Graft-versus-host disease (GVHD) is a rare but often fatal complication in liver transplantation, with a very high mortality rate. By harnessing multi-modal deep learning methods to integrate heterogeneous and imbalanced electronic health records (EHR), we aim to advance early prediction of GVHD, paving the way for timely intervention and improved patient outcomes. In this study, we analyzed pre-transplant electronic health records (EHR) spanning the period before surgery for 2,100 liver transplantation patients, including 42 cases of graft-versus-host disease (GVHD), from a cohort treated at Mayo Clinic between 1992 and 2025. The dataset comprised four major modalities: patient demographics, laboratory tests, diagnoses, and medications. We developed a multi-modal deep learning framework that dynamically fuses these modalities, handles irregular records with missing values, and addresses extreme class imbalance through AUC-based optimization. The developed framework outperforms all single-modal and multi-modal machine learning baselines, achieving an AUC of 0.836, an AUPRC of 0.157, a recall of 0.768, and a specificity of 0.803. It also demonstrates the effectiveness of our approach in capturing complementary information from different modalities, leading to improved performance. Our multi-modal deep learning framework substantially improves existing approaches for early GVHD prediction. By effectively addressing the challenges of heterogeneity and extreme class imbalance in real-world EHR, it achieves accurate early prediction. Our proposed multi-modal deep learning method demonstrates promising results for early prediction of a GVHD in liver transplantation, despite the challenge of extremely imbalanced EHR data.

Predicting the virality of online content remains challenging, especially for culturally complex, fast-evolving memes. This study investigates the feasibility of early prediction of meme virality using a large-scale, cross-lingual dataset from 25 diverse Reddit communities. We propose a robust, data-driven method to define virality based on a hybrid engagement score, learning a percentile-based threshold from a chronologically held-out training set to prevent data leakage. We evaluated a suite of models, including Logistic Regression, XGBoost, and a Multi-layer Perceptron (MLP), with a comprehensive, multimodal feature set across increasing time windows (30-420 min). Crucially, useful signals emerge quickly: our best-performing model, XGBoost, achieves a PR-AUC $>$ 0.52 in just 30 minutes. Our analysis reveals a clear "evidentiary transition," in which the importance of the feature dynamically shifts from the static context to the temporal dynamics as a meme gains traction. This work establishes a robust, interpretable, and practical benchmark for early virality prediction in scenarios where full diffusion cascade data is unavailable, contributing a novel cross-lingual dataset and a methodologically sound definition of virality. To our knowledge, this study is the first to combine time series data with static content and network features to predict early meme virality.

Patient stratification--identifying clinically meaningful subgroups--is essential for advancing personalized medicine through improved diagnostics and treatment strategies. Electronic health records (EHRs), particularly those from intensive care units (ICUs), contain rich temporal clinical data that can be leveraged for this purpose. In this work, we introduce ICU-TSB (Temporal Stratification Benchmark), the first comprehensive benchmark for evaluating patient stratification based on temporal patient representation learning using three publicly available ICU EHR datasets. A key contribution of our benchmark is a novel hierarchical evaluation framework utilizing disease taxonomies to measure the alignment of discovered clusters with clinically validated disease groupings. In our experiments with ICU-TSB, we compared statistical methods and several recurrent neural networks, including LSTM and GRU, for their ability to generate effective patient representations for subsequent clustering of patient trajectories. Our results demonstrate that temporal representation learning can rediscover clinically meaningful patient cohorts; nevertheless, it remains a challenging task, with v-measuring varying from up to 0.46 at the top level of the taxonomy to up to 0.40 at the lowest level. To further enhance the practical utility of our findings, we also evaluate multiple strategies for assigning interpretable labels to the identified clusters.

Flash is a collection of tasks for fast prototyping, baselining and fine-tuning scalable Deep Learning models, built on PyTorch Lightning. Whether you are new to deep learning, or an experienced researcher, Flash offers a seamless experience from baseline experiments to state-of-the-art research. It allows you to build models without being overwhelmed by all the details, and then seamlessly override and experiment with Lightning for full flexibility. Continue reading to learn how to use Flash tasks to get state-of-the-art results in a flash. Over the past year, PyTorch Lightning has received an enthusiastic response from the community for decoupling research from boilerplate code, enabling seamless distributed training, logging, and reproducibility of deep learning research code.