Clinical trials are a systematic endeavor to assess the safety and efficacy of new drugs or treatments. Conducting such trials typically demands significant financial investment and meticulous planning, highlighting the need for accurate predictions of trial outcomes. Accurately predicting patient enrollment, a key factor in trial success, is one of the primary challenges during the planning phase. In this work, we propose a novel deep learning-based method to address this critical challenge. Our method, implemented as a neural network model, leverages pre-trained language models (PLMs) to capture the complexities and nuances of clinical documents, transforming them into expressive representations. These representations are then combined with encoded tabular features via an attention mechanism. To account for uncertainties in enrollment prediction, we enhance the model with a probabilistic layer based on the Gamma distribution, which enables range estimation. We apply the proposed model to predict clinical trial duration, assuming site-level enrollment follows a Poisson-Gamma process. We carry out extensive experiments on real-world clinical trial data, and show that the proposed method can effectively predict the number of patients enrolled at a number of sites for a given clinical trial, outperforming established baseline models.

Enrollment projection is a critical aspect of university management, guiding decisions related to resource allocation and revenue forecasting. However, despite its importance, there remains a lack of transparency regarding the methodologies utilized by many institutions. This paper presents an innovative approach to enrollment projection using Markov Chain modeling, drawing upon a case study conducted at Eastern Michigan University (EMU). Markov Chain modeling emerges as a promising approach for enrollment projection, offering precise predictions based on historical trends. This paper outlines the implementation of Enhanced Markov Chain modeling at EMU, detailing the methodology used to compute transition probabilities and evaluate model performance. Despite challenges posed by external uncertainties such as the COVID-19 pandemic, Markov Chain modeling has demonstrated impressive accuracy, with an average difference of less than 1 percent between predicted and actual enrollments. The paper concludes with a discussion of future directions and opportunities for collaboration among institutions.