direct prediction
e0af79ad53a336b4c4b4f7e2a68eb609-Paper-Conference.pdf
Humans have a powerful and mysterious capacity to reason. Working through a set of mental steps enables us to make inferences we would not be capable of making directly even though we get no additional data from the world. Similarly, when large language models generate intermediate steps (a chain of thought) before answering a question, they often produce better answers than they would directly. We investigate why and how chain-of-thought reasoning is useful in language models, testing the hypothesis that reasoning is effective when training data consists of overlapping local clusters of variables that influence each other strongly. These training conditions enable the chaining of accurate local inferences to estimate relationships between variables that were not seen together in training.
Chain of Time: In-Context Physical Simulation with Image Generation Models
Wang, YingQiao, Bigelow, Eric, Li, Boyi, Ullman, Tomer
We propose a novel cognitively-inspired method to improve and interpret physical simulation in vision-language models. Our ``Chain of Time" method involves generating a series of intermediate images during a simulation, and it is motivated by in-context reasoning in machine learning, as well as mental simulation in humans. Chain of Time is used at inference time, and requires no additional fine-tuning. We apply the Chain-of-Time method to synthetic and real-world domains, including 2-D graphics simulations and natural 3-D videos. These domains test a variety of particular physical properties, including velocity, acceleration, fluid dynamics, and conservation of momentum. We found that using Chain-of-Time simulation substantially improves the performance of a state-of-the-art image generation model. Beyond examining performance, we also analyzed the specific states of the world simulated by an image model at each time step, which sheds light on the dynamics underlying these simulations. This analysis reveals insights that are hidden from traditional evaluations of physical reasoning, including cases where an image generation model is able to simulate physical properties that unfold over time, such as velocity, gravity, and collisions. Our analysis also highlights particular cases where the image generation model struggles to infer particular physical parameters from input images, despite being capable of simulating relevant physical processes.
PRISM2: Unlocking Multi-Modal General Pathology AI with Clinical Dialogue
Vorontsov, Eugene, Shaikovski, George, Casson, Adam, Viret, Julian, Zimmermann, Eric, Tenenholtz, Neil, Wang, Yi Kan, Bernhard, Jan H., Godrich, Ran A., Retamero, Juan A., Shia, Jinru, Gonen, Mithat, Weiser, Martin R., Klimstra, David S., Yousfi, Razik, Fusi, Nicolo, Fuchs, Thomas J., Severson, Kristen, Liu, Siqi
Recent rapid progress in the field of computational pathology has been enabled by foundation models. These models are beginning to move beyond encoding image patches towards whole-slide understanding but their clinical utility remains limited. In this work, we present PRISM2, a multimodal slide-level foundation model trained on data from 700,000 diagnostic specimen-report pairs, the largest vision (2.3 million whole slide images) and language (14M question-answer pairs) histopathology dataset to date. By learning through clinical-dialogue supervision, PRISM2 aligns histomorphologic features with the language of diagnostic reasoning, producing slide-level representations that support both direct diagnostic question-answering and transferable embeddings for downstream tasks. Without additional training, PRISM2 matches or exceeds the cancer-detection performance of clinical-grade products. This is observed without loss of generality on other tasks, where PRISM2 achieves top performance. Finally, using survival prediction as the example, we show that task-specific finetuning with a large dataset can outperform task-specific models, further improving performance. These results demonstrate how language-supervised pretraining provides a scalable, clinically grounded signal for learning generalizable pathology representations, bridging human diagnostic reasoning and foundation-model performance.
Evaluating LLMs on Real-World Forecasting Against Expert Forecasters
Large language models (LLMs) have demonstrated remarkable capabilities across diverse tasks, but their ability to forecast future events remains understudied. A year ago, large language models struggle to come close to the accuracy of a human crowd. I evaluate state-of-the-art LLMs on 464 forecasting questions from Metaculus, comparing their performance against top forecasters. Frontier models achieve Brier scores that ostensibly surpass the human crowd but still significantly underperform a group of experts.
Learning the action for long-time-step simulations of molecular dynamics
Bigi, Filippo, Ceriotti, Michele
Laboratory of Computational Science and Modeling, Institut des Mat eriaux, Ecole Polytechnique F ed erale de Lausanne, 1015 Lausanne, Switzerland (Dated: August 5, 2025) The equations of classical mechanics can be used to model the time evolution of countless physical systems, from the astrophysical to the atomic scale. Accurate numerical integration requires small time steps, which limits the computational efficiency - especially in cases such as molecular dynamics that span wildly different time scales. Using machine-learning (ML) algorithms to predict trajectories allows one to greatly extend the integration time step, at the cost of introducing artifacts such as lack of energy conservation and loss of equipartition between different degrees of freedom of a system. We propose learning data-driven structure-preserving (symplectic and time-reversible) maps to generate long-time-step classical dynamics, showing that this method is equivalent to learning the mechanical action of the system of interest. We show that an action-derived ML integrator eliminates the pathological behavior of non-structure-preserving ML predictors, and that the method can be applied iteratively, serving as a correction to computationally cheaper direct predictors. Simulating classical mechanical systems with high accuracy and efficiency is a long-standing challenge in computational physics [31, 32]. Traditional numerical methods typically rely on small time steps to propagate the equations of motion for the dynamical system in order to provide accurate integration.
Improve Vision Language Model Chain-of-thought Reasoning
Zhang, Ruohong, Zhang, Bowen, Li, Yanghao, Zhang, Haotian, Sun, Zhiqing, Gan, Zhe, Yang, Yinfei, Pang, Ruoming, Yang, Yiming
Chain-of-thought (CoT) reasoning in vision language models (VLMs) is crucial for improving interpretability and trustworthiness. However, current training recipes lack robust CoT reasoning data, relying on datasets dominated by short annotations with minimal rationales. In this work, we show that training VLM on short answers does not generalize well to reasoning tasks that require more detailed responses. To address this, we propose a two-fold approach. First, we distill rationales from GPT-4o model to enrich the training data and fine-tune VLMs, boosting their CoT performance. Second, we apply reinforcement learning to further calibrate reasoning quality. Specifically, we construct positive (correct) and negative (incorrect) pairs of model-generated reasoning chains, by comparing their predictions with annotated short answers. Using this pairwise data, we apply the Direct Preference Optimization algorithm to refine the model's reasoning abilities. Our experiments demonstrate significant improvements in CoT reasoning on benchmark datasets and better generalization to direct answer prediction as well. This work emphasizes the importance of incorporating detailed rationales in training and leveraging reinforcement learning to strengthen the reasoning capabilities of VLMs.
Why think step by step? Reasoning emerges from the locality of experience
Prystawski, Ben, Li, Michael Y., Goodman, Noah D.
Humans have a powerful and mysterious capacity to reason. Working through a set of mental steps enables us to make inferences we would not be capable of making directly even though we get no additional data from the world. Similarly, when large language models generate intermediate steps (a chain of thought) before answering a question, they often produce better answers than they would directly. We investigate why and how chain-of-thought reasoning is useful in language models, testing the hypothesis that reasoning is effective when training data consists of overlapping local clusters of variables that influence each other strongly. These training conditions enable the chaining of accurate local inferences to estimate relationships between variables that were not seen together in training. We prove that there will exist a "reasoning gap", where reasoning through intermediate variables reduces bias, for the simple case of an autoregressive density estimator trained on local samples from a chain-structured probabilistic model. We then test our hypothesis experimentally in more complex models, training an autoregressive language model on samples from Bayes nets but only including a subset of variables in each sample. We test language models' ability to match conditional probabilities with and without intermediate reasoning steps, finding that intermediate steps are only helpful when the training data is locally structured with respect to dependencies between variables. The combination of locally structured observations and reasoning is much more data-efficient than training on all variables. Our results illustrate how the effectiveness of reasoning step by step is rooted in the local statistical structure of the training data.