Our encoder-decoder architecture for a 3D input is shown in Fig. A.1. The architecture for a 2D input is the same, only using 2D convolutions and a 2D attribute space. Our generator takes in as input the content and attribute latent spaces. In addition, not shown in Fig. A.1, our domain discriminator contains 6 convolutional layers with Imaging phenotype variability is common in many neurological and psychiatric disorders, and is an important feature for diagnosis. This type of variation was simulated in Baumgartner et al.

The development of AI-based methods to analyze radiology reports could lead to significant advances in medical diagnosis, from improving diagnostic accuracy to enhancing efficiency and reducing workload. However, the lack of interpretability of AI-based methods could hinder their adoption in clinical settings. In this paper, we propose an interpretable-by-design framework for classifying chest radiology reports. First, we extract a set of representative facts from a large set of reports. Then, given a new report, we query whether a small subset of the representative facts is entailed by the report, and predict a diagnosis based on the selected subset of query-answer pairs. The explanation for a prediction is, by construction, the set of selected queries and answers. We use the Information Pursuit framework to select the most informative queries, a natural language inference model to determine if a fact is entailed by the report, and a classifier to predict the disease. Experiments on the MIMIC-CXR dataset demonstrate the effectiveness of the proposed method, highlighting its potential to enhance trust and usability in medical AI.

This paper proposes a model for simultaneous classification and feature attribution in the context of medical image classification. The model uses GAN to learn two representations from pairs (x, y) of input images of different classes. One representation is class-relevant (z a, a for attribution) and the other is class-irrelevant (z c, c for content). The class-relevant representation is used for classification. Both representations are fed to a generator G to synthesize images so as to achieve domain translation.

Rule-based models, e.g., decision trees, are widely used in scenarios demanding high model interpretability for their transparent inner structures and good model expressivity. However, rule-based models are hard to optimize, especially on large data sets, due to their discrete parameters and structures. Ensemble methods and fuzzy/soft rules are commonly used to improve performance, but they sacrifice the model interpretability. To obtain both good scalability and interpretability, we propose a new classifier, named Rule-based Representation Learner (RRL), that automatically learns interpretable non-fuzzy rules for data representation and classification. To train the non-differentiable RRL effectively, we project it to a continuous space and propose a novel training method, called Gradient Grafting, that can directly optimize the discrete model using gradient descent.

Feature attribution (FA), or the assignment of class-relevance to different locations in an image, is important for many classification problems but is particularly crucial within the neuroscience domain, where accurate mechanistic models of behaviours, or disease, require knowledge of all features discriminative of a trait. At the same time, predicting class relevance from brain images is challenging as phenotypes are typically heterogeneous, and changes occur against a background of significant natural variation. Here, we present a novel framework for creating class specific FA maps through image-to-image translation. We propose the use of a VAE-GAN to explicitly disentangle class relevance from background features for improved interpretability properties, which results in meaningful FA maps. We show that FA maps generated by our method outperform baseline FA methods when validated against ground truth. More significantly, our approach is the first to use latent space sampling to support exploration of phenotype variation.

The paper proposes learning sets of decision rules that can express the disjunction of feature values in atoms of the rules, for example, IF color yellow OR red, THEN stop. The emphasis is on interpretability, and the paper argues that these multi-value rules are more interpretable than similarly trained decision sets that do not support multi-value rules. Following prior work, the paper proposes placing a prior distribution over the parameters of the decision set, such as the number of rules and the maximum number of atoms in each rule. The paper derives bounds on the resulting distribution to accelerate a simulated annealing learning algorithm. Experiments show that multi-value rule sets are as accurate as other classifiers proposed as interpretable model classes, such as Bayesian rule sets on benchmark decision problems.

Wiki articles are created and maintained by a crowd of editors, producing a continuous stream of reviews. Reviews can take the form of additions, reverts, or both. This crowdsourcing model is exposed to manipulation since neither reviews nor editors are automatically screened and purged. To protect articles against vandalism or damage, the stream of reviews can be mined to classify reviews and profile editors in real-time. The goal of this work is to anticipate and explain which reviews to revert. This way, editors are informed why their edits will be reverted. The proposed method employs stream-based processing, updating the profiling and classification models on each incoming event. The profiling uses side and content-based features employing Natural Language Processing, and editor profiles are incrementally updated based on their reviews. Since the proposed method relies on self-explainable classification algorithms, it is possible to understand why a review has been classified as a revert or a non-revert. In addition, this work contributes an algorithm for generating synthetic data for class balancing, making the final classification fairer. The proposed online method was tested with a real data set from Wikivoyage, which was balanced through the aforementioned synthetic data generation. The results attained near-90 % values for all evaluation metrics (accuracy, precision, recall, and F-measure).

Label-free approaches are attractive in cytological imaging due to their flexibility and cost efficiency. They are supported by machine learning methods, which, despite the lack of labeling and the associated lower contrast, can classify cells with high accuracy where the human observer has little chance to discriminate cells. In order to better integrate these workflows into the clinical decision making process, this work investigates the calibration of confidence estimation for the automated classification of leukocytes. In addition, different visual explanation approaches are compared, which should bring machine decision making closer to professional healthcare applications. Furthermore, we were able to identify general detection patterns in neural networks and demonstrate the utility of the presented approaches in different scenarios of blood cell analysis.

Alzheimer's disease (AD) has a complex and multifactorial etiology, which requires integrating information about neuroanatomy, genetics, and cerebrospinal fluid biomarkers for accurate diagnosis. Hence, recent deep learning approaches combined image and tabular information to improve diagnostic performance. However, the black-box nature of such neural networks is still a barrier for clinical applications, in which understanding the decision of a heterogeneous model is integral. We propose PANIC, a prototypical additive neural network for interpretable AD classification that integrates 3D image and tabular data. It is interpretable by design and, thus, avoids the need for post-hoc explanations that try to approximate the decision of a network. Our results demonstrate that PANIC achieves state-of-the-art performance in AD classification, while directly providing local and global explanations. Finally, we show that PANIC extracts biologically meaningful signatures of AD, and satisfies a set of desirable desiderata for trustworthy machine learning. Our implementation is available at https://github.com/ai-med/PANIC .

How to interpret a data mining model has received much attention recently, because people may distrust a black-box predictive model if they do not understand how the model works. Hence, it will be trustworthy if a model can provide transparent illustrations on how to make the decision. Although many rule-based interpretable classification algorithms have been proposed, all these existing solutions cannot directly construct an interpretable model to provide personalized prediction for each individual test sample. In this paper, we make a first step towards formally introducing personalized interpretable classification as a new data mining problem to the literature. In addition to the problem formulation on this new issue, we present a greedy algorithm called PIC (Personalized Interpretable Classifier) to identify a personalized rule for each individual test sample. To demonstrate the necessity, feasibility and advantages of such a personalized interpretable classification method, we conduct a series of empirical studies on real data sets. The experimental results show that: (1) The new problem formulation enables us to find interesting rules for test samples that may be missed by existing non-personalized classifiers. (2) Our algorithm can achieve the same-level predictive accuracy as those state-of-the-art (SOTA) interpretable classifiers. (3) On a real data set for predicting breast cancer metastasis, such a personalized interpretable classifier can outperform SOTA methods in terms of both accuracy and interpretability.