According to ARRS' American Journal of Roentgenology (AJR), the combination of deep-learning reconstruction (DLR) and a subtraction technique yielded optimal diagnostic performance for the detection of in-stent restenosis by coronary CTA. Noting that these findings could guide patient selection for invasive coronary stent evaluation, combining DLR with a two-breath-hold subtraction technique "may help overcome challenges related to stent-related blooming artifact," added corresponding author Yi-Ning Wang from the State Key Laboratory of Complex Severe and Rare Diseases at China's Peking Union Medical College Hospital. Between March 2020 and August 2021, Wang and team studied 30 patients (22 men, 8 women; mean age, 63.6 years) with a total of 59 coronary stents who underwent coronary CTA using the two-breath-hold technique (i.e., noncontrast and contrast-enhanced acquisitions). Conventional and subtraction images were reconstructed for hybrid iterative reconstruction (HIR) and DLR, while maximum visible in-stent lumen diameter was measured. Two readers independently evaluated images for in-stent restenosis ( 50% stenosis).

Combining deep-learning reconstruction (DLR) with a subtraction technique yielded optimal diagnostic performance for the detection of in-stent restenosis by coronary CTA, according to a study published in the American Journal or Roentgenology (AJR). Noting that these findings could guide patient selection for invasive coronary stent evaluation, combining DLR with a two-breath-hold subtraction technique "may help overcome challenges related to stent-related blooming artifact," added corresponding author Yi-Ning Wang from the State Key Laboratory of Complex Severe and Rare Diseases at China's Peking Union Medical College Hospital. Between March 2020 and August 2021, Wang and team studied 30 patients (22 men, 8 women; mean age, 63.6 years) with a total of 59 coronary stents who underwent coronary CTA using the two-breath-hold technique (i.e., noncontrast and contrast-enhanced acquisitions). Conventional and subtraction images were reconstructed for hybrid iterative reconstruction (HIR) and DLR, while maximum visible in-stent lumen diameter was measured. Two readers independently evaluated images for in-stent restenosis ( 50% stenosis).

Both readers provided a diagnosis of in-stent restenosis only for subtraction HIR and subtraction DLR. Diagnostic confidence score for the four methods for reader 1 was 2, 2, 3, and 4, respectively, and for reader 2 was 1, 2, 3, and 3, respectively. Patient subsequently underwent invasive catheter angiography. Fluoroscopic imagines obtained (E) before and (F) after contrast media injection demonstrate in-stent restenosis of proximal aspect of stent (arrow). Leesburg, VA, August 10, 2022--According to ARRS' American Journal of Roentgenology (AJR), the combination of deep-learning reconstruction (DLR) and a subtraction technique yielded optimal diagnostic performance for the detection of in-stent restenosis by coronary CTA.

The tool, described in The Lancet Digital Health, accurately predicted which patients would experience a heart attack in five years based on the amount and composition of plaque in arteries that supply blood to the heart. Plaque buildup can cause arteries to narrow, which makes it difficult for blood to get to the heart, increasing the likelihood of a heart attack. A medical test called a coronary computed tomography angiography (CTA) takes 3D images of the heart and arteries and can give doctors an estimate of how much a patient's arteries have narrowed. Until now, however, there has not been a simple, automated and rapid way to measure the plaque visible in the CTA images. "Coronary plaque is often not measured because there is not a fully automated way to do it," said Damini Dey, PhD, director of the quantitative image analysis lab in the Biomedical Imaging Research Institute at Cedars-Sinai and senior author of the study.

Investigators from Cedars-Sinai have created an artificial intelligence-enabled tool that may make it easier to predict if a person will have a heart attack. The tool, described in The Lancet Digital Health, accurately predicted which patients would experience a heart attack in five years based on the amount and composition of plaque in arteries that supply blood to the heart. Plaque buildup can cause arteries to narrow, which makes it difficult for blood to get to the heart, increasing the likelihood of a heart attack. A medical test called a coronary computed tomography angiography (CTA) takes 3D images of the heart and arteries and can give doctors an estimate of how much a patient's arteries have narrowed. Until now, however, there has not been a simple, automated and rapid way to measure the plaque visible in the CTA images.

Investigators from Cedars-Sinai have created an artificial intelligence-enabled tool that may make it easier to predict if a person will have a heart attack. The tool, described in The Lancet Digital Health, accurately predicted which patients would experience a heart attack in five years based on the amount and composition of plaque in arteries that supply blood to the heart. Plaque buildup can cause arteries to narrow, which makes it difficult for blood to get to the heart, increasing the likelihood of a heart attack. A medical test called a coronary computed tomography angiography (CTA) takes 3-D images of the heart and arteries and can give doctors an estimate of how much a patient's arteries have narrowed. Until now, however, there has not been a simple, automated and rapid way to measure the plaque visible in the CTA images.

Developed by a team at Cedars-Sinai, the novel AI technology can accurately forecast early signs of a heart attack, predicting which patients will experience a heart attack in five years based on the level and composition of plaque in arteries that supply the heart with blood. The findings of the team's research, which was funded by the National Heart, Lung, and Blood Institute, are published in The Lancet Digital Health. When plaque builds up, it can result in a narrowing of the arteries, making it more challenging for blood to be transported to the heart, which increases the chances of a heart attack. Traditionally, health professionals employ a medical test called coronary computed tomography angiography (CTA) to capture 3D images of the heart and arteries, which gives the doctors an estimate of how much a patient's arteries have narrowed. However, until now, there has not been an efficient, automated, and rapid method for measuring the plaque shown in the CTA images.