Measuring GUI task difficulty is crucial for user behavior analysis and agent capability evaluation. Yet, existing benchmarks typically quantify difficulty based on motor actions (e.g., step counts), overlooking the cognitive demands underlying task completion. In this work, we propose Cognitive Chain, a novel framework that models task difficulty from a cognitive perspective. A cognitive chain decomposes the cognitive processes preceding a motor action into a sequence of cognitive steps (e.g., finding, deciding, computing), each with a difficulty index grounded in information theories. We develop an LLM-based method to automatically extract cognitive chains from task execution traces. Validation with linear regression shows that our estimated cognitive difficulty correlates well with user completion time (step-level R-square=0.46 after annotation). Assessment of state-of-the-art GUI agents shows reduced success on cognitively demanding tasks, revealing capability gaps and Human-AI consistency patterns. We conclude by discussing potential applications in agent training, capability assessment, and human-agent delegation optimization.

Multimodal large language models (MLLMs) demonstrate significant potential in the field of medical diagnosis. However, they face critical challenges in specialized domains such as ophthalmology, particularly the fragmentation of annotation granularity and inconsistencies in clinical reasoning logic, which hinder precise cross-modal understanding. This paper introduces FundusExpert, an ophthalmology-specific MLLM with integrated positioning-diagnosis reasoning capabilities, along with FundusGen, a dataset constructed through the intelligent Fundus-Engine system. Fundus-Engine automates localization and leverages MLLM-based semantic expansion to integrate global disease classification, local object detection, and fine-grained feature analysis within a single fundus image. Additionally, by constructing a clinically aligned cognitive chain, it guides the model to generate interpretable reasoning paths. FundusExpert, fine-tuned with instruction data from FundusGen, achieves the best performance in ophthalmic question-answering tasks, surpassing the average accuracy of the 40B MedRegA by 26.6%. It also excels in zero-shot report generation tasks, achieving a clinical consistency of 77.0%, significantly outperforming GPT-4o's 47.6%. Furthermore, we reveal a scaling law between data quality and model capability ($L \propto N^{0.068}$), demonstrating that the cognitive alignment annotations in FundusGen enhance data utilization efficiency. By integrating region-level localization with diagnostic reasoning chains, our work develops a scalable, clinically-aligned MLLM and explores a pathway toward bridging the visual-language gap in specific MLLMs. Our project can be found at https://github.com/MeteorElf/FundusExpert.

Theory of mind (ToM) refers to humans' ability to understand and infer the desires, beliefs, and intentions of others. The acquisition of ToM plays a key role in humans' social cognition and interpersonal relations. Though indispensable for social intelligence, ToM is still lacking for modern AI and NLP systems since they cannot access the human mental state and cognitive process beneath the training corpus. To empower AI systems with the ToM ability and narrow the gap between them and humans, in this paper, we propose COKE: the first cognitive knowledge graph for machine theory of mind. Specifically, COKE formalizes ToM as a collection of 45k+ manually verified cognitive chains that characterize human mental activities and subsequent behavioral/affective responses when facing specific social circumstances. Beyond that, we further generalize COKE using pre-trained language models and build a powerful cognitive generation model COKE+. Experimental results in both automatic and human evaluation demonstrate the high quality of COKE and the superior ToM ability of COKE+.