Identifying reaction coordinates(RCs) is an active area of research, given the crucial role RCs play in determining the progress of a chemical reaction. The choice of the reaction coordinate is often based on heuristic knowledge. However, an essential criterion for the choice is that the coordinate should capture both the reactant and product states unequivocally. Also, the coordinate should be the slowest one so that all the other degrees of freedom can easily equilibrate along the reaction coordinate. Also, the coordinate should be the slowest one so that all the other degrees of freedom can easily equilibrate along the reaction coordinate. We used a regularised sparse autoencoder, an energy-based model, to discover a crucial set of reaction coordinates. Along with discovering reaction coordinates, our model also predicts the evolution of a molecular dynamics(MD) trajectory. We showcased that including sparsity enforcing regularisation helps in choosing a small but important set of reaction coordinates. We used two model systems to demonstrate our approach: alanine dipeptide system and proflavine and DNA system, which exhibited intercalation of proflavine into DNA minor groove in an aqueous environment. We model MD trajectory as a multivariate time series, and our latent variable model performs the task of multi-step time series prediction. This idea is inspired by the popular sparse coding approach - to represent each input sample as a linear combination of few elements taken from a set of representative patterns.

Artificial Intelligence is one of the branches of computer engineering that deals with the improvement of smart and self-operating machines.

The Canadian poet Dennis Lee once wrote that the consolations of existence might be improved if we thought, worked, and lived as though we were inhabiting "the early days of a better civilization." The test of this would be whether humans, separately and together, are able to generate and make better choices. This is as much a question about wisdom as it is about science. We don't find it too hard to imagine continued progress in science and technology. We can extrapolate from the experiences of the last century toward a more advanced civilization that simply knows more, can control more, and is less vulnerable to threats.

The Canadian poet Dennis Lee once wrote that the consolations of existence might be improved if we thought, worked, and lived as though we were inhabiting "the early days of a better civilization." The test of this would be whether humans, separately and together, are able to generate and make better choices. This is as much a question about wisdom as it is about science. We don't find it too hard to imagine continued progress in science and technology. We can extrapolate from the experiences of the last century toward a more advanced civilization that simply knows more, can control more, and is less vulnerable to threats. Indeed if humans have any sense, they will demand the best of what robots have--prosthetic limbs, synthetic eyes, and expanded memories--so that they can keep the interesting jobs along with the status and pay that goes with them as opposed to allowing these to be parceled out.