However, the conditions under which this extrapolation can be legitimized have not been formally articulateduntilveryrecently.

This paper considers the problem of transferring experimental findings learned from multiple heterogeneous domains to a target domain, in which only limited experiments can be performed. We reduce questions of transportability from multiple domains and with limited scope to symbolic derivations in the causal calculus, thus extending the original setting of transportability introduced in [1], which assumes only one domain with full experimental information available. We further provide different graphical and algorithmic conditions for computing the transport formula in this setting, that is, a way of fusing the observational and experimental information scattered throughout different domains to synthesize a consistent estimate of the desired effects in the target domain. We also consider the issue of minimizing the variance of the produced estimand in order to increase power.

We prove the main rules of causal calculus (also called do-calculus) for interventional structural causal models (iSCMs), a generalization of a recently proposed general class of non-/linear structural causal models that allow for cycles, latent confounders and arbitrary probability distributions. We also generalize adjustment criteria and formulas from the acyclic setting to the general one (i.e. iSCMs). Such criteria then allow to estimate (conditional) causal effects from observational data that was (partially) gathered under selection bias and cycles. This generalizes the backdoor criterion, the selection-backdoor criterion and extensions of these to arbitrary iSCMs. Together, our results thus enable causal reasoning in the presence of cycles, latent confounders and selection bias.

We provide a logical representation of Pearl's structural causal models in the causal calculus of McCain and Turner (1997) and its first-order generalization by Lifschitz. It will be shown that, under this representation, the nonmonotonic semantics of the causal calculus describes precisely the solutions of the structural equations (the causal worlds of the causal model), while the causal logic from Bochman (2004) is adequate for describing the behavior of causal models under interventions (forming submodels).

Despite the major advances taken in causal modeling, causality is still an unfamiliar topic for many statisticians. In this paper, it is demonstrated from the beginning to the end how causal effects can be estimated from observational data assuming that the causal structure is known. To make the problem more challenging, the causal effects are highly nonlinear and the data are missing at random. The tools used in the estimation include causal models with design, causal calculus, multiple imputation and generalized additive models. The main message is that a trained statistician can estimate causal effects by judiciously combining existing tools.

The causal assumptions, the study design and the data are the elements required for scientific inference in empirical research. The research is adequately communicated only if all of these elements and their relations are described precisely. Causal models with design describe the study design and the missing data mechanism together with the causal structure and allow the direct application of causal calculus in the estimation of the causal effects. The flow of the study is visualized by ordering the nodes of the causal diagram in two dimensions by their causal order and the time of the observation. Conclusions whether a causal or observational relationship can be estimated from the collected incomplete data can be made directly from the graph. Causal models with design offer a systematic and unifying view scientific inference and increase the clarity and speed of communication. Examples on the causal models for a case-control study, a nested case-control study, a clinical trial and a two-stage case-cohort study are presented.

This paper considers the problem of transferring experimental findings learned from multiple heterogeneous domains to a target domain, in which only limited experiments can be performed. We reduce questions of transportability from multiple domainsand with limited scope to symbolic derivations in the causal calculus, thus extending the original setting of transportability introduced in [1], which assumes only one domain with full experimental information available. We further provide different graphical and algorithmic conditions for computing the transport formula in this setting, that is, a way of fusing the observational and experimental informationscattered throughout different domains to synthesize a consistent estimate of the desired effects in the target domain. We also consider the issue of minimizing the variance of the produced estimand in order to increase power.