R2: how the final prediction is made. The prediction is made using the averaged logits across the locations.

Colon cancer also known as Colorectal cancer, is one of the most malignant types of cancer worldwide. Early-stage detection of colon cancer is highly crucial to prevent its deterioration. This research presents a hybrid multi-scale deep learning architecture that synergizes capsule networks, graph attention mechanisms, transformer modules, and residual learning to advance colon cancer classification on the Lung and Colon Cancer Histopathological Image Dataset (LC25000) dataset. The proposed model in this paper utilizes the HG-TNet model that introduces a hybrid architecture that joins strength points in transformers and convolutional neural networks to capture multi-scale features in histopathological images. Mainly, a transformer branch extracts global contextual bonds by partitioning the image into patches by convolution-based patch embedding and then processing these patches through a transformer encoder. Analogously, a dedicated CNN branch captures fine-grained, local details through successive Incorporation these diverse features, combined with a self-supervised rotation prediction objective, produce a robust diagnostic representation that surpasses standard architectures in performance. Results show better performance not only in accuracy or loss function but also in these algorithms by utilizing capsule networks to preserve spatial orders and realize how each element individually combines and forms whole structures.

Accurate and scalable cancer diagnosis remains a critical challenge in modern pathology, particularly for malignancies such as breast, prostate, bone, and cervical, which exhibit complex histological variability. In this study, we propose a transformer-based deep learning framework for multi-class tumor classification in histopathological images. Leveraging a fine-tuned Vision Transformer (ViT) architecture, our method addresses key limitations of conventional convolutional neural networks, offering improved performance, reduced preprocessing requirements, and enhanced scalability across tissue types. To adapt the model for histopathological cancer images, we implement a streamlined preprocessing pipeline that converts tiled whole-slide images into PyTorch tensors and standardizes them through data normalization. This ensures compatibility with the ViT architecture and enhances both convergence stability and overall classification performance. We evaluate our model on four benchmark datasets: ICIAR2018 (breast), SICAPv2 (prostate), UT-Osteosarcoma (bone), and SipakMed (cervical) dataset -- demonstrating consistent outperformance over existing deep learning methods. Our approach achieves classification accuracies of 99.32%, 96.92%, 95.28%, and 96.94% for breast, prostate, bone, and cervical cancers respectively, with area under the ROC curve (AUC) scores exceeding 99% across all datasets. These results confirm the robustness, generalizability, and clinical potential of transformer-based architectures in digital pathology. Our work represents a significant advancement toward reliable, automated, and interpretable cancer diagnosis systems that can alleviate diagnostic burdens and improve healthcare outcomes.

The rapid advancement of deep learning in medical image analysis has greatly enhanced the accuracy of skin cancer classification. However, current state-of-the-art models, especially those based on transfer learning like ResNet50, come with significant computational overhead, rendering them impractical for deployment in resource-constrained environments. This study proposes a custom CNN model that achieves a 96.7\% reduction in parameters (from 23.9 million in ResNet50 to 692,000) while maintaining a classification accuracy deviation of less than 0.022\%. Our empirical analysis of the HAM10000 dataset reveals that although transfer learning models provide a marginal accuracy improvement of approximately 0.022\%, they result in a staggering 13,216.76\% increase in FLOPs, considerably raising computational costs and inference latency. In contrast, our lightweight CNN architecture, which encompasses only 30.04 million FLOPs compared to ResNet50's 4.00 billion, significantly reduces energy consumption, memory footprint, and inference time. These findings underscore the trade-off between the complexity of deep models and their real-world feasibility, positioning our optimized CNN as a practical solution for mobile and edge-based skin cancer diagnostics.

The integration of multi-omics data presents a major challenge in precision medicine, requiring advanced computational methods for accurate disease classification and biological interpretation. This study introduces the Multi-Omics Graph Kolmogorov-Arnold Network (MOGKAN), a deep learning model that integrates messenger RNA, micro RNA sequences, and DNA methylation data with Protein-Protein Interaction (PPI) networks for accurate and interpretable cancer classification across 31 cancer types. MOGKAN employs a hybrid approach combining differential expression with DESeq2, Linear Models for Microarray (LIMMA), and Least Absolute Shrinkage and Selection Operator (LASSO) regression to reduce multi-omics data dimensionality while preserving relevant biological features. The model architecture is based on the Kolmogorov-Arnold theorem principle, using trainable univariate functions to enhance interpretability and feature analysis. MOGKAN achieves classification accuracy of 96.28 percent and demonstrates low experimental variability with a standard deviation that is reduced by 1.58 to 7.30 percents compared to Convolutional Neural Networks (CNNs) and Graph Neural Networks (GNNs). The biomarkers identified by MOGKAN have been validated as cancer-related markers through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The proposed model presents an ability to uncover molecular oncogenesis mechanisms by detecting phosphoinositide-binding substances and regulating sphingolipid cellular processes. By integrating multi-omics data with graph-based deep learning, our proposed approach demonstrates superior predictive performance and interpretability that has the potential to enhance the translation of complex multi-omics data into clinically actionable cancer diagnostics.

Breast cancer remains one of the leading causes of cancer-related deaths worldwide. Early detection is crucial for improving patient outcomes, yet the diagnostic process is often complex and prone to inconsistencies among pathologists. Computer-aided diagnostic approaches have significantly enhanced breast cancer detection, particularly in binary classification (benign vs. malignant). However, these methods face challenges in multiclass classification, leading to frequent mispredictions. In this work, we propose a novel adaptive learning approach for multiclass breast cancer classification using H&E-stained histopathology images. First, we introduce a misprediction risk analysis framework that quantifies and ranks the likelihood of an image being mislabeled by a classifier. This framework leverages an interpretable risk model that requires only a small number of labeled samples for training. Next, we present an adaptive learning strategy that fine-tunes classifiers based on the specific characteristics of a given dataset. This approach minimizes misprediction risk, allowing the classifier to adapt effectively to the target workload. We evaluate our proposed solutions on real benchmark datasets, demonstrating that our risk analysis framework more accurately identifies mispredictions compared to existing methods. Furthermore, our adaptive learning approach significantly improves the performance of state-of-the-art deep neural network classifiers.

One of the deadliest cancers, lung cancer necessitates an early and precise diagnosis. Because patients have a better chance of recovering, early identification of lung cancer is crucial. This review looks at how to diagnose lung cancer using sophisticated machine learning techniques like Random Forest (RF) and Support Vector Machine (SVM). The Chi-squared test is one feature selection strategy that has been successfully applied to find related features and enhance model performance. The findings demonstrate that these techniques can improve detection efficiency and accuracy while also assisting in runtime reduction. This study produces recommendations for further research as well as ideas to enhance diagnostic techniques. In order to improve healthcare and create automated methods for detecting lung cancer, this research is a critical first step.

Molecular subtyping of cancer is recognized as a critical and challenging upstream task for personalized therapy. Existing deep learning methods have achieved significant performance in this domain when abundant data samples are available. However, the acquisition of densely labeled samples for cancer molecular subtypes remains a significant challenge for conventional data-intensive deep learning approaches. In this work, we focus on the few-shot molecular subtype prediction problem in heterogeneous and small cancer datasets, aiming to enhance precise diagnosis and personalized treatment. We first construct a new few-shot dataset for cancer molecular subtype classification and auxiliary cancer classification, named TCGA Few-Shot, from existing publicly available datasets. To effectively leverage the relevant knowledge from both tasks, we introduce a task-specific embedding-based meta-learning framework (TSEML). TSEML leverages the synergistic strengths of a model-agnostic meta-learning (MAML) approach and a prototypical network (ProtoNet) to capture diverse and fine-grained features. Comparative experiments conducted on the TCGA Few-Shot dataset demonstrate that our TSEML framework achieves superior performance in addressing the problem of few-shot molecular subtype classification.

Breast cancer detection based on pre-trained convolution neural network (CNN) has gained much interest among other conventional computer-based systems. In the past few years, CNN technology has been the most promising way to find cancer in mammogram scans. In this paper, the effect of layer freezing in a pre-trained CNN is investigated for breast cancer detection by classifying mammogram images as benign or malignant. Different VGG19 scenarios have been examined based on the number of convolution layer blocks that have been frozen. There are a total of six scenarios in this study. The primary benefits of this research are twofold: it improves the model's ability to detect breast cancer cases and it reduces the training time of VGG19 by freezing certain layers.To evaluate the performance of these scenarios, 1693 microbiological images of benign and malignant breast cancers were utilized. According to the reported results, the best recognition rate was obtained from a frozen first block of VGG19 with a sensitivity of 95.64 %, while the training of the entire VGG19 yielded 94.48%.