Reinforcement learning models address animal's behavioral adaptation to its changing "external" environment, and are based on the assumption that Pavlovian, habitual and goal-directed responses seek to maximize reward acquisition. Negative-feedback models of homeostatic regulation, on the other hand, are concerned with behavioral adaptation in response to the "internal" state of the animal, and assume that animals' behavioral objective is to minimize deviations of some key physiological variables from their hypothetical setpoints. Building upon the drive-reduction theory of reward, we propose a new analytical framework that integrates learning and regulatory systems, such that the two seemingly unrelated objectives of reward maximization and physiological-stability prove to be identical. The proposed theory shows behavioral adaptation to both internal and external states in a disciplined way. We further show that the proposed framework allows for a unified explanation of some behavioral phenomenon like motivational sensitivity of different associative learning mechanism, anticipatory responses, interaction among competing motivational systems, and risk aversion.

Reinforcement learning models address animal's behavioral adaptation to its changing "external" environment, and are based on the assumption that Pavlovian, habitual and goal-directed responses seek to maximize reward acquisition. Negative-feedback models of homeostatic regulation, on the other hand, are concerned with behavioral adaptation in response to the "internal" state of the animal, and assume that animals' behavioral objective is to minimize deviations of some key physiological variables from their hypothetical setpoints. Building upon the drive-reduction theory of reward, we propose a new analytical framework that integrates learning and regulatory systems, such that the two seemingly unrelated objectives of reward maximization and physiological-stability prove to be identical. The proposed theory shows behavioral adaptation to both internal and external states in a disciplined way. We further show that the proposed framework allows for a unified explanation of some behavioral phenomenon like motivational sensitivity of different associative learning mechanism, anticipatory responses, interaction among competing motivational systems, and risk aversion.

The Charles Bonnet Syndrome (CBS) is characterized by complex vivid visual hallucinations in people with, primarily, eye diseases and no other neurological pathology. We present a Deep Boltzmann Machine model of CBS, exploring two core hypotheses: First, that the visual cortex learns a generative or predictive model of sensory input, thus explaining its capability to generate internal imagery. And second, that homeostatic mechanisms stabilize neuronal activity levels, leading to hallucinations being formed when input is lacking. We reproduce a variety of qualitative findings in CBS. We also introduce a modification to the DBM that allows us to model a possible role of acetylcholine in CBS as mediating the balance of feed-forward and feed-back processing. Our model might provide new insights into CBS and also demonstrates that generative frameworks are promising as hypothetical models of cortical learning and perception.