Recent advances in large vision-language models (LVLMs) have demonstrated strong performance on general-purpose medical tasks. However, their effectiveness in specialized domains such as dentistry remains underexplored. In particular, panoramic X-rays, a widely used imaging modality in oral radiology, pose interpretative challenges due to dense anatomical structures and subtle pathological cues, which are not captured by existing medical benchmarks or instruction datasets. To this end, we introduce MMOral, the first large-scale multimodal instruction dataset and benchmark tailored for panoramic X-ray interpretation. MMOral consists of 20,563 annotated images paired with 1.3 million instruction-following instances across diverse task types, including attribute extraction, report generation, visual question answering, and image-grounded dialogue.

The data split details are presented in Tab 3.

The scarcity of data presents a critical obstacle to the efficacy of medical vision-language pre-training (VLP). A potential solution lies in the combination of datasets from various language communities.Nevertheless, the main challenge stems from the complexity of integrating diverse syntax and semantics, language-specific medical terminology, and culture-specific implicit knowledge. Therefore, one crucial aspect to consider is the presence of community bias caused by different languages.This paper presents a novel framework named Unifying Cross-Lingual Medical Vision-Language Pre-Training (\textbf{Med-UniC}), designed to integrate multi-modal medical data from the two most prevalent languages, English and Spanish. Specifically, we propose \textbf{C}ross-lingual \textbf{T}ext Alignment \textbf{R}egularization (\textbf{CTR}) to explicitly unify cross-lingual semantic representations of medical reports originating from diverse language communities.

The data split details are presented in Tab 3.

The increasing prevalence of retinal diseases poses a significant challenge to the healthcare system, as the demand for ophthalmologists surpasses the available workforce. This imbalance creates a bottleneck in diagnosis and treatment, potentially delaying critical care. Traditional methods of generating medical reports from retinal images rely on manual interpretation, which is time-consuming and prone to errors, further straining ophthalmologists' limited resources. This thesis investigates the potential of Artificial Intelligence (AI) to automate medical report generation for retinal images. AI can quickly analyze large volumes of image data, identifying subtle patterns essential for accurate diagnosis. By automating this process, AI systems can greatly enhance the efficiency of retinal disease diagnosis, reducing doctors' workloads and enabling them to focus on more complex cases. The proposed AI-based methods address key challenges in automated report generation: (1) A multi-modal deep learning approach captures interactions between textual keywords and retinal images, resulting in more comprehensive medical reports; (2) Improved methods for medical keyword representation enhance the system's ability to capture nuances in medical terminology; (3) Strategies to overcome RNN-based models' limitations, particularly in capturing long-range dependencies within medical descriptions; (4) Techniques to enhance the interpretability of the AI-based report generation system, fostering trust and acceptance in clinical practice. These methods are rigorously evaluated using various metrics and achieve state-of-the-art performance. This thesis demonstrates AI's potential to revolutionize retinal disease diagnosis by automating medical report generation, ultimately improving clinical efficiency, diagnostic accuracy, and patient care.

With the increasing popularity of large language models (LLMs) for a variety of tasks, there has been a growing interest in strategies that can predict which out of a set of LLMs will yield a successful answer at low cost. This problem promises to become more and more relevant as providers like Microsoft allow users to easily create custom LLM "assistants" specialized to particular types of queries. However, some tasks (i.e., queries) may be too specialized and difficult for a single LLM to handle alone. These applications often benefit from breaking down the task into smaller subtasks, each of which can then be executed by a LLM expected to perform well on that specific subtask. For example, in extracting a diagnosis from medical records, one can first select an LLM to summarize the record, select another to validate the summary, and then select another, possibly different, LLM to extract the diagnosis from the summarized record. Unlike existing LLM selection or routing algorithms, this setting requires that we select a sequence of LLMs, with the output of each LLM feeding into the next and potentially influencing its success. Thus, unlike single LLM selection, the quality of each subtask's output directly affects the inputs, and hence the cost and success rate, of downstream LLMs, creating complex performance dependencies that must be learned and accounted for during selection. We propose a neural contextual bandit-based algorithm that trains neural networks that model LLM success on each subtask in an online manner, thus learning to guide the LLM selections for the different subtasks, even in the absence of historical LLM performance data. Experiments on telecommunications question answering and medical diagnosis prediction datasets illustrate the effectiveness of our proposed approach compared to other LLM selection algorithms.

Electronic medical reports (EHR) contain a vast amount of information that can be leveraged for machine learning applications in healthcare. However, existing survival analysis methods often struggle to effectively handle the complexity of textual data, particularly in its sequential form. Here, we propose SigBERT, an innovative temporal survival analysis framework designed to efficiently process a large number of clinical reports per patient. SigBERT processes timestamped medical reports by extracting and averaging word embeddings into sentence embeddings. To capture temporal dynamics from the time series of sentence embedding coordinates, we apply signature extraction from rough path theory to derive geometric features for each patient, which significantly enhance survival model performance by capturing complex temporal dynamics. These features are then integrated into a LASSO-penalized Cox model to estimate patient-specific risk scores. The model was trained and evaluated on a real-world oncology dataset from the Léon Bérard Center corpus, with a C-index score of 0.75 (sd 0.014) on the independent test cohort. SigBERT integrates sequential medical data to enhance risk estimation, advancing narrative-based survival analysis.

Automated radiology report generation (RRG) aims to produce detailed textual reports from clinical imaging, such as computed tomography (CT) scans, to improve the accuracy and efficiency of diagnosis and provision of management advice. RRG is complicated by two key challenges: (1) inherent complexity in extracting relevant information from imaging data under resource constraints, and (2) difficulty in objectively evaluating discrepancies between model-generated and expert-written reports. To address these challenges, we propose $μ^2$LLM, a $\underline{\textbf{mu}}$ltiscale $\underline{\textbf{mu}}$ltimodal large language models for RRG tasks. The novel $μ^2$Tokenizer, as an intermediate layer, integrates multi-modal features from the multiscale visual tokenizer and the text tokenizer, then enhances report generation quality through direct preference optimization (DPO), guided by GREEN-RedLlama. Experimental results on four large CT image-report medical datasets demonstrate that our method outperforms existing approaches, highlighting the potential of our fine-tuned $μ^2$LLMs on limited data for RRG tasks. At the same time, for prompt engineering, we introduce a five-stage, LLM-driven pipeline that converts routine CT reports into paired visual-question-answer triples and citation-linked reasoning narratives, creating a scalable, high-quality supervisory corpus for explainable multimodal radiology LLM. All code, datasets, and models will be publicly available in our official repository. https://github.com/Siyou-Li/u2Tokenizer

Clinical coding is a critical task in healthcare, although traditional methods for automating clinical coding may not provide sufficient explicit evidence for coders in production environments. This evidence is crucial, as medical coders have to make sure there exists at least one explicit passage in the input health record that justifies the attribution of a code. We therefore propose to reframe the task as an entity linking problem, in which each document is annotated with its set of codes and respective textual evidence, enabling better human-machine collaboration. By leveraging parameter-efficient fine-tuning of Large Language Models (LLMs), together with constrained decoding, we introduce three approaches to solve this problem that prove effective at disambiguating clinical mentions and that perform well in few-shot scenarios.

Deep networks for electroencephalogram (EEG) decoding are currently often trained to only solve a specific task like pathology or gender decoding. A more general approach leveraging the medical reports of clinical EEG recordings is to learn mappings between medical reports and EEG recordings. This approach was pioneered in the computer vision domain matching images and their text captions and subsequently allowed to do successful zero-shot decoding using textual class prompts. In this work, we follow this approach and develop a contrastive learning framework EEG-CLIP that aligns EEG time series and their corresponding clinical text descriptions in a shared embedding space. We investigate its potential for versatile EEG decoding, assessing performance on a range of few-shot and zero-shot settings. Overall, results show that EEG-CLIP manages to nontrivially align text and EEG representations. Our work presents a promising approach to learn general EEG representations, which could enable easier analyses of diverse decoding questions through zero shot decoding or training task-specific models from fewer training examples.