The PD-L1 rate, the number of PD-L1 positive tumor cells over the total number of all tumor cells, is an important metric for immunotherapy. This metric is recorded as diagnostic information with pathological images. In this paper, we propose a proportion estimation method with a small amount of cell-level annotation and proportion annotation, which can be easily collected. Since the PD-L1 rate is calculated from only `tumor cells' and not using `non-tumor cells', we first detect tumor cells with a detection model. Then, we estimate the PD-L1 proportion by introducing a masking technique to `learning from label proportion.' In addition, we propose a weighted focal proportion loss to address data imbalance problems. Experiments using clinical data demonstrate the effectiveness of our method. Our method achieved the best performance in comparisons.

Human epidermal growth factor receptor 2 (HER2) is a critical protein in cancer cell growth that signifies the aggressiveness of breast cancer (BC) and helps predict its prognosis. Accurate assessment of immunohistochemically (IHC) stained tissue slides for HER2 expression levels is essential for both treatment guidance and understanding of cancer mechanisms. Nevertheless, the traditional workflow of manual examination by board-certified pathologists encounters challenges, including inter- and intra-observer inconsistency and extended turnaround times. Here, we introduce a deep learning-based approach utilizing pyramid sampling for the automated classification of HER2 status in IHC-stained BC tissue images. Our approach analyzes morphological features at various spatial scales, efficiently managing the computational load and facilitating a detailed examination of cellular and larger-scale tissue-level details. This method addresses the tissue heterogeneity of HER2 expression by providing a comprehensive view, leading to a blind testing classification accuracy of 84.70%, on a dataset of 523 core images from tissue microarrays. Our automated system, proving reliable as an adjunct pathology tool, has the potential to enhance diagnostic precision and evaluation speed, and might significantly impact cancer treatment planning.

In the thrilling world of oil exploration, drill core samples are key to unlocking geological information critical to finding lucrative oil deposits. Despite the importance of these samples, traditional core logging techniques are known to be laborious and, worse still, subjective. Thankfully, the industry has embraced an innovative solution core imaging that allows for nondestructive and noninvasive rapid characterization of large quantities of drill cores. Our preeminent research paper aims to tackle the pressing problem of core detection and classification. Using state-of-the-art techniques, we present a groundbreaking solution that will transform the industry. Our first challenge is detecting the cores and segmenting the holes in images, which we will achieve using the Faster RCNN and Mask RCNN models, respectively. Then, we will address the problem of filling the hole in the core image, utilizing the powerful Generative Adversarial Networks (GANs) and employing Contextual Residual Aggregation (CRA) to create high-frequency residuals for missing contents in images. Finally, we will apply sophisticated texture recognition models for the classification of core images, revealing crucial information to oil companies in their quest to uncover valuable oil deposits. Our research paper presents an innovative and groundbreaking approach to tackling the complex issues surrounding core detection and classification. By harnessing cutting-edge techniques and technologies, we are poised to revolutionize the industry and make significant contributions to the field of oil exploration.

Core Image is a powerful API built into Cocoa Touch. However, it often gets overlooked. In this tutorial, we're going to examine Core Image's face detection features and how to make use of this technology in your own iOS apps! Face detection in iOS has been around since the days of iOS 5 (circa 2011) but it is often overlooked. The facial detection API allows developers to not only detect faces, but also check those faces for particular properties such as if a smile is present or if the person is blinking. First, we're going to explore Core Image's face detection technology by creating a simple app that recognizes a face in a photo and highlights it with a box.