Knee osteoarthritis (KOA) affects more than 600 million individuals globally and is associated with significant pain, functional impairment, and disability. While personalized multidisciplinary interventions have the potential to slow disease progression and enhance quality of life, they typically require substantial medical resources and expertise, making them difficult to implement in resource-limited settings. To address this challenge, we developed KOM, a multi-agent system designed to automate KOA evaluation, risk prediction, and treatment prescription. This system assists clinicians in performing essential tasks across the KOA care pathway and supports the generation of tailored management plans based on individual patient profiles, disease status, risk factors, and contraindications. In benchmark experiments, KOM demonstrated superior performance compared to several general-purpose large language models in imaging analysis and prescription generation. A randomized three-arm simulation study further revealed that collaboration between KOM and clinicians reduced total diagnostic and planning time by 38.5% and resulted in improved treatment quality compared to each approach used independently. These findings indicate that KOM could help facilitate automated KOA management and, when integrated into clinical workflows, has the potential to enhance care efficiency. The modular architecture of KOM may also offer valuable insights for developing AI-assisted management systems for other chronic conditions.

Knee osteoarthritis (KOA) is a universal chronic musculoskeletal disorders worldwide, making early diagnosis crucial. Currently, the Kellgren and Lawrence (KL) grading system is widely used to assess KOA severity. However, its high inter-observer variability and subjectivity hinder diagnostic consistency. To address these limitations, automated diagnostic techniques using deep learning have been actively explored in recent years. In this study, we propose a CLIP-based framework (CLIP-KOA) to enhance the consistency and reliability of KOA grade prediction. To achieve this, we introduce a learning approach that integrates image and text information and incorporate Symmetry Loss and Consistency Loss to ensure prediction consistency between the original and flipped images. CLIP-KOA achieves state-of-the-art accuracy of 71.86\% on KOA severity prediction task, and ablation studies show that CLIP-KOA has 2.36\% improvement in accuracy over the standard CLIP model due to our contribution. This study shows a novel direction for data-driven medical prediction not only to improve reliability of fine-grained diagnosis and but also to explore multimodal methods for medical image analysis. Our code is available at https://github.com/anonymized-link.

Diagnosing knee osteoarthritis (OA) early is crucial for managing symptoms and preventing further joint damage, ultimately improving patient outcomes and quality of life. In this paper, a bioimpedance-based diagnostic tool that combines precise hardware and deep learning for effective non-invasive diagnosis is proposed. system features a relay-based circuit and strategically placed electrodes to capture comprehensive bioimpedance data. The data is processed by a neural network model, which has been optimized using convolutional layers, dropout regularization, and the Adam optimizer. This approach achieves a 98% test accuracy, making it a promising tool for detecting knee osteoarthritis musculoskeletal disorders.

Knee osteoarthritis(KO) is a degenerative joint disease that can cause severe pain and impairment. With increased prevalence, precise diagnosis by medical imaging analytics is crucial for appropriate illness management. This research investigates a comparative analysis between traditional machine learning techniques and new deep learning models for diagnosing KO severity from X-ray pictures. This study does not introduce new architectural innovations but rather illuminates the robust applicability and comparative effectiveness of pre-existing ViT models in a medical imaging context, specifically for KO severity diagnosis. The insights garnered from this comparative analysis advocate for the integration of advanced ViT models in clinical diagnostic workflows, potentially revolutionizing the precision and reliability of KO assessments. This study does not introduce new architectural innovations but rather illuminates the robust applicability and comparative effectiveness of pre-existing ViT models in a medical imaging context, specifically for KO severity diagnosis. The insights garnered from this comparative analysis advocate for the integration of advanced ViT models in clinical diagnostic workflows, potentially revolutionizing the precision & reliability of KO assessments. The study utilizes an osteoarthritis dataset from the Osteoarthritis Initiative (OAI) comprising images with 5 severity categories and uneven class distribution. While classic machine learning models like GaussianNB and KNN struggle in feature extraction, Convolutional Neural Networks such as Inception-V3, VGG-19 achieve better accuracy between 55-65% by learning hierarchical visual patterns. However, Vision Transformer architectures like Da-VIT, GCViT and MaxViT emerge as indisputable champions, displaying 66.14% accuracy, 0.703 precision, 0.614 recall, AUC exceeding 0.835 thanks to self-attention processes.

Knee osteoarthritis (OA) is a widespread chronic condition that impairs mobility and diminishes quality of life. Despite the proven benefits of exercise therapy and patient education in managing the OA symptoms pain and functional limitations, these strategies are often underutilized. Personalized outcome prediction models can help motivate and engage patients, but the accuracy of existing models in predicting changes in knee pain remains insufficiently examined. To validate existing models and introduce a concise personalized model predicting changes in knee pain before to after participating in a supervised education and exercise therapy program (GLA:D) for knee OA patients. Our models use self-reported patient information and functional measures. To refine the number of variables, we evaluated the variable importance and applied clinical reasoning. We trained random forest regression models and compared the rate of true predictions of our models with those utilizing average values. We evaluated the performance of a full, continuous, and concise model including all 34, all 11 continuous, and the six most predictive variables respectively. All three models performed similarly and were comparable to the existing model, with R-squares of 0.31-0.32 and RMSEs of 18.65-18.85 - despite our increased sample size. Allowing a deviation of 15 VAS points from the true change in pain, our concise model and utilizing the average values estimated the change in pain at 58% and 51% correctly, respectively. Our supplementary analysis led to similar outcomes. Our concise personalized prediction model more accurately predicts changes in knee pain following the GLA:D program compared to average pain improvement values. Neither the increase in sample size nor the inclusion of additional variables improved previous models. To improve predictions, new variables beyond those in the GLA:D are required.

This research paper explores the classification of knee osteoarthritis (OA) severity levels using advanced computer vision models and augmentation techniques. The study investigates the effectiveness of data preprocessing, including Contrast-Limited Adaptive Histogram Equalization (CLAHE), and data augmentation using diffusion models. Three experiments were conducted: training models on the original dataset, training models on the preprocessed dataset, and training models on the augmented dataset. The results show that data preprocessing and augmentation significantly improve the accuracy of the models. The EfficientNetB3 model achieved the highest accuracy of 84\% on the augmented dataset. Additionally, attention visualization techniques, such as Grad-CAM, are utilized to provide detailed attention maps, enhancing the understanding and trustworthiness of the models. These findings highlight the potential of combining advanced models with augmented data and attention visualization for accurate knee OA severity classification.

Existing artificial intelligence (AI) models for diagnosing knee osteoarthritis (OA) have faced criticism for their lack of transparency and interpretability, despite achieving medical-expert-like performance. This opacity makes them challenging to trust in clinical practice. Recently, explainable artificial intelligence (XAI) has emerged as a specialized technique that can provide confidence in the model's prediction by revealing how the prediction is derived, thus promoting the use of AI systems in healthcare. This paper presents the first survey of XAI techniques used for knee OA diagnosis. The XAI techniques are discussed from two perspectives: data interpretability and model interpretability. The aim of this paper is to provide valuable insights into XAI's potential towards a more reliable knee OA diagnosis approach and encourage its adoption in clinical practice.

Background: MR-based subchondral bone effectively predicts knee osteoarthritis. However, its clinical application is limited by the cost and time of MR. Purpose: We aim to develop a novel distillation-learning-based method named SRRD for subchondral bone microstructural analysis using easily-acquired CT images, which leverages paired MR images to enhance the CT-based analysis model during training. Materials and Methods: Knee joint images of both CT and MR modalities were collected from October 2020 to May 2021. Firstly, we developed a GAN-based generative model to transform MR images into CT images, which was used to establish the anatomical correspondence between the two modalities. Next, we obtained numerous patches of subchondral bone regions of MR images, together with their trabecular parameters (BV / TV, Tb. Th, Tb. Sp, Tb. N) from the corresponding CT image patches via regression. The distillation-learning technique was used to train the regression model and transfer MR structural information to the CT-based model. The regressed trabecular parameters were further used for knee osteoarthritis classification. Results: A total of 80 participants were evaluated. CT-based regression results of trabecular parameters achieved intra-class correlation coefficients (ICCs) of 0.804, 0.773, 0.711, and 0.622 for BV / TV, Tb. Th, Tb. Sp, and Tb. N, respectively. The use of distillation learning significantly improved the performance of the CT-based knee osteoarthritis classification method using the CNN approach, yielding an AUC score of 0.767 (95% CI, 0.681-0.853) instead of 0.658 (95% CI, 0.574-0.742) (p<.001). Conclusions: The proposed SRRD method showed high reliability and validity in MR-CT registration, regression, and knee osteoarthritis classification, indicating the feasibility of subchondral bone microstructural analysis based on CT images.

Many variables of interest in clinical medicine, like disease severity, are recorded using discrete ordinal categories such as normal/mild/moderate/severe. These labels are used to train and evaluate disease severity prediction models. However, ordinal categories represent a simplification of an underlying continuous severity spectrum. Using continuous scores instead of ordinal categories is more sensitive to detecting small changes in disease severity over time. Here, we present a generalized framework that accurately predicts continuously valued variables using only discrete ordinal labels during model development. We found that for three clinical prediction tasks, models that take the ordinal relationship of the training labels into account outperformed conventional multi-class classification models. Particularly the continuous scores generated by ordinal classification and regression models showed a significantly higher correlation with expert rankings of disease severity and lower mean squared errors compared to the multi-class classification models. Furthermore, the use of MC dropout significantly improved the ability of all evaluated deep learning approaches to predict continuously valued scores that truthfully reflect the underlying continuous target variable. We showed that accurate continuously valued predictions can be generated even if the model development only involves discrete ordinal labels. The novel framework has been validated on three different clinical prediction tasks and has proven to bridge the gap between discrete ordinal labels and the underlying continuously valued variables.

Washington [US], December 17 (ANI): Researchers from the University of Jyvaskyla and the Central Finland Health Care District have developed an AI based neural network to detect an early knee osteoarthritis from x-ray images. AI was able to match a doctors' diagnosis in 87 per cent of cases. The result is important because x-rays are the primary diagnostic method for early knee osteoarthritis. An early diagnosis can save the patient from unnecessary examinations, treatments and even knee joint replacement surgery. Osteoarthritis is the most common joint-related ailment globally.