Interstitial lung disease (ILD) is a leading cause of morbidity and mortality in systemic sclerosis (SSc). Chest computed tomography (CT) is the primary imaging modality for diagnosing and monitoring lung complications in SSc patients. However, its role in disease progression and mortality prediction has not yet been fully clarified. This study introduces a novel, large-scale longitudinal chest CT analysis framework that utilizes radiomics and deep learning to predict mortality associated with lung complications of SSc. We collected and analyzed 2,125 CT scans from SSc patients enrolled in the Northwestern Scleroderma Registry, conducting mortality analyses at one, three, and five years using advanced imaging analysis techniques. Death labels were assigned based on recorded deaths over the one-, three-, and five-year intervals, confirmed by expert physicians. In our dataset, 181, 326, and 428 of the 2,125 CT scans were from patients who died within one, three, and five years, respectively. Using ResNet-18, DenseNet-121, and Swin Transformer we use pre-trained models, and fine-tuned on 2,125 images of SSc patients. Models achieved an AUC of 0.769, 0.801, 0.709 for predicting mortality within one-, three-, and five-years, respectively. Our findings highlight the potential of both radiomics and deep learning computational methods to improve early detection and risk assessment of SSc-related interstitial lung disease, marking a significant advancement in the literature.

Right heart failure (RHF) is a disease characterized by abnormalities in the structure or function of the right ventricle (RV), which is associated with high morbidity and mortality. Lung disease often causes increased right ventricular load, leading to RHF. Therefore, it is very important to screen out patients with cor pulmonale who develop RHF from people with underlying lung diseases. In this work, we propose a self-supervised representation learning method to early detecting RHF from patients with cor pulmonale, which uses spirogram time series to predict patients with RHF at an early stage. The proposed model is divided into two stages. The first stage is the self-supervised representation learning-based spirogram embedding (SLSE) network training process, where the encoder of the Variational autoencoder (VAE-encoder) learns a robust low-dimensional representation of the spirogram time series from the data-augmented unlabeled data. Second, this low-dimensional representation is fused with demographic information and fed into a CatBoost classifier for the downstream RHF prediction task. Trained and tested on a carefully selected subset of 26,617 individuals from the UK Biobank, our model achieved an AUROC of 0.7501 in detecting RHF, demonstrating strong population-level distinction ability. We further evaluated the model on high-risk clinical subgroups, achieving AUROC values of 0.8194 on a test set of 74 patients with chronic kidney disease (CKD) and 0.8413 on a set of 64 patients with valvular heart disease (VHD). These results highlight the model's potential utility in predicting RHF among clinically elevated-risk populations. In conclusion, this study presents a self-supervised representation learning approach combining spirogram time series and demographic data, demonstrating promising potential for early RHF detection in clinical practice.

The Los Angeles wildfires of January 2025 caused more than 250 billion dollars in damage and lasted for nearly an entire month before containment. Following our previous work, the Digital Twin Building, we modify and leverage the multi-agent large language model framework as well as the cloud-mapping integration to study the air quality during the Los Angeles wildfires. Recent advances in large language models have allowed for out-of-the-box automated large-scale data analysis. We use a multi-agent large language system comprised of an Instructor agent and Worker agents. Upon receiving the users' instructions, the Instructor agent retrieves the data from the cloud platform and produces instruction prompts to the Worker agents. The Worker agents then analyze the data and provide summaries. The summaries are finally input back into the Instructor agent, which then provides the final data analysis. We test this system's capability for data-based policy recommendation by assessing our Instructor-Worker LLM system's health recommendations based on air quality during the Los Angeles wildfires.

The lungs are the essential organs of respiration, and this system is significant in the carbon dioxide and exchange between oxygen that occurs in human life. However, several lung diseases, which include pneumonia, tuberculosis, COVID-19, and lung cancer, are serious healthiness challenges and demand early and precise diagnostics. The methodological study has proposed a new deep learning framework called NASNet-ViT, which effectively incorporates the convolution capability of NASNet with the global attention mechanism capability of Vision Transformer ViT. The proposed model will classify the lung conditions into five classes: Lung cancer, COVID-19, pneumonia, TB, and normal. A sophisticated multi-faceted preprocessing strategy called MixProcessing has been used to improve diagnostic accuracy. This preprocessing combines wavelet transform, adaptive histogram equalization, and morphological filtering techniques. The NASNet-ViT model performs at state of the art, achieving an accuracy of 98.9%, sensitivity of 0.99, an F1-score of 0.989, and specificity of 0.987, outperforming other state of the art architectures such as MixNet-LD, D-ResNet, MobileNet, and ResNet50. The model's efficiency is further emphasized by its compact size, 25.6 MB, and a low computational time of 12.4 seconds, hence suitable for real-time, clinically constrained environments. These results reflect the high-quality capability of NASNet-ViT in extracting meaningful features and recognizing various types of lung diseases with very high accuracy. This work contributes to medical image analysis by providing a robust and scalable solution for diagnostics in lung diseases.

This paper presents a comprehensive study on the classification and detection of Silicosis-related lung inflammation. Our main contributions include 1) the creation of a newly curated chest X-ray (CXR) image dataset named SVBCX that is tailored to the nuances of lung inflammation caused by distinct agents, providing a valuable resource for silicosis and pneumonia research community; and 2) we propose a novel deep-learning architecture that integrates graph transformer networks alongside a traditional deep neural network module for the effective classification of silicosis and pneumonia. Additionally, we employ the Balanced Cross-Entropy (BalCE) as a loss function to ensure more uniform learning across different classes, enhancing the model's ability to discern subtle differences in lung conditions. The proposed model architecture and loss function selection aim to improve the accuracy and reliability of inflammation detection, particularly in the context of Silicosis. Furthermore, our research explores the efficacy of an ensemble approach that combines the strengths of diverse model architectures. Experimental results on the constructed dataset demonstrate promising outcomes, showcasing substantial enhancements compared to baseline models. The ensemble of models achieves a macro-F1 score of 0.9749 and AUC ROC scores exceeding 0.99 for each class, underscoring the effectiveness of our approach in accurate and robust lung inflammation classification.

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context demonstrations and those with specialized medical fine-tuning, have demonstrated strong performance in medical language processing but struggle with real-time adaptability, multi-step reasoning, and handling complex medical tasks. Agent-based AI systems address these limitations by incorporating reasoning traces, tool selection based on context, knowledge retrieval, and both short- and long-term memory. These additional features enable the medical AI agent to handle complex medical scenarios where decision-making should be built on real-time interaction with the environment. Therefore, unlike conventional model-based approaches that treat medical queries as isolated questions, medical AI agents approach them as complex tasks and behave more like human doctors. In this paper, we study the choice of the backbone LLM for medical AI agents, which is the foundation for the agent's overall reasoning and action generation. In particular, we consider the emergent o1 model and examine its impact on agents' reasoning, tool-use adaptability, and real-time information retrieval across diverse clinical scenarios, including high-stakes settings such as intensive care units (ICUs). Our findings demonstrate o1's ability to enhance diagnostic accuracy and consistency, paving the way for smarter, more responsive AI tools that support better patient outcomes and decision-making efficacy in clinical practice.

Pulmonary diseases are a public health problem that requires accurate and fast diagnostic techniques. In this paper, a method based on convolutional neural networks (CNN), Data Augmentation, ResNet50 and Vision Transformers (ViT) is proposed to detect lung pathologies from medical images. A dataset of X-ray images and CT scans of patients with different lung diseases, such as cancer, pneumonia, tuberculosis and fibrosis, is used. The results obtained by the proposed method are compared with those of other existing methods, using performance metrics such as accuracy, sensitivity, specificity and area under the ROC curve. The results show that the proposed method outperforms the other methods in all metrics, achieving an accuracy of 98% and an area under the ROC curve of 99%. It is concluded that the proposed method is an effective and promising tool for the diagnosis of pulmonary pathologies by medical imaging.

In recent years, advancements in deep learning techniques have considerably enhanced the efficiency and accuracy of medical diagnostics. In this work, a novel approach using multi-task learning (MTL) for the simultaneous classification of lung sounds and lung diseases is proposed. Our proposed model leverages MTL with four different deep learning models such as 2D CNN, ResNet50, MobileNet and Densenet to extract relevant features from the lung sound recordings. The ICBHI 2017 Respiratory Sound Database was employed in the current study. The MTL for MobileNet model performed better than the other models considered, with an accuracy of74\% for lung sound analysis and 91\% for lung diseases classification. Results of the experimentation demonstrate the efficacy of our approach in classifying both lung sounds and lung diseases concurrently. In this study,using the demographic data of the patients from the database, risk level computation for Chronic Obstructive Pulmonary Disease is also carried out. For this computation, three machine learning algorithms namely Logistic Regression, SVM and Random Forest classifierswere employed. Among these ML algorithms, the Random Forest classifier had the highest accuracy of 92\%.This work helps in considerably reducing the physician's burden of not just diagnosing the pathology but also effectively communicating to the patient about the possible causes or outcomes.

Airway-related quantitative imaging biomarkers are crucial for examination, diagnosis, and prognosis in pulmonary diseases. However, the manual delineation of airway trees remains prohibitively time-consuming. While significant efforts have been made towards enhancing airway modelling, current public-available datasets concentrate on lung diseases with moderate morphological variations. The intricate honeycombing patterns present in the lung tissues of fibrotic lung disease patients exacerbate the challenges, often leading to various prediction errors. To address this issue, the 'Airway-Informed Quantitative CT Imaging Biomarker for Fibrotic Lung Disease 2023' (AIIB23) competition was organized in conjunction with the official 2023 International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). The airway structures were meticulously annotated by three experienced radiologists. Competitors were encouraged to develop automatic airway segmentation models with high robustness and generalization abilities, followed by exploring the most correlated QIB of mortality prediction. A training set of 120 high-resolution computerised tomography (HRCT) scans were publicly released with expert annotations and mortality status. The online validation set incorporated 52 HRCT scans from patients with fibrotic lung disease and the offline test set included 140 cases from fibrosis and COVID-19 patients. The results have shown that the capacity of extracting airway trees from patients with fibrotic lung disease could be enhanced by introducing voxel-wise weighted general union loss and continuity loss. In addition to the competitive image biomarkers for prognosis, a strong airway-derived biomarker (Hazard ratio>1.5, p<0.0001) was revealed for survival prognostication compared with existing clinical measurements, clinician assessment and AI-based biomarkers.

Chest X-rays remains to be the most common imaging modality used to diagnose lung diseases. However, they necessitate the interpretation of experts (radiologists and pulmonologists), who are few. This review paper investigates the use of deep transfer learning techniques to detect COVID-19, pneumonia, and tuberculosis in chest X-ray (CXR) images. It provides an overview of current state-of-the-art CXR image classification techniques and discusses the challenges and opportunities in applying transfer learning to this domain. The paper provides a thorough examination of recent research studies that used deep transfer learning algorithms for COVID-19, pneumonia, and tuberculosis detection, highlighting the advantages and disadvantages of these approaches. Finally, the review paper discusses future research directions in the field of deep transfer learning for CXR image classification, as well as the potential for these techniques to aid in the diagnosis and treatment of lung diseases.