Prefix adders are widely used in compute-intensive applications for their high speed. However, designing optimized prefix adders is challenging due to strict design rules and an exponentially large design space. We introduce PrefixGPT, a generative pre-trained Transformer (GPT) that directly generates optimized prefix adders from scratch. Our approach represents an adder's topology as a two-dimensional coordinate sequence and applies a legality mask during generation, ensuring every design is valid by construction. PrefixGPT features a customized decoder-only Transformer architecture. The model is first pre-trained on a corpus of randomly synthesized valid prefix adders to learn design rules and then fine-tuned to navigate the design space for optimized design quality. Compared with existing works, PrefixGPT not only finds a new optimal design with a 7.7% improved area-delay product (ADP) but exhibits superior exploration quality, lowering the average ADP by up to 79.1%. This demonstrates the potential of GPT -style models to first master complex hardware design principles and then apply them for more efficient design optimization.

--Recent advancements in layout pattern generation have been dominated by deep generative models. However, relying solely on neural networks for legality guarantees raises concerns in many practical applications. In this paper, we present DiffPattern-Flex, a novel approach designed to generate reliable layout patterns efficiently. DiffPattern-Flex incorporates a new method for generating diverse topologies using a discrete diffusion model while maintaining a lossless and compute-efficient layout representation. T o ensure legal pattern generation, we employ an optimization-based, white-box pattern assessment process based on specific design rules. Furthermore, fast sampling and efficient legalization technologies are employed to accelerate the generation process. Experimental results across various benchmarks demonstrate that DiffPattern-Flex significantly outperforms existing methods and excels at producing reliable layout patterns. ELIABLE very-large-scale integration (VLSI) layout pattern libraries form the backbone of various Design for Manufacturability (DFM) research, such as refining design rules [1]-[3], optimizing Optical Proximity Correction (OPC) techniques [4]-[6], performing lithography simulations [7]-[9], and detecting layout hotspots [10]-[12]. With the increasing demand for layout patterns in machine-learning-based lithography design, building a comprehensive and practical large-scale pattern library has become highly resource-intensive due to the extended logic-to-chip design cycle. To address this challenge, a variety of rule-based and learning-based layout pattern generation methods have been introduced. These units were then randomly selected and combined. However, this approach results in limited diversity and quantity of generated patterns. More recently, learning-based generative methods [15]-[19] have demonstrated the ability to produce diverse layout patterns at a larger scale. This work is supported by The Research Grants Council of Hong Kong SAR (No. CUHK14208021) and the MIND project (MINDXZ202404). Y unheng Shen is with Tsinghua University, Beijing, China.

Flexibility in the AI-based residential layout design remains a significant challenge, as traditional methods like rule-based heuristics and graph-based generation often lack flexibility and require substantial design knowledge from users. To address these limitations, we propose a cross-modal design approach based on the Stable Diffusion model for generating flexible residential layouts. The method offers multiple input types for learning objectives, allowing users to specify both boundaries and layouts. It incorporates natural language as design constraints and introduces ControlNet to enable stable layout generation through two distinct pathways. We also present a scheme that encapsulates design expertise within a knowledge graph and translates it into natural language, providing an interpretable representation of design knowledge. This comprehensibility and diversity of input options enable professionals and non-professionals to directly express design requirements, enhancing flexibility and controllability. Finally, experiments verify the flexibility of the proposed methods under multimodal constraints better than state-of-the-art models, even when specific semantic information about room areas or connections is incomplete.

Computer-aided design (CAD) tools empower designers to design and modify 3D models through a series of CAD operations, commonly referred to as a CAD sequence. In scenarios where digital CAD files are not accessible, reverse engineering (RE) has been used to reconstruct 3D CAD models. Recent advances have seen the rise of data-driven approaches for RE, with a primary focus on converting 3D data, such as point clouds, into 3D models in boundary representation (B-rep) format. However, obtaining 3D data poses significant challenges, and B-rep models do not reveal knowledge about the 3D modeling process of designs. To this end, our research introduces a novel data-driven approach with an Image2CADSeq neural network model. This model aims to reverse engineer CAD models by processing images as input and generating CAD sequences. These sequences can then be translated into B-rep models using a solid modeling kernel. Unlike B-rep models, CAD sequences offer enhanced flexibility to modify individual steps of model creation, providing a deeper understanding of the construction process of CAD models. To quantitatively and rigorously evaluate the predictive performance of the Image2CADSeq model, we have developed a multi-level evaluation framework for model assessment. The model was trained on a specially synthesized dataset, and various network architectures were explored to optimize the performance. The experimental and validation results show great potential for the model in generating CAD sequences from 2D image data.

In the advanced technology nodes, the integrated design rule checker (DRC) is often utilized in place and route tools for fast optimization loops for power-performance-area. Implementing integrated DRC checkers to meet the standard of commercial DRC tools demands extensive human expertise to interpret foundry specifications, analyze layouts, and debug code iteratively. However, this labor-intensive process, requiring to be repeated by every update of technology nodes, prolongs the turnaround time of designing circuits. In this paper, we present DRC-Coder, a multi-agent framework with vision capabilities for automated DRC code generation. By incorporating vision language models and large language models (LLM), DRC-Coder can effectively process textual, visual, and layout information to perform rule interpretation and coding by two specialized LLMs. We also design an auto-evaluation function for LLMs to enable DRC code debugging. Experimental results show that targeting on a sub-3nm technology node for a state-of-the-art standard cell layout tool, DRC-Coder achieves perfect F1 score 1.000 in generating DRC codes for meeting the standard of a commercial DRC tool, highly outperforming standard prompting techniques (F1=0.631). DRC-Coder can generate code for each design rule within four minutes on average, which significantly accelerates technology advancement and reduces engineering costs.

Existing works focus on fixed-size layout pattern generation, while the more practical free-size pattern generation receives limited attention. In this paper, we propose ChatPattern, a novel Large-Language-Model (LLM) powered framework for flexible pattern customization. ChatPattern utilizes a two-part system featuring an expert LLM agent and a highly controllable layout pattern generator. The LLM agent can interpret natural language requirements and operate design tools to meet specified needs, while the generator excels in conditional layout generation, pattern modification, and memory-friendly patterns extension. Experiments on challenging pattern generation setting shows the ability of ChatPattern to synthesize high-quality large-scale patterns.

We propose a context-sensitive grammar for the systematic exploration of the design space of the topology of 3D robots, particularly unmanned aerial vehicles. It defines production rules for adding components to an incomplete design topology modeled over a 3D grid. The rules are local. The grammar is simple, yet capable of modeling most existing UAVs as well as novel ones. It can be easily generalized to other robotic platforms. It can be thought of as a building block for any design exploration and optimization algorithm.

This work harnesses interpretable machine learning methods to address the challenging inverse design problem of origami-inspired systems. We show that a decision tree-random forest method is particularly suitable for fitting origami databases, containing both design features and functional performance, to generate human-understandable decision rules for the inverse design of functional origami. First, the tree method is unique because it can handle complex interactions between categorical features and continuous features, allowing it to compare different origami patterns for a design. Second, this interpretable method can tackle multi-objective problems for designing functional origami with multiple and multi-physical performance targets. Finally, the method can extend existing shape-fitting algorithms for origami to consider non-geometrical performance. The proposed framework enables holistic inverse design of origami, considering both shape and function, to build novel reconfigurable structures for various applications such as metamaterials, deployable structures, soft robots, biomedical devices, and many more.

Subtle variations in the lipid composition of mitochondrial membranes can have a profound impact on mitochondrial function. The inner mitochondrial membrane contains the phospholipid cardiolipin, which has been demonstrated to act as a biomarker for a number of diverse pathologies. Small molecule dyes capable to selectively partitioning into cardiolipin membranes enable visualization and quantification of the cardiolipin content. Here we present a data-driven approach that combines a deep learning-enabled active learning workflow with coarse-grained molecular dynamics simulations and alchemical free energy calculations to discover small organic compounds able to selectively permeate cardiolipin-containing membranes. By employing transferable coarse-grained models we efficiently navigate the all-atom design space corresponding to small organic molecules with molecular weight less than 500 Da.

A team lead by researchers in the Pritzker School of Molecular Engineering (PME) at the University of Chicago reports that it has developed an artificial intelligence-led process that uses big data to design new proteins that could have implications across the healthcare, agriculture, and energy sectors. By developing machine-learning models that can review protein information culled from genome databases, the scientists say they found relatively simple design rules for building artificial proteins. When the team constructed these artificial proteins in the lab, they discovered that they performed chemistries so well that they rivaled those found in nature. "We have all wondered how a simple process like evolution can lead to such a high-performance material as a protein," said Rama Ranganathan, PhD, Joseph Regenstein Professor in the Department of Biochemistry and Molecular Biology, Pritzker Molecular Engineering, and the College. "We found that genome data contains enormous amounts of information about the basic rules of protein structure and function, and now we've been able to bottle nature's rules to create proteins ourselves."