The left side shows the effect of pruning of neurons in the weight-matrix of afully-connected layer. The rows in white correspond to neurons pruned in theassociated layer while thecolumns inwhite represent theeffectofremoving neurons from the previous layers. On the right, we allude to the possibility of collapsing the pruned matrix into a smaller,denseone.

B.6 EvaluationMetrics We use two traditional metrics, MSE (or PSNR) and SSIM [51], and a recently proposed deeplearning-based metric LPIPS [52], which measures the similarity between features from different

IMPORTANCE Women are underdiagnosed and undertreated for cardiovascular disease. Automatic quantification of breast arterial calcification on screening mammography can identify women at risk for cardiovascular disease and enable earlier treatment and management of disease. OBJECTIVE To determine whether artificial-intelligence based automatic quantification of BAC from screening mammograms predicts cardiovascular disease and mortality in a large, racially diverse, multi-institutional population, both independently and beyond traditional risk factors and ASCVD scores. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study of 116,135 women from two healthcare systems (Emory Healthcare and Mayo Clinic Enterprise) who had screening mammograms and either experienced a major adverse cardiovascular event, death, or had at least 5 years of clinical follow-up. BAC was quantified using a novel transformer-based neural network architecture for semantic segmentation. BAC severity was categorized into four groups (no BAC, mild, moderate, and severe), with outcomes assessed using Kaplan-Meier analysis and Cox proportional-hazards models. MAIN OUTCOMES AND MEASURES Major Adverse Cardiovascular Events (MACE), including acute myocardial infarction, stroke, heart failure, and all-cause mortality, adjusted for traditional risk factors and Atherosclerotic CVD (ASCVD) risk scores. RESULTS BAC severity was independently associated with MACE after adjusting for cardiovascular risk factors, with increasing hazard ratios from mild (HR 1.18-1.22),

Background: Myocardial perfusion reflects the macro- and microvascular coronary circulation. Recent quantitation developments using cardiovascular magnetic resonance (CMR) perfusion permit automated measurement clinically. We explored the prognostic significance of stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR, the ratio of stress to rest MBF). Methods: A two center study of patients with both suspected and known coronary artery disease referred clinically for perfusion assessment. Image analysis was performed automatically using a novel artificial intelligence approach deriving global and regional stress and rest MBF and MPR.

Click-through data has proven to be a valuable resource for improving search-ranking quality. Search engines can easily collect click data, but biases introduced in the data can make it difficult to use the data effectively. In order to measure the effects of biases, many click models have been proposed in the literature. However, none of the models can explain the observation that users with different search intent (e.g., informational, navigational, etc.) have different click behaviors. In this paper, we study how differences in user search intent can influence click activities and determined that there exists a bias between user search intent and the relevance of the document relevance. Based on this observation, we propose a search intent bias hypothesis that can be applied to most existing click models to improve their ability to learn unbiased relevance. Experimental results demonstrate that after adopting the search intent hypothesis, click models can better interpret user clicks and substantially improve retrieval performance.