The recent developments of adiabatic quantum machine learning (AQML) methods and applications based on the quadratic unconstrained binary optimization (QUBO) model have received attention from academics and practitioners. Traditional machine learning methods such as support vector machines, balanced k-means clustering, linear regression, Decision Tree Splitting, Restricted Boltzmann Machines, and Deep Belief Networks can be transformed into a QUBO model. The training of adiabatic quantum machine learning models is the bottleneck for computation. Heuristics-based quantum annealing solvers such as Simulated Annealing and Multiple Start Tabu Search (MSTS) are implemented to speed up the training of AQML based on the QUBO model. The main purpose of this paper is to present a hybrid heuristic embedding an r-flip strategy to solve large-scale QUBO with an improved solution and shorter computing time compared to the state-of-the-art MSTS method. The results of the substantial computational experiments are reported to compare an r-flip strategy embedded hybrid heuristic and a multiple start tabu search algorithm on a set of benchmark instances and three large-scale QUBO instances. The r-flip strategy embedded algorithm provides very high-quality solutions within the CPU time limits of 60 and 600 seconds.

In this work, the online printing shop scheduling problem introduced in (Lunardi et al., Mixed Integer Linear Programming and Constraint Programming Models for the Online Printing Shop Scheduling Problem, Computers & Operations Research, to appear) is considered. This challenging real scheduling problem, that emerged in the nowadays printing industry, corresponds to a flexible job shop scheduling problem with sequencing flexibility; and it presents several complicating specificities such as resumable operations, periods of unavailability of the machines, sequence-dependent setup times, partial overlapping between operations with precedence constraints, and fixed operations, among others. A local search strategy and metaheuristic approaches for the problem are proposed and evaluated. Based on a common representation scheme, trajectory and populational metaheuristics are considered. Extensive numerical experiments with large-sized instances show that the proposed methods are suitable for solving practical instances of the problem; and that they outperform a half-heuristic-half-exact off-the-shelf solver by a large extent. Numerical experiments with classical instances of the flexible job shop scheduling problem show that the introduced methods are also competitive when applied to this particular case.