Dna demethylation is associated with malignant progression of lower-grade gliomas.

Hypergraphs are increasingly utilized in both unimodal and multimodal data scenarios due to their superior ability to model and extract higher-order relationships among nodes, compared to traditional graphs. However, current hypergraph models are encountering challenges related to imbalanced data, as this imbalance can lead to biases in the model towards the more prevalent classes. While the existing techniques, such as GraphSMOTE, have improved classification accuracy for minority samples in graph data, they still fall short when addressing the unique structure of hypergraphs. Inspired by SMOTE concept, we propose HyperSMOTE as a solution to alleviate the class imbalance issue in hypergraph learning. This method involves a two-step process: initially synthesizing minority class nodes, followed by the nodes integration into the original hypergraph. We synthesize new nodes based on samples from minority classes and their neighbors. At the same time, in order to solve the problem on integrating the new node into the hypergraph, we train a decoder based on the original hypergraph incidence matrix to adaptively associate the augmented node to hyperedges. We conduct extensive evaluation on multiple single-modality datasets, such as Cora, Cora-CA and Citeseer, as well as multimodal conversation dataset MELD to verify the effectiveness of HyperSMOTE, showing an average performance gain of 3.38% and 2.97% on accuracy, respectively.

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by varied social cognitive challenges and repetitive behavioral patterns. Identifying reliable brain imaging-based biomarkers for ASD has been a persistent challenge due to the spectrum's diverse symptomatology. Existing baselines in the field have made significant strides in this direction, yet there remains room for improvement in both performance and interpretability. We propose \emph{HyperGALE}, which builds upon the hypergraph by incorporating learned hyperedges and gated attention mechanisms. This approach has led to substantial improvements in the model's ability to interpret complex brain graph data, offering deeper insights into ASD biomarker characterization. Evaluated on the extensive ABIDE II dataset, \emph{HyperGALE} not only improves interpretability but also demonstrates statistically significant enhancements in key performance metrics compared to both previous baselines and the foundational hypergraph model. The advancement \emph{HyperGALE} brings to ASD research highlights the potential of sophisticated graph-based techniques in neurodevelopmental studies. The source code and implementation instructions are available at GitHub:https://github.com/mehular0ra/HyperGALE.

Conversational recommender system (CRS) interacts with users through multi-turn dialogues in natural language, which aims to provide high-quality recommendations for user's instant information need. Although great efforts have been made to develop effective CRS, most of them still focus on the contextual information from the current dialogue, usually suffering from the data scarcity issue. Therefore, we consider leveraging historical dialogue data to enrich the limited contexts of the current dialogue session. In this paper, we propose a novel multi-grained hypergraph interest modeling approach to capture user interest beneath intricate historical data from different perspectives. As the core idea, we employ hypergraph to represent complicated semantic relations underlying historical dialogues. In our approach, we first employ the hypergraph structure to model users' historical dialogue sessions and form a session-based hypergraph, which captures coarse-grained, session-level relations. Second, to alleviate the issue of data scarcity, we use an external knowledge graph and construct a knowledge-based hypergraph considering fine-grained, entity-level semantics. We further conduct multi-grained hypergraph convolution on the two kinds of hypergraphs, and utilize the enhanced representations to develop interest-aware CRS. Extensive experiments on two benchmarks ReDial and TG-ReDial validate the effectiveness of our approach on both recommendation and conversation tasks. Code is available at: https://github.com/RUCAIBox/MHIM.

Spatiotemporal activity prediction, aiming to predict user activities at a specific location and time, is crucial for applications like urban planning and mobile advertising. Existing solutions based on tensor decomposition or graph embedding suffer from the following two major limitations: 1) ignoring the fine-grained similarities of user preferences; 2) user's modeling is entangled. In this work, we propose a hypergraph neural network model called DisenHCN to bridge the above gaps. In particular, we first unify the fine-grained user similarity and the complex matching between user preferences and spatiotemporal activity into a heterogeneous hypergraph. We then disentangle the user representations into different aspects (location-aware, time-aware, and activity-aware) and aggregate corresponding aspect's features on the constructed hypergraph, capturing high-order relations from different aspects and disentangles the impact of each aspect for final prediction. Extensive experiments show that our DisenHCN outperforms the state-of-the-art methods by 14.23% to 18.10% on four real-world datasets. Further studies also convincingly verify the rationality of each component in our DisenHCN.

Recently, graph neural networks have attracted great attention and achieved prominent performance in various research fields. Most of those algorithms have assumed pairwise relationships of objects of interest. However, in many real applications, the relationships between objects are in higher-order, beyond a pairwise formulation. To efficiently learn deep embeddings on the high-order graph-structured data, we introduce two end-to-end trainable operators to the family of graph neural networks, i.e., hypergraph convolution and hypergraph attention. Whilst hypergraph convolution defines the basic formulation of performing convolution on a hypergraph, hypergraph attention further enhances the capacity of representation learning by leveraging an attention module. With the two operators, a graph neural network is readily extended to a more flexible model and applied to diverse applications where non-pairwise relationships are observed. Extensive experimental results with semi-supervised node classification demonstrate the effectiveness of hypergraph convolution and hypergraph attention.