Pandemic defines the global outbreak of a disease having a high transmission rate. The impact of a pandemic situation can be lessened by restricting the movement of the mass. However, one of its concomitant circumstances is an economic crisis. In this article, we demonstrate what actions an agent (trained using reinforcement learning) may take in different possible scenarios of a pandemic depending on the spread of disease and economic factors. To train the agent, we design a virtual pandemic scenario closely related to the present COVID-19 crisis. Then, we apply reinforcement learning, a branch of artificial intelligence, that deals with how an individual (human/machine) should interact on an environment (real/virtual) to achieve the cherished goal. Finally, we demonstrate what optimal actions the agent perform to reduce the spread of disease while considering the economic factors. In our experiment, we let the agent find an optimal solution without providing any prior knowledge. After training, we observed that the agent places a long length lockdown to reduce the first surge of a disease. Furthermore, the agent places a combination of cyclic lockdowns and short length lockdowns to halt the resurgence of the disease. Analyzing the agent’s performed actions, we discover that the agent decides movement restrictions not only based on the number of the infectious population but also considering the reproduction rate of the disease. The estimation and policy of the agent may improve the human-strategy of placing lockdown so that an economic crisis may be avoided while mitigating an infectious disease.

There has been a current trend in reinforcement learning for healthcare literature, where in order to prepare clinical datasets, researchers will carry forward the last results of the non-administered test known as the last-observation-carried-forward (LOCF) value to fill in gaps, assuming that it is still an accurate indicator of the patient's current state. These values are carried forward without maintaining information about exactly how these values were imputed, leading to ambiguity. Our approach models this problem using OpenAI Gym's Mountain Car and aims to address when to observe the patient's physiological state and partly how to intervene, as we have assumed we can only act after following an observation. So far, we have found that for a last-observation-carried-forward implementation of the state space, augmenting the state with counters for each state variable tracking the time since last observation was made, improves the predictive performance of an agent, supporting the notion of "informative missingness", and using a neural network based Dynamics Model to predict the most probable next state value of non-observed state variables instead of carrying forward the last observed value through LOCF further improves the agent's performance, leading to faster convergence and reduced variance.