The Computer_Aided Diagnosis (CAD) systems facilitate accurate diagnosis of diseases. The development of CADs by leveraging third generation neural network, namely, Spiking Neural Network (SNN), is essential to utilize of the benefits of SNNs, such as their event_driven processing, parallelism, low power consumption, and the ability to process sparse temporal_spatial information. However, Deep SNN as a deep learning model faces challenges with unreliability. To deal with unreliability challenges due to inability to quantify the uncertainty of the predictions, we proposed a deep Bayesian Convolutional Spiking Neural Network based_CADs with uncertainty_aware module. In this study, the Monte Carlo Dropout method as Bayesian approximation is used as an uncertainty quantification method. This method was applied to several medical image classification tasks. Our experimental results demonstrate that our proposed model is accurate and reliable and will be a proper alternative to conventional deep learning for medical image classification.

Cervical cancer stands as a predominant cause of female mortality, underscoring the need for regular screenings to enable early diagnosis and preemptive treatment of pre-cancerous conditions. The transformation zone in the cervix, where cellular differentiation occurs, plays a critical role in the detection of abnormalities. Colposcopy has emerged as a pivotal tool in cervical cancer prevention since it provides a meticulous examination of cervical abnormalities. However, challenges in visual evaluation necessitate the development of Computer Aided Diagnosis (CAD) systems. We propose a novel CAD system that combines the strengths of various deep-learning descriptors (ResNet50, ResNet101, and ResNet152) with appropriate feature normalization (min-max) as well as feature reduction technique (LDA). The combination of different descriptors ensures that all the features (low-level like edges and colour, high-level like shape and texture) are captured, feature normalization prevents biased learning, and feature reduction avoids overfitting. We do experiments on the IARC dataset provided by WHO. The dataset is initially segmented and balanced. Our approach achieves exceptional performance in the range of 97%-100% for both the normal-abnormal and the type classification. A competitive approach for type classification on the same dataset achieved 81%-91% performance.

Alzheimer's disease is a severe neurological brain disorder. It is not curable, but earlier detection can help improve symptoms in a great deal. The machine learning-based approaches are popular and well-motivated models for many medical image processing tasks such as computer-aided diagnosis. These techniques can vastly improve the process for accurate diagnosis of Alzheimer's disease. In this paper, we investigate the performance of these techniques for Alzheimer's disease detection and classification using brain MRI and PET images from the OASIS database. The proposed system takes advantage of the powerful artificial neural network and support vector machines as classifiers, as well as principal component analysis as a feature extraction technique. The results indicate that the combined scheme achieves good accuracy and offers a significant advantage over the other approaches.

Breast cancer is a serious disease that inflicts millions of people each year, and the number of cases is increasing. Early detection is the best way to reduce the impact of the disease. Researchers have developed many techniques to detect breast cancer, including the use of histopathology images in CAD systems. This research proposes a technique that combine already fully trained model using adaptive average ensemble, this is different from the literature which uses average ensemble before training and the average ensemble is trained simultaneously. Our approach is different because it used adaptive average ensemble after training which has increased the performance of evaluation metrics. It averages the outputs of every trained model, and every model will have weight according to its accuracy. The accuracy in the adaptive weighted ensemble model has achieved 98% where the accuracy has increased by 1 percent which is better than the best participating model in the ensemble which was 97%. Also, it decreased the numbers of false positive and false negative and enhanced the performance metrics.

Deep neural networks (DNNs) have promoted the development of computer aided diagnosis (CAD) systems for fundus diseases, helping ophthalmologists reduce missed diagnosis and misdiagnosis rate. However, the majority of CAD systems are data-driven but lack of medical prior knowledge which can be performance-friendly. In this regard, we innovatively proposed a human-in-the-loop (HITL) CAD system by leveraging ophthalmologists' eye-tracking information, which is more efficient and accurate. Concretely, the HITL CAD system was implemented on the multiple instance learning (MIL), where eye-tracking gaze maps were beneficial to cherry-pick diagnosis-related instances. Furthermore, the dual-cross-attention MIL (DCAMIL) network was utilized to curb the adverse effects of noisy instances. Meanwhile, both sequence augmentation module and domain adversarial module were introduced to enrich and standardize instances in the training bag, respectively, thereby enhancing the robustness of our method. We conduct comparative experiments on our newly constructed datasets (namely, AMD-Gaze and DR-Gaze), respectively for the AMD and early DR detection. Rigorous experiments demonstrate the feasibility of our HITL CAD system and the superiority of the proposed DCAMIL, fully exploring the ophthalmologists' eye-tracking information. These investigations indicate that physicians' gaze maps, as medical prior knowledge, is potential to contribute to the CAD systems of clinical diseases.

Iacucci and her colleagues recruited patients from 11 international centers between September 2016 and November 2019. Eligible participants had a confirmed diagnosis of ulcerative colitis for at least one year without regard to disease activity and an indication for a colonoscopy. At least two tissue samples were obtained from the rectum and the sigmoid because they are common areas representative of healing and inflammation. The endoscopic exam was recorded in the same area. Clinical outcomes used as proxies for disease flare-ups for the purpose of prognosis assessment included ulcerative colitis-related hospitalizations or surgery and increase in initiation of or changes in ulcerative colitis treatments, such as immunomodulators, biologics, or steroids, due to worsening symptoms.

PolyDeep is a research project that seeks to improve the detection and classification of colorectal polyps through colonoscopies. To achieve this, PolyDeep proposes the development of a CAD system to assist the endoscopist during the endoscopy. The core of this CAD system consists of two Deep Learning models, one for detection and another one for classification, developed using a new polyp video and image dataset created in collaboration with the CHUO Hospital (Ourense, Spain).

Researchers at Duke University Medical Center have developed a deep-learning-based computer-aided detection (CAD) system to identify difficult-to-detect brain metastases on MR images. The algorithm exhibited excellent sensitivity and specificity, outperforming other CAD systems in development. The tool shows potential to enable earlier identification of emerging brain metastases, allowing them to be targeted with stereotactic radiosurgery (SRS) when they first appear and, for some patients, reducing the number of required treatments. SRS, which uses precisely focused photon beams to deliver a high dose of radiation to targets in the brain in a single radiotherapy session, is evolving into the standard-of-care treatment for patients with a limited number of brain metastases. To target a metastasis, however, it must first be identified on an MR image.

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification from the convolutional neural networks (CNN) are demonstrated in this study to provide comprehensive interpretability for the proposed CAD system using pathological knowledge. Methods: In the experiment, a total of 186 slides of WSIs were collected and classified into three categories: Non-Carcinoma, Ductal Carcinoma in Situ (DCIS), and Invasive Ductal Carcinoma (IDC). Instead of conducting pixel-wise classification into three classes directly, we designed a hierarchical framework with the multi-view scheme that performs lesion detection for region proposal at higher magnification first and then conducts lesion classification at lower magnification for each detected lesion. Results: The slide-level accuracy rate for three-category classification reaches 90.8% (99/109) through 5-fold cross-validation and achieves 94.8% (73/77) on the testing set. The experimental results show that the morphological characteristics and co-occurrence properties learned by the deep learning models for lesion classification are accordant with the clinical rules in diagnosis. Conclusion: The pathological interpretability of the deep features not only enhances the reliability of the proposed CAD system to gain acceptance from medical specialists, but also facilitates the development of deep learning frameworks for various tasks in pathology. Significance: This paper presents a CAD system for pathological image analysis, which fills the clinical requirements and can be accepted by medical specialists with providing its interpretability from the pathological perspective.

Melanoma is a leading cause of deaths due to skin cancer deaths and hence, early and effective diagnosis of melanoma is of interest. Current approaches for automated diagnosis of melanoma either use pattern recognition or analytical recognition like ABCDE (asymmetry, border, color, diameter and evolving) criterion. In practice however, a differential approach wherein outliers (ugly duckling) are detected and used to evaluate nevi/lesions. Incorporation of differential recognition in Computer Aided Diagnosis (CAD) systems has not been explored but can be beneficial as it can provide a clinical justification for the derived decision. We present a method for identifying and quantifying ugly ducklings by performing Intra-Patient Comparative Analysis (IPCA) of neighboring nevi. This is then incorporated in a CAD system design for melanoma detection. This design ensures flexibility to handle cases where IPCA is not possible. Our experiments on a public dataset show that the outlier information helps boost the sensitivity of detection by at least 4.1 % and specificity by 4.0 % to 8.9 %, depending on the use of a strong (EfficientNet) or moderately strong (VGG or ResNet) classifier.