Abstract: Hypergraph partitioning is an NP-hard problem that occurs in many computer science applications where it is necessary to reduce large problems into a number of smaller, computationally tractable sub-problems. Current techniques use a multilevel approach wherein an initial partitioning is performed after compressing the hypergraph to a predetermined level. This level is typically chosen to produce very coarse hypergraphs in which heuristic algorithms are fast and effective. This article presents a novel memetic algorithm which remains effective on larger initial hypergraphs. This enables the exploitation of information that can be lost during coarsening and results in improved final solution quality.