In recent years, deep learning (DL) approaches have demonstrated promising results in decoding hemodynamic responses captured by functional near-infrared spectroscopy (fNIRS), particularly in the context of brain-computer interface (BCI) applications. This work introduces AbsoluteNet, a novel deep learning architecture designed to classify auditory event-related responses recorded using fNIRS. The proposed network is built upon principles of spatio-temporal convolution and customized activation functions. Our model was compared against several models, namely fNIRSNET, MDNN, DeepConvNet, and ShallowConvNet. The results showed that AbsoluteNet outperforms existing models, reaching 87.0% accuracy, 84.8% sensitivity, and 89.2% specificity in binary classification, surpassing fNIRSNET, the second-best model, by 3.8% in accuracy. These findings underscore the effectiveness of our proposed deep learning model in decoding hemodynamic responses related to auditory processing and highlight the importance of spatio-temporal feature aggregation and customized activation functions to better fit fNIRS dynamics.

People with Multiple Sclerosis (MS) complain of problems with hand dexterity and cognitive fatigue. However, in many cases, impairments are subtle and difficult to detect. Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique that measures brain hemodynamic responses during cognitive or motor tasks. We aimed to detect brain activity biomarkers that could explain subjective reports of cognitive fatigue while completing dexterous tasks and provide targets for future brain stimulation treatments. We recruited 15 people with MS who did not have a hand (Nine Hole Peg Test [NHPT]), mobility, or cognitive impairment, and 12 age- and sex-matched controls. Participants completed two types of hand dexterity tasks with their dominant hand, single task and dual task (NHPT while holding a ball between the fifth finger and hypothenar eminence of the same hand). We analyzed fNIRS data (oxygenated and deoxygenated hemoglobin levels) using a machine learning framework to classify MS patients from controls based on their brain activation patterns in bilateral prefrontal and sensorimotor cortices. The K-Nearest Neighbor classifier achieved an accuracy of 75.0% for single manual dexterity tasks and 66.7% for the more complex dual manual dexterity tasks. Using XAI, we found that the most important brain regions contributing to the machine learning model were the supramarginal/angular gyri and the precentral gyrus (sensory integration and motor regions) of the ipsilateral hemisphere, with suppressed activity and slower neurovascular response in the MS group. During both tasks, deoxygenated hemoglobin levels were better predictors than the conventional measure of oxygenated hemoglobin. This nonconventional method of fNIRS data analysis revealed novel brain activity biomarkers that can help develop personalized brain stimulation targets.

We present a Hidden Markov Model (HMM) for inferring the hidden psychological state (or neural activity) during single trial tMRI activation experiments with blocked task paradigms. Inference is based on Bayesian methodology, using a combination of analytical and a variety of Markov Chain Monte Carlo (MCMC) sampling techniques. The advantage of this method is that detection of short time learning effects between repeated trials is possible since inference is based only on single trial experiments.

We present a Hidden Markov Model (HMM) for inferring the hidden psychological state (or neural activity) during single trial tMRI activation experiments with blocked task paradigms. Inference is based on Bayesian methodology, using a combination of analytical and a variety of Markov Chain Monte Carlo (MCMC) sampling techniques. The advantage of this method is that detection of short time learning effects between repeated trials is possible since inference is based only on single trial experiments.

We present a Hidden Markov Model (HMM) for inferring the hidden psychological state (or neural activity) during single trial tMRI activation experimentswith blocked task paradigms. Inference is based on Bayesian methodology, using a combination of analytical and a variety of Markov Chain Monte Carlo (MCMC) sampling techniques. The advantage ofthis method is that detection of short time learning effects between repeated trials is possible since inference is based only on single trial experiments.