The ability to interpret and intervene model decisions is important for the adoption of computer-aided diagnosis methods in clinical workflows. Recent concept-based methods link the model predictions with interpretable concepts and modify their activation scores to interact with the model. However, these concepts are at the image level, which hinders the model from pinpointing the exact patches the concepts are activated. Alternatively, prototype-based methods learn representations from training image patches and compare these with test image patches, using the similarity scores for final class prediction. However, interpreting the underlying concepts of these patches can be challenging and often necessitates post-hoc guesswork. To address this issue, this paper introduces the novel Concept-based Similarity Reasoning network (CSR), which offers (i) patch-level prototype with intrinsic concept interpretation, and (ii) spatial interactivity. First, the proposed CSR provides localized explanation by grounding prototypes of each concept on image regions. Second, our model introduces novel spatial-level interaction, allowing doctors to engage directly with specific image areas, making it an intuitive and transparent tool for medical imaging. CSR improves upon prior state-of-the-art interpretable methods by up to 4.5\% across three biomedical datasets. Our code is released at https://github.com/tadeephuy/InteractCSR.

Recent advancements in post-hoc and inherently interpretable methods have markedly enhanced the explanations of black box classifier models. These methods operate either through post-analysis or by integrating concept learning during model training. Although being effective in bridging the semantic gap between a model's latent space and human interpretation, these explanation methods only partially reveal the model's decision-making process. The outcome is typically limited to high-level semantics derived from the last feature map. We argue that the explanations lacking insights into the decision processes at low and mid-level features are neither fully faithful nor useful. Addressing this gap, we introduce the Multi-Level Concept Prototypes Classifier (MCPNet), an inherently interpretable model. MCPNet autonomously learns meaningful concept prototypes across multiple feature map levels using Centered Kernel Alignment (CKA) loss and an energy-based weighted PCA mechanism, and it does so without reliance on predefined concept labels. Further, we propose a novel classifier paradigm that learns and aligns multi-level concept prototype distributions for classification purposes via Class-aware Concept Distribution (CCD) loss. Our experiments reveal that our proposed MCPNet while being adaptable to various model architectures, offers comprehensive multi-level explanations while maintaining classification accuracy. Additionally, its concept distribution-based classification approach shows improved generalization capabilities in few-shot classification scenarios.

Developing algorithms that are able to generalize to a novel task given only a few labeled examples represents a fundamental challenge in closing the gap between machine- and human-level performance. The core of human cognition lies in the structured, reusable concepts that help us to rapidly adapt to new tasks and provide reasoning behind our decisions. However, existing meta-learning methods learn complex representations across prior labeled tasks without imposing any structure on the learned representations. Here we propose COMET, a meta-learning method that improves generalization ability by learning to learn along human-interpretable concept dimensions. Instead of learning a joint unstructured metric space, COMET learns mappings of high-level concepts into semi-structured metric spaces, and effectively combines the outputs of independent concept learners. We evaluate our model on few-shot tasks from diverse domains, including a benchmark image classification dataset and a novel single-cell dataset from a biological domain developed in our work. COMET significantly outperforms strong meta-learning baselines, achieving $9$-$12\%$ average improvement on the most challenging $1$-shot learning tasks, while unlike existing methods also providing interpretations behind the model's predictions.