Since annotating medical images for segmentation tasks commonly incurs expensive costs, it is highly desirable to design an annotation-efficient method to alleviate the annotation burden. Recently, contrastive learning has exhibited a great potential in learning robust representations to boost downstream tasks with limited labels. In medical imaging scenarios, ready-made meta labels (i.e., specific attribute information of medical images) inherently reveal semantic relationships among images, which have been used to define positive pairs in previous work. However, the multi-perspective semantics revealed by various meta labels are usually incompatible and can incur intractable "semantic contradiction" when combining different meta labels. In this paper, we tackle the issue of "semantic contradiction" in a gradient-guided manner using our proposed Gradient Mitigator method, which systematically unifies multi-perspective meta labels to enable a pre-trained model to attain a better high-level semantic recognition ability. Moreover, we emphasize that the fine-grained discrimination ability is vital for segmentation-oriented pre-training, and develop a novel method called Gradient Filter to dynamically screen pixel pairs with the most discriminating power based on the magnitude of gradients. Comprehensive experiments on four medical image segmentation datasets verify that our new method GCL: (1) learns informative image representations and considerably boosts segmentation performance with limited labels, and (2) shows promising generalizability on out-of-distribution datasets.

This paper presents a novel meta learning framework for feature selection (FS) based on fuzzy similarity. The proposed method aims to recommend the best FS method from four candidate FS methods for any given dataset. This is achieved by firstly constructing a large training data repository using data synthesis. Six meta features that represent the characteristics of the training dataset are then extracted. The best FS method for each of the training datasets is used as the meta label. Both the meta features and the corresponding meta labels are subsequently used to train a classification model using a fuzzy similarity measure based framework. Finally the trained model is used to recommend the most suitable FS method for a given unseen dataset. This proposed method was evaluated based on eight public datasets of real-world applications. It successfully recommended the best method for five datasets and the second best method for one dataset, which outperformed any of the four individual FS methods. Besides, the proposed method is computationally efficient for algorithm selection, leading to negligible additional time for the feature selection process. Thus, the paper contributes a novel method for effectively recommending which feature selection method to use for any new given dataset.