Generative AI's rapid advancement sparks interest in its cognitive abilities, especially given its capacity for tasks like language understanding and code generation. This study explores how several recent GenAI models perform on the Clock Drawing Test (CDT), a neuropsychological assessment of visuospatial planning and organization. While models create clock-like drawings, they struggle with accurate time representation, showing deficits similar to mild-severe cognitive impairment (Wechsler, 2009). Errors include numerical sequencing issues, incorrect clock times, and irrelevant additions, despite accurate rendering of clock features. Only GPT 4 Turbo and Gemini Pro 1.5 produced the correct time, scoring like healthy individuals (4/4). A follow-up clock-reading test revealed only Sonnet 3.5 succeeded, suggesting drawing deficits stem from difficulty with numerical concepts. These findings may reflect weaknesses in visual-spatial understanding, working memory, or calculation, highlighting strengths in learned knowledge but weaknesses in reasoning. Comparing human and machine performance is crucial for understanding AI's cognitive capabilities and guiding development toward human-like cognitive functions.

The integration of different imaging modalities, such as structural, diffusion tensor, and functional magnetic resonance imaging, with deep learning models has yielded promising outcomes in discerning phenotypic characteristics and enhancing disease diagnosis. The development of such a technique hinges on the efficient fusion of heterogeneous multimodal features, which initially reside within distinct representation spaces. Naively fusing the multimodal features does not adequately capture the complementary information and could even produce redundancy. In this work, we present a novel joint self-supervised and supervised contrastive learning method to learn the robust latent feature representation from multimodal MRI data, allowing the projection of heterogeneous features into a shared common space, and thereby amalgamating both complementary and analogous information across various modalities and among similar subjects. We performed a comparative analysis between our proposed method and alternative deep multimodal learning approaches. Through extensive experiments on two independent datasets, the results demonstrated that our method is significantly superior to several other deep multimodal learning methods in predicting abnormal neurodevelopment. Our method has the capability to facilitate computer-aided diagnosis within clinical practice, harnessing the power of multimodal data.

For many of us, hazard perception was one of the more fun and less nerve-wracking parts of the driving test. But if spotting the unexpected doesn't fall within your skillset, scientists warn you may experience'inattentional blindness'. Researchers at New York University (NYU) have recreated the classic'invisible gorilla test' from over 20 years ago in an effort to understand our capabilities. More than 1,500 participants were shown unsuspecting footage of six people throwing two basketballs between them. While viewers were asked to simply count how many times those wearing white pass the ball, this was not the real test at all.

Structural magnetic resonance imaging studies have shown that brain anatomical abnormalities are associated with cognitive deficits in preterm infants. Brain maturation and geometric features can be used with machine learning models for predicting later neurodevelopmental deficits. However, traditional machine learning models would suffer from a large feature-to-instance ratio (i.e., a large number of features but a small number of instances/samples). Ensemble learning is a paradigm that strategically generates and integrates a library of machine learning classifiers and has been successfully used on a wide variety of predictive modeling problems to boost model performance. Attribute (i.e., feature) bagging method is the most commonly used feature partitioning scheme, which randomly and repeatedly draws feature subsets from the entire feature set. Although attribute bagging method can effectively reduce feature dimensionality to handle the large feature-to-instance ratio, it lacks consideration of domain knowledge and latent relationship among features. In this study, we proposed a novel Ontology-guided Attribute Partitioning (OAP) method to better draw feature subsets by considering the domain-specific relationship among features. With the better partitioned feature subsets, we developed an ensemble learning framework, which is referred to as OAP-Ensemble Learning (OAP-EL). We applied the OAP-EL to predict cognitive deficits at 2 years of age using quantitative brain maturation and geometric features obtained at term equivalent age in very preterm infants. We demonstrated that the proposed OAP-EL approach significantly outperformed the peer ensemble learning and traditional machine learning approaches.

LONDON – People recovering from COVID-19 may suffer significant brain function impacts, with the worst cases of the infection linked to mental decline equivalent to the brain ageing by 10 years, researchers warned on Tuesday. A nonpeer-reviewed study of more than 84,000 people, led by Adam Hampshire, a doctor at Imperial College London, found that in some severe cases, coronavirus infection is linked to substantial cognitive deficits for months. "Our analyses … align with the view that there are chronic cognitive consequences of having COVID-19," the researchers wrote in a report of their findings. "People who had recovered, including those no longer reporting symptoms, exhibited significant cognitive deficits." Cognitive tests measure how well the brain performs tasks -- such as remembering words or joining dots on a puzzle.

The accurate diagnosis and assessment of neurodegenerative disease and traumatic brain injuries (TBI) remain open challenges. Both cause cognitive and functional deficits due to focal axonal swellings (FAS), but it is difficult to deliver a prognosis due to our limited ability to assess damaged neurons at a cellular level in vivo. We simulate the effects of neurodegenerative disease and TBI using convolutional neural networks (CNNs) as our model of cognition. We utilize biophysically relevant statistical data on FAS to damage the connections in CNNs in a functionally relevant way. We incorporate energy constraints on the brain by pruning the CNNs to be less over-engineered. Qualitatively, we demonstrate that damage leads to human-like mistakes. Our experiments also provide quantitative assessments of how accuracy is affected by various types and levels of damage. The deficit resulting from a fixed amount of damage greatly depends on which connections are randomly injured, providing intuition for why it is difficult to predict impairments. There is a large degree of subjectivity when it comes to interpreting cognitive deficits from complex systems such as the human brain. However, we provide important insight and a quantitative framework for disorders in which FAS are implicated.