The Negative selection Algorithm (NSA) is one of the important methods in the field of Immunological Computation (or Artificial Immune Systems). Over the years, some progress was made which turns this algorithm (NSA) into an efficient approach to solve problems in different domain. This review takes into account these signs of progress during the last decade and categorizes those based on different characteristics and performances. Our study shows that NSA's evolution can be labeled in four ways highlighting the most notable NSA variations and their limitations in different application domains. We also present alternative approaches to NSA for comparison and analysis. It is evident that NSA performs better for nonlinear representation than most of the other methods, and it can outperform neural-based models in computation time. We summarize NSA's development and highlight challenges in NSA research in comparison with other similar models.

In this paper, we propose a new methodology based on the Negative Selection Algorithm that belongs to the field of Computational Intelligence, specifically, Artificial Immune Systems to identify takeover targets. Although considerable research based on customary statistical techniques and some contemporary Computational Intelligence techniques have been devoted to identify takeover targets, most of the existing studies are based upon multiple previous mergers and acquisitions. Contrary to previous research, the novelty of this proposal lies in its ability to suggest takeover targets for novice firms that are at the beginning of their merger and acquisition spree. We first discuss the theoretical perspective and then provide a case study with details for practical implementation, both capitalizing from unique generalization capabilities of artificial immune systems algorithms.