Domain adversarial training has shown its effective capability for finding domain invariant feature representations and been successfully adopted for various domain adaptation tasks. However, recent advances of large models (e.g., vision transformers) and emerging of complex adaptation scenarios (e.g., DomainNet) make adversarial training being easily biased towards source domain and hardly adapted to target domain. The reason is twofold: relying on large amount of labelled data from source domain for large model training and lacking of labelled data from target domain for fine-tuning. Existing approaches widely focused on either enhancing discriminator or improving the training stability for the backbone networks. Due to unbalanced competition between the feature extractor and the discriminator during the adversarial training, existing solutions fail to function well on complex datasets. To address this issue, we proposed a novel contrastive adversarial training (CAT) approach that leverages the labeled source domain samples to reinforce and regulate the feature generation for target domain. Typically, the regulation forces the target feature distribution being similar to the source feature distribution. CAT addressed three major challenges in adversarial learning: 1) ensure the feature distributions from two domains as indistinguishable as possible for the discriminator, resulting in a more robust domain-invariant feature generation; 2) encourage target samples moving closer to the source in the feature space, reducing the requirement for generalizing classifier trained on the labeled source domain to unlabeled target domain; 3) avoid directly aligning unpaired source and target samples within mini-batch. CAT can be easily plugged into existing models and exhibits significant performance improvements.

There are not many large medical image datasets available. For these datasets, too small deep learning models can't learn useful features, so they don't work well due to underfitting, and too big models tend to overfit the limited data. As a result, there is a compromise between the two issues. This paper proposes a training strategy Medi-CAT to overcome the underfitting and overfitting phenomena in medical imaging datasets. Specifically, the proposed training methodology employs large pre-trained vision transformers to overcome underfitting and adversarial and contrastive learning techniques to prevent overfitting. The proposed method is trained and evaluated on four medical image classification datasets from the MedMNIST collection. Our experimental results indicate that the proposed approach improves the accuracy up to 2% on three benchmark datasets compared to well-known approaches, whereas it increases the performance up to 4.1% over the baseline methods.