Several problems such as network intrusion, community detection, and disease outbreak can be described by observations attributed to nodes or edges of a graph. In these applications presence of intrusion, community or disease outbreak is characterized by novel observations on some unknown connected subgraph. These problems can be formulated in terms of optimization of suitable objectives on connected subgraphs, a problem which is generally computationally difficult. We overcome the combinatorics of connectivity by embedding connected subgraphs into linear matrix inequalities (LMI). Computationally efficient tests are then realized by optimizing convex objective functions subject to these LMI constraints. We prove, by means of a novel Euclidean embedding argument, that our tests are minimax optimal for exponential family of distributions on 1-D and 2-D lattices. We show that internal conductance of the connected subgraph family plays a fundamental role in characterizing detectability.

The rapid evolution of artificial intelligence (AI), together with the increased availability of social media and news for epidemiological surveillance, are marking a pivotal moment in epidemiology and public health research. Leveraging the power of generative AI, we use an ensemble approach which incorporates multiple Large Language Models (LLMs) to extract valuable actionable epidemiological information from the World Health Organization (WHO) Disease Outbreak News (DONs). DONs is a collection of regular reports on global outbreaks curated by the WHO and the adopted decision-making processes to respond to them. The extracted information is made available in a daily-updated dataset and a knowledge graph, referred to as eKG, derived to provide a nuanced representation of the public health domain knowledge. We provide an overview of this new dataset and describe the structure of eKG, along with the services and tools used to access and utilize the data that we are building on top. These innovative data resources open altogether new opportunities for epidemiological research, and the analysis and surveillance of disease outbreaks.

Wheat yellow rust, caused by the fungus Puccinia striiformis, is a critical disease affecting wheat crops across Britain, leading to significant yield losses and economic consequences. Given the rapid environmental changes and the evolving virulence of pathogens, there is a growing need for innovative approaches to predict and manage such diseases over the long term. This study explores the feasibility of using deep learning models to predict outbreaks of wheat yellow rust in British fields, offering a proactive approach to disease management. We construct a yellow rust dataset with historial weather information and disease indicator acrossing multiple regions in England. We employ two poweful deep learning models, including fully connected neural networks and long short-term memory to develop predictive models capable of recognizing patterns and predicting future disease outbreaks.The models are trained and validated in a randomly sliced datasets. The performance of these models with different predictive time steps are evaluated based on their accuracy, precision, recall, and F1-score. Preliminary results indicate that deep learning models can effectively capture the complex interactions between multiple factors influencing disease dynamics, demonstrating a promising capacity to forecast wheat yellow rust with considerable accuracy. Specifically, the fully-connected neural network achieved 83.65% accuracy in a disease prediction task with 6 month predictive time step setup. These findings highlight the potential of deep learning to transform disease management strategies, enabling earlier and more precise interventions. Our study provides a methodological framework for employing deep learning in agricultural settings but also opens avenues for future research to enhance the robustness and applicability of predictive models in combating crop diseases globally.

Early Warning Signals (EWSs) are vital for implementing preventive measures before a disease turns into a pandemic. While new diseases exhibit unique behaviors, they often share fundamental characteristics from a dynamical systems perspective. Moreover, measurements during disease outbreaks are often corrupted by different noise sources, posing challenges for Time Series Classification (TSC) tasks. In this study, we address the problem of having a robust EWS for disease outbreak prediction using a best-performing deep learning model in the domain of TSC. We employed two simulated datasets to train the model: one representing generated dynamical systems with randomly selected polynomial terms to model new disease behaviors, and another simulating noise-induced disease dynamics to account for noisy measurements. The model's performance was analyzed using both simulated data from different disease models and real-world data, including influenza and COVID-19. Results demonstrate that the proposed model outperforms previous models, effectively providing EWSs of impending outbreaks across various scenarios. This study bridges advancements in deep learning with the ability to provide robust early warning signals in noisy environments, making it highly applicable to real-world crises involving emerging disease outbreaks.

Objectives: Our research adopts computational techniques to analyze disease outbreaks weekly over a large geographic area while maintaining local-level analysis by incorporating relevant high-spatial resolution cultural and environmental datasets. The abundance of data about disease outbreaks gives scientists an excellent opportunity to uncover patterns in disease spread and make future predictions. However, data over a sizeable geographic area quickly outpace human cognition. Our study area covers a significant portion of the African continent (about 17,885,000 km2). The data size makes computational analysis vital to assist human decision-makers. Methods: We first applied global and local spatial autocorrelation for malaria, cholera, meningitis, and yellow fever case counts. We then used machine learning to predict the weekly presence of these diseases in the second-level administrative district. Lastly, we used machine learning feature importance methods on the variables that affect spread. Results: Our spatial autocorrelation results show that geographic nearness is critical but varies in effect and space. Moreover, we identified many interesting hot and cold spots and spatial outliers. The machine learning model infers a binary class of cases or none with the best F1 score of 0.96 for malaria. Machine learning feature importance uncovered critical cultural and environmental factors affecting outbreaks and variations between diseases. Conclusions: Our study shows that data analytics and machine learning are vital to understanding and monitoring disease outbreaks locally across vast areas. The speed at which these methods produce insights can be critical during epidemics and emergencies.

Many uncontrollable disease outbreaks of the past exposed several vulnerabilities in the healthcare systems worldwide. While advancements in technology assisted in the rapid creation of the vaccinations, there needs to be a pressing focus on the prevention and prediction of such massive outbreaks. Early detection and intervention of an outbreak can drastically reduce its impact on public health while also making the healthcare system more resilient. The complexity of disease transmission dynamics, influence of various directly and indirectly related factors and limitations of traditional approaches are the main bottlenecks in taking preventive actions. Specifically, this paper implements deep learning algorithms and LLM's to predict the severity of infectious disease outbreaks. Utilizing the historic data of several diseases that have spread in India and the climatic data spanning the past decade, the insights from our research aim to assist in creating a robust predictive system for any outbreaks in the future.

Forecasting the occurrence and absence of novel disease outbreaks is essential for disease management. Here, we develop a general model, with no real-world training data, that accurately forecasts outbreaks and non-outbreaks. We propose a novel framework, using a feature-based time series classification method to forecast outbreaks and non-outbreaks. We tested our methods on synthetic data from a Susceptible-Infected-Recovered model for slowly changing, noisy disease dynamics. Outbreak sequences give a transcritical bifurcation within a specified future time window, whereas non-outbreak (null bifurcation) sequences do not. We identified incipient differences in time series of infectives leading to future outbreaks and non-outbreaks. These differences are reflected in 22 statistical features and 5 early warning signal indicators. Classifier performance, given by the area under the receiver-operating curve, ranged from 0.99 for large expanding windows of training data to 0.7 for small rolling windows. Real-world performances of classifiers were tested on two empirical datasets, COVID-19 data from Singapore and SARS data from Hong Kong, with two classifiers exhibiting high accuracy. In summary, we showed that there are statistical features that distinguish outbreak and non-outbreak sequences long before outbreaks occur. We could detect these differences in synthetic and real-world data sets, well before potential outbreaks occur.

The timely detection of disease outbreaks through reliable early warning signals (EWSs) is indispensable for effective public health mitigation strategies. Nevertheless, the intricate dynamics of real-world disease spread, often influenced by diverse sources of noise and limited data in the early stages of outbreaks, pose a significant challenge in developing reliable EWSs, as the performance of existing indicators varies with extrinsic and intrinsic noises. Here, we address the challenge of modeling disease when the measurements are corrupted by additive white noise, multiplicative environmental noise, and demographic noise into a standard epidemic mathematical model. To navigate the complexities introduced by these noise sources, we employ a deep learning algorithm that provides EWS in infectious disease outbreak by training on noise-induced disease-spreading models. The indicator's effectiveness is demonstrated through its application to real-world COVID-19 cases in Edmonton and simulated time series derived from diverse disease spread models affected by noise. Notably, the indicator captures an impending transition in a time series of disease outbreaks and outperforms existing indicators. This study contributes to advancing early warning capabilities by addressing the intricate dynamics inherent in real-world disease spread, presenting a promising avenue for enhancing public health preparedness and response efforts.

This seems the only suitable word to assess the huge amount of data being generated due to the ensuing COVID 19 pandemic and the global lockdown caused by it. We can broadly classify the data into two categories – Deliberate and Non-Deliberate. The first category of the data is being generated by governments as part of their response plan to the pandemic while the second category of data is being automatically generated due to the global lockdown. As the governments have well-defined objectives to create and use the data they are generating to control the outbreak of COVID 19 in their respective territories, this category of data is immediately being used in their outbreak response plans such as communication campaigns, diseases prevention, social distancing, awareness campaigns, diagnosis, prognosis, and treatment with the help of AI (Artificial Intelligence) based technological innovations particularly mobile apps, dashboard, websites, etc. In addition to the urgent disease containment plans, the first category of data will also be crucial for assessing health systems, developing pandemic/epidemic/outbreak resilience plans and assessing economic impacts to improve future resilience. However, the collection and use of the second category of data is likely to guide the national and global policies for the years from transport planning, supply chain management, global warming, carbon emission, climate change, biodiversity, regional cooperation, geopolitics and much more.

Join us on November 9 to learn how to successfully innovate and achieve efficiency by upskilling and scaling citizen developers at the Low-Code/No-Code Summit. From COVID--19 to monkeypox and intermittent polio scares, concerns around public health crises have significantly increased over the past several years. Living in a globally connected world amidst climate change and a growing population has enabled the emergence of more frequent viruses and fostered their spread. A research study last year estimated that the probability of novel disease outbreaks will grow three-fold in the next few decades. Fortunately, there have been significant technological developments that can help minimize the impact of these global health issues.