)] or Black [OR (95% CI)=1.081(1.031-1.133)] increased one's odds of being diagnosed with SCZ. However, from an intersectional lens, Black female patients with high SES have the highest odds of obtaining a SCZ diagnosis [OR (95% CI)=1.629 (1.535-1.729)]. Results such as these suggest that SES does not act as a protective buffer against SCZ diagnosis in all patients, demanding more attention to the quantification of health disparities. Lastly, we demonstrated that clinician bias is operational with real world data and related to increased odds of obtaining a stigmatizing diagnosis such as SCZ.


Deep Learning Characterizes Depression and Suicidal Ideation from Eye Movements

Avramidis, Kleanthis, Jeong, Woojae, Kommineni, Aditya, Kadiri, Sudarsana R., Ma, Marcus, McDaniel, Colin, Hughes, Myzelle, McGee, Thomas, Kaiser, Elsi, Byrd, Dani, Habibi, Assal, Cahn, B. Rael, Blank, Idan A., Lerman, Kristina, Medani, Takfarinas, Leahy, Richard M., Narayanan, Shrikanth

arXiv.org Artificial Intelligence

Identifying physiological and behavioral markers for mental health conditions is a longstanding challenge in psychiatry. Depression and suicidal ideation, in particular, lack objective biomarkers, with screening and diagnosis primarily relying on self-reports and clinical interviews. Here, we investigate eye tracking as a potential marker modality for screening purposes. Eye movements are directly modulated by neuronal networks and have been associated with attentional and mood-related patterns; however, their predictive value for depression and suicidality remains unclear. We recorded eye-tracking sequences from 126 young adults as they read and responded to affective sentences, and subsequently developed a deep learning framework to predict their clinical status. The proposed model included separate branches for trials of positive and negative sentiment, and used 2D time-series representations to account for both intra-trial and inter-trial variations. We were able to identify depression and suicidal ideation with an area under the receiver operating curve (AUC) of 0.793 (95% CI: 0.765-0.819) against healthy controls, and suicidality specifically with 0.826 AUC (95% CI: 0.797-0.852). The model also exhibited moderate, yet significant, accuracy in differentiating depressed from suicidal participants, with 0.609 AUC (95% CI 0.571-0.646). Discriminative patterns emerge more strongly when assessing the data relative to response generation than relative to the onset time of the final word of the sentences. The most pronounced effects were observed for negative-sentiment sentences, that are congruent to depressed and suicidal participants. Our findings highlight eye tracking as an objective tool for mental health assessment and underscore the modulatory impact of emotional stimuli on cognitive processes affecting oculomotor control.


Domain Adaptation for Japanese Sentence Embeddings with Contrastive Learning based on Synthetic Sentence Generation

Chen, Zihao, Handa, Hisashi, Ohsaki, Miho, Shirahama, Kimiaki

arXiv.org Artificial Intelligence

Such sentence embeddings can be further enhanced by domain adaptation that adapts a backbone model to a specific domain. However, domain adaptation for low-resource languages like Japanese is often difficult due to the scarcity of large-scale labeled datasets. To overcome this, this paper introduces SDJC (Self-supervised Domain adaptation for Japanese sentence embeddings with Contrastive learning) that utilizes a data generator to generate sentences, which have the same syntactic structure to a sentence in an unlabeled specific domain corpus but convey different semantic meanings. Generated sentences are then used to boost contrastive learning that adapts a backbone model to accurately discriminate sentences in the specific domain. In addition, the components of SDJC like a backbone model and a method to adapt it need to be carefully selected, but no benchmark dataset is available for Japanese. Thus, a comprehensive Japanese STS (Semantic Textual Similarity) benchmark dataset is constructed by combining datasets machine-translated from English with existing datasets. The experimental results validates the effectiveness of SDJC on two domain-specific downstream tasks as well as the usefulness of the constructed dataset.


FlipAttack: Jailbreak LLMs via Flipping

Liu, Yue, He, Xiaoxin, Xiong, Miao, Fu, Jinlan, Deng, Shumin, Hooi, Bryan

arXiv.org Artificial Intelligence

This paper proposes a simple yet effective jailbreak attack named FlipAttack against black-box LLMs. First, from the autoregressive nature, we reveal that LLMs tend to understand the text from left to right and find that they struggle to comprehend the text when noise is added to the left side. Motivated by these insights, we propose to disguise the harmful prompt by constructing left-side noise merely based on the prompt itself, then generalize this idea to 4 flipping modes. Second, we verify the strong ability of LLMs to perform the text-flipping task, and then develop 4 variants to guide LLMs to denoise, understand, and execute harmful behaviors accurately. These designs keep FlipAttack universal, stealthy, and simple, allowing it to jailbreak black-box LLMs within only 1 query. Experiments on 8 LLMs demonstrate the superiority of FlipAttack. Remarkably, it achieves $\sim$98\% attack success rate on GPT-4o, and $\sim$98\% bypass rate against 5 guardrail models on average. The codes are available at GitHub\footnote{https://github.com/yueliu1999/FlipAttack}.


Prompt Compression with Context-Aware Sentence Encoding for Fast and Improved LLM Inference

Liskavets, Barys, Ushakov, Maxim, Roy, Shuvendu, Klibanov, Mark, Etemad, Ali, Luke, Shane

arXiv.org Artificial Intelligence

Large language models (LLMs) have triggered a new stream of research focusing on compressing the context length to reduce the computational cost while ensuring the retention of helpful information for LLMs to answer the given question. Token-based removal methods are one of the most prominent approaches in this direction, but risk losing the semantics of the context caused by intermediate token removal, especially under high compression ratios, while also facing challenges in computational efficiency. In this work, we propose context-aware prompt compression (CPC), a sentence-level prompt compression technique where its key innovation is a novel context-aware sentence encoder that provides a relevance score for each sentence for a given question. To train this encoder, we generate a new dataset consisting of questions, positives, and negative pairs where positives are sentences relevant to the question, while negatives are irrelevant context sentences. We train the encoder in a contrastive setup to learn context-aware sentence representations. Our method considerably outperforms prior works on prompt compression on benchmark datasets and is up to 10.93x faster at inference compared to the best token-level compression method. We also find better improvement for shorter length constraints in most benchmarks, showing the effectiveness of our proposed solution in the compression of relevant information in a shorter context. Finally, we release the code and the dataset for quick reproducibility and further development: https://github.com/Workday/cpc.


SetBERT: Enhancing Retrieval Performance for Boolean Logic and Set Operation Queries

Mai, Quan, Gauch, Susan, Adams, Douglas

arXiv.org Artificial Intelligence

We introduce SetBERT, a fine-tuned BERT-based model designed to enhance query embeddings for set operations and Boolean logic queries, such as Intersection (AND), Difference (NOT), and Union (OR). SetBERT significantly improves retrieval performance for logic-structured queries, an area where both traditional and neural retrieval methods typically underperform. We propose an innovative use of inversed-contrastive loss, focusing on identifying the negative sentence, and fine-tuning BERT with a dataset generated via prompt GPT. Furthermore, we demonstrate that, unlike other BERT-based models, fine-tuning with triplet loss actually degrades performance for this specific task. Our experiments reveal that SetBERT-base not only significantly outperforms BERT-base (up to a 63% improvement in Recall) but also achieves performance comparable to the much larger BERT-large model, despite being only one-third the size.


Low-resource classification of mobility functioning information in clinical sentences using large language models

Le, Tuan Dung, Duong, Thanh, Thieu, Thanh

arXiv.org Artificial Intelligence

Objective: Function is increasingly recognized as an important indicator of whole-person health. This study evaluates the ability of publicly available large language models (LLMs) to accurately identify the presence of functioning information from clinical notes. We explore various strategies to improve the performance on this task. Materials and Methods: We collect a balanced binary classification dataset of 1000 sentences from the Mobility NER dataset, which was curated from n2c2 clinical notes. For evaluation, we construct zero-shot and few-shot prompts to query the LLMs whether a given sentence contains mobility functioning information. Two sampling techniques, random sampling and k-nearest neighbor (kNN)-based sampling, are used to select the few-shot examples. Furthermore, we apply a parameter-efficient prompt-based fine-tuning method to the LLMs and evaluate their performance under various training settings. Results: Flan-T5-xxl outperforms all other models in both zero-shot and few-shot settings, achieving a F1 score of 0.865 with a single demonstrative example selected by kNN sampling. In prompt-based fine-tuning experiments, this foundation model also demonstrates superior performance across all low-resource settings, particularly achieving an impressive F1 score of 0.922 using the full training dataset. The smaller model, Flan-T5-xl, requires fine-tuning with only 2.3M additional parameters to achieve comparable performance to the fully fine-tuned Gatortron-base model, both surpassing 0.9 F1 score. Conclusion: Open-source instruction-tuned LLMs demonstrate impressive in-context learning capability in the mobility functioning classification task. The performance of these models can be further improved by continuing fine-tuning on a task-specific dataset.


This is not a Dataset: A Large Negation Benchmark to Challenge Large Language Models

García-Ferrero, Iker, Altuna, Begoña, Álvez, Javier, Gonzalez-Dios, Itziar, Rigau, German

arXiv.org Artificial Intelligence

Although large language models (LLMs) have apparently acquired a certain level of grammatical knowledge and the ability to make generalizations, they fail to interpret negation, a crucial step in Natural Language Processing. We try to clarify the reasons for the sub-optimal performance of LLMs understanding negation. We introduce a large semi-automatically generated dataset of circa 400,000 descriptive sentences about commonsense knowledge that can be true or false in which negation is present in about 2/3 of the corpus in different forms. We have used our dataset with the largest available open LLMs in a zero-shot approach to grasp their generalization and inference capability and we have also fine-tuned some of the models to assess whether the understanding of negation can be trained. Our findings show that, while LLMs are proficient at classifying affirmative sentences, they struggle with negative sentences and lack a deep understanding of negation, often relying on superficial cues. Although fine-tuning the models on negative sentences improves their performance, the lack of generalization in handling negation is persistent, highlighting the ongoing challenges of LLMs regarding negation understanding and generalization. The dataset and code are publicly available.


Sentiment Analysis in the Era of Large Language Models: A Reality Check

Zhang, Wenxuan, Deng, Yue, Liu, Bing, Pan, Sinno Jialin, Bing, Lidong

arXiv.org Artificial Intelligence

Sentiment analysis (SA) has been a long-standing research area in natural language processing. It can offer rich insights into human sentiments and opinions and has thus seen considerable interest from both academia and industry. With the advent of large language models (LLMs) such as ChatGPT, there is a great potential for their employment on SA problems. However, the extent to which existing LLMs can be leveraged for different sentiment analysis tasks remains unclear. This paper aims to provide a comprehensive investigation into the capabilities of LLMs in performing various sentiment analysis tasks, from conventional sentiment classification to aspect-based sentiment analysis and multifaceted analysis of subjective texts. We evaluate performance across 13 tasks on 26 datasets and compare the results against small language models (SLMs) trained on domain-specific datasets. Our study reveals that while LLMs demonstrate satisfactory performance in simpler tasks, they lag behind in more complex tasks requiring deeper understanding or structured sentiment information. However, LLMs significantly outperform SLMs in few-shot learning settings, suggesting their potential when annotation resources are limited. We also highlight the limitations of current evaluation practices in assessing LLMs' SA abilities and propose a novel benchmark, \textsc{SentiEval}, for a more comprehensive and realistic evaluation. Data and code during our investigations are available at \url{https://github.com/DAMO-NLP-SG/LLM-Sentiment}.


Metric-guided Distillation: Distilling Knowledge from the Metric to Ranker and Retriever for Generative Commonsense Reasoning

He, Xingwei, Gong, Yeyun, Jin, A-Long, Qi, Weizhen, Zhang, Hang, Jiao, Jian, Zhou, Bartuer, Cheng, Biao, Yiu, SM, Duan, Nan

arXiv.org Artificial Intelligence

Commonsense generation aims to generate a realistic sentence describing a daily scene under the given concepts, which is very challenging, since it requires models to have relational reasoning and compositional generalization capabilities. Previous work focuses on retrieving prototype sentences for the provided concepts to assist generation. They first use a sparse retriever to retrieve candidate sentences, then re-rank the candidates with a ranker. However, the candidates returned by their ranker may not be the most relevant sentences, since the ranker treats all candidates equally without considering their relevance to the reference sentences of the given concepts. Another problem is that re-ranking is very expensive, but only using retrievers will seriously degrade the performance of their generation models. To solve these problems, we propose the metric distillation rule to distill knowledge from the metric (e.g., BLEU) to the ranker. We further transfer the critical knowledge summarized by the distilled ranker to the retriever. In this way, the relevance scores of candidate sentences predicted by the ranker and retriever will be more consistent with their quality measured by the metric. Experimental results on the CommonGen benchmark verify the effectiveness of our proposed method: (1) Our generation model with the distilled ranker achieves a new state-of-the-art result. (2) Our generation model with the distilled retriever even surpasses the previous SOTA.