The growth of myriad cyber-threats continues to accelerate, yet the stream of new and effective cyber-defense technologies has grown much more slowly. The gap between threat and defense has widened, as our adversaries deploy increasingly sophisticated attack technology and engage in cyber-crime with unprecedented power, resources, and global reach. We are in an escalating asymmetric cyber environment that calls for immediate action. The extension of cyber-attacks into the socio-techno realm and the use of cyber as an information influence and disinformation vector will continue to undermine our confidence in systems. The unknown is a growing threat in our cyber information systems.