The roundworm C. elegans exhibits robust escape behavior in response to rapidly rising temperature. The behavior lasts for a few seconds, shows history dependence, involves both sensory and motor systems, and is too complicated to model mechanistically using currently available knowledge. Instead we model the process phenomenologically, and we use the Sir Isaac dynamical inference platform to infer the model in a fully automated fashion directly from experimental data. The inferred model requires incorporation of an unobserved dynamical variable, and is biologically interpretable. The model makes accurate predictions about the dynamics of the worm behavior, and it can be used to characterize the functional logic of the dynamical system underlying the escape response. This work illustrates the power of modern artificial intelligence to aid in discovery of accurate and interpretable models of complex natural systems.

Statistical evolutionary models provide an important mechanism for describing and understanding the escape response of a viral population under a particular therapy. We present a new hierarchical model that incorporates spatially varying mutation and recombination rates at the nucleotide level. It also maintains sep- arate parameters for treatment and control groups, which allows us to estimate treatment effects explicitly. We use the model to investigate the sequence evolu- tion of HIV populations exposed to a recently developed antisense gene therapy, as well as a more conventional drug therapy. The detection of biologically rele- vant and plausible signals in both therapy studies demonstrates the effectiveness of the method.

In response to a puff of wind, the American cockroach turns away and runs. The circuit underlying the initial turn of this escape response consists of three populations of individually identifiable nerve cells and appears to employ distributed representations in its operation. We have reconstructed several neuronal and behavioral properties of this system using simplified neural network models and the backpropagation learning algorithm constrained by known structural characteristics of the circuitry. In order to test and refine the model, we have also compared the model's responses to various lesions with the insect's responses to similar lesions.

In response to a puff of wind, the American cockroach turns away and runs. The circuit underlying the initial turn of this escape response consists of three populations of individually identifiable nerve cells and appears to employ distributed representations in its operation. We have reconstructed several neuronal and behavioral properties of this system using simplified neural network models and the backpropagation learning algorithm constrained by known structural characteristics of the circuitry. In order to test and refine the model, we have also compared the model's responses to various lesions with the insect's responses to similar lesions.

In response to a puff of wind, the American cockroach turns away and runs. The circuit underlying the initial turn of this escape response consists of three populations of individually identifiable nerve cells and appears to employ distributedrepresentations in its operation. We have reconstructed several neuronal and behavioral properties of this system using simplified neural network models and the backpropagation learning algorithm constrained byknown structural characteristics of the circuitry. In order to test and refine the model, we have also compared the model's responses to various lesions with the insect's responses to similar lesions.