For decades, handmade narco subs have been some of the cocaine trade's most elusive and productive workhorses, ferrying multi-ton loads of illicit drugs from Colombian estuaries toward markets in North America and, increasingly, the rest of the world. Now off-the-shelf technology--Starlink terminals, plug-and-play nautical autopilots, high-resolution video cameras--may be advancing that cat-and-mouse game into a new phase. Uncrewed subs could move more cocaine over longer distances, and they wouldn't put human smugglers at risk of capture. And law enforcement around the world is just beginning to grapple with what this means for the future. This story is from the next print issue of magazine, which is all about crime. Google DeepMind is calling for the moral behavior of large language models--such as what they do when called on to act as companions, therapists, medical advisors, and so on--to be scrutinized with the same kind of rigor as their ability to code or do math.

Jean-Paul Thorbjornsen, an Australian man in his mid-30s, with a rural Catholic upbringing, is a founder of THORChain, a blockchain through which users can swap one cryptocurrency for another and earn fees from making those swaps. THORChain is permissionless, so anyone can use it without getting prior approval from a centralized authority. As a decentralized network, the blockchain is built and run by operators located across the globe. During its early days, Thorbjornsen himself hid behind the pseudonym "leena" and used an AI-generated female image as his avatar. But around March 2024, he revealed his true identity as the mind behind the blockchain. If there is a central question around THORChain, it is this: Exactly who is responsible for its operations?

Across the world, unsuspecting people are unwittingly becoming caught up in a new and growing type of organized criminal enterprise: vehicle transport fraud and theft. Crooks use email phishing, fraudulent paperwork, and other tactics to impersonate legitimate transport companies and get hired to deliver a luxury vehicle. They divert the shipment away from its intended destination before using a mix of technology, computer skills, and old-school techniques to erase traces of the vehicle's original ownership and registration. In some cases, the car has been resold or is out of the country by the time the rightful owner even realizes it's missing. The nationwide epidemic of vehicle transport fraud and theft has remained under the radar, even as it's rocked the industry over the past two years. Antimicrobial resistance is a major problem.

Hackers made death threats against this security researcher. In April 2024, a mysterious someone using the online handles "Waifu" and "Judische" began posting death threats on Telegram and Discord channels aimed at a cybersecurity researcher named Allison Nixon. These anonymous personas targeted Nixon because she had become a formidable threat: As chief research officer at the cyber investigations firm Unit 221B, named after Sherlock Holmes's apartment, she had built a career tracking cybercriminals and helping get them arrested. Though she'd done this work for more than a decade, Nixon couldn't understand why the person behind the accounts was suddenly threatening her. And although she had taken an interest in the Waifu persona in years past for crimes he boasted about committing, he hadn't been on her radar for a while when the threats began, because she was tracking other targets. Now Nixon resolved to unmask Waifu/Judische and others responsible for the death threats--and take them down for crimes they admitted to committing.

The Download: an exclusive chat with Jim O'Neill, and the surprising truth about heists Over the past year, Jim O'Neill has become one of the most powerful people in public health. As the US deputy health secretary, he holds two roles at the top of the country's federal health and science agencies. He oversees a department with a budget of over a trillion dollars. And he signed the decision memorandum on the US's deeply controversial new vaccine schedule. In an exclusive interview with earlier this month, O'Neill described his plans to increase human healthspan through longevity-focused research supported by ARPA-H, a federal agency dedicated to biomedical breakthroughs. Fellow longevity enthusiasts said they hope he will bring attention and funding to their cause.

Plus: Instagram's CEO Adam Mosseri has denied claims that social media is "clinically addictive" AI is already making online crimes easier. It could get much worse. Just as software engineers are using artificial intelligence to help write code and check for bugs, hackers are using these tools to reduce the time and effort required to orchestrate an attack, lowering the barriers for less experienced attackers to try something out. Some in Silicon Valley warn that AI is on the brink of being able to carry out fully automated attacks. But most security researchers instead argue that we should be paying closer attention to the much more immediate risks posed by AI, which is already speeding up and increasing the volume of scams. Criminals are increasingly exploiting the latest deepfake technologies to impersonate people and swindle victims out of vast sums of money.

Plus: social media firms have agreed to be assessed on how effectively they protect teens' mental health A "QuitGPT" campaign is urging people to cancel their ChatGPT subscriptions In September, Alfred Stephen, a freelance software developer in Singapore, purchased a ChatGPT Plus subscription, which costs $20 a month and offers more access to advanced models, to speed up his work. But he grew frustrated with the chatbot's coding abilities and its gushing, meandering replies. Then he came across a post on Reddit about a campaign called QuitGPT. QuitGPT is one of the latest salvos in a growing movement by activists and disaffected users to cancel their subscriptions. In just the past few weeks, users have flooded Reddit with stories about quitting the chatbot. And while it's unclear how many users have joined the boycott, there's no denying QuitGPT is getting attention.

Are you interested in learning more about the ways in which AI is being used? We've launched a new weekly newsletter series exploring just that: digging into how generative AI is being used and deployed across sectors and what professionals need to know to apply it in their everyday work. Each edition of Making AI Work begins with a case study, examining a specific use case of AI in a given industry. Then we'll take a deeper look at the AI tool being used, with more context about how other companies or sectors are employing that same tool or system. Finally, we'll end with action-oriented tips to help you apply the tool. The first edition takes a look at how AI is changing health care, digging into the future of medical note-taking by learning about the Microsoft Copilot tool used by doctors at Vanderbilt University Medical Center.

For a few days recently, the hottest new hangout on the internet was a vibe-coded Reddit clone called Moltbook, which billed itself as a social network for bots. As the website's tagline puts it: "Where AI agents share, discuss, and upvote. Launched on January 28, Moltbook went viral in a matter of hours. It's been designed as a place where instances of a free open-source LLM-powered agent known as OpenClaw (formerly known as ClawdBot, then Moltbot), could come together and do whatever they wanted. But is Moltbook really a glimpse of the future, as many have claimed? More than a billion people worldwide suffer from a mental-health condition, according to the World Health Organization. The prevalence of anxiety and depression is growing in many demographics, particularly young people, and suicide is claiming hundreds of thousands of lives globally each year. Given the clear demand for accessible and affordable mental-health services, it's no wonder that people have looked to artificial intelligence for possible relief. Millions are already actively seeking therapy from popular chatbots, or from specialized psychology apps like Wysa and Woebot. Four timely new books are a reminder that while the present feels like a blur of breakthroughs, scandals, and confusion, this disorienting time is rooted in deeper histories of care, technology, and trust. Making AI Work, MIT Technology Review's new AI newsletter, is here For years, our newsroom has explored AI's limitations and potential dangers, as well as its growing energy needs . And our reporters have looked closely at how generative tools are being used for tasks such as coding and running scientific experiments . But how is AI being used in fields like health care, climate tech, education, and finance? How are small businesses using it? And what should you keep in mind if you use AI tools at work? These questions guided the creation of Making AI Work, a new AI mini-course newsletter. Read more about it, and sign up here to receive the seven editions straight to your inbox. The number of civil lawsuits it's pursuing has sharply dropped in comparison to Trump's first term. It's the latest example of Brussels' attempts to rein in Big Tech. Local governments and banks are only too happy to oblige promising startups. Cryptocurrency is now fully part of the financial system, for better or worse. "Agentic engineering" is the next big thing, apparently. Runners had long suspected its suggestions were pushing them towards injury. Only around three dozen supporters turned up. Its menswear suggestions are more manosphere influencer than suave gentleman. "There is no Plan B, because that assumes you will fail.

Plus: Anthropic's new tools are freaking out the markets Every time OpenAI, Google, or Anthropic drops a new frontier large language model, the AI community holds its breath. It doesn't exhale until METR, an AI research nonprofit whose name stands for "Model Evaluation & Threat Research," updates a now-iconic graph that has played a major role in the AI discourse since it was first released in March of last year. The graph suggests that certain AI capabilities are developing at an exponential rate, and more recent model releases have outperformed that already impressive trend. That was certainly the case for Claude Opus 4.5, the latest version of Anthropic's most powerful model, which was released in late November. In December, METR announced that Opus 4.5 appeared to be capable of independently completing a task that would have taken a human about five hours--a vast improvement over what even the exponential trend would have predicted. But the truth is more complicated than those dramatic responses would suggest.