Precise and accurate predictions over boundary areas are essential for semantic segmentation.

Gaussian processes (GPs) are broadly used as surrogate models for expensive computer simulators of complex phenomena. However, a key bottleneck is that its training data are generated from this expensive simulator and thus can be highly limited. A promising solution is to supplement the learning model with boundary information from scientific knowledge. However, despite recent work on boundary-integrated GPs, such models largely cannot accommodate boundary information on irregular (i.e., non-hypercube) domains, and do not provide sample path smoothness control or approximation error analysis, both of which are important for reliable surrogate modeling. We thus propose a novel BdryMatérn GP modeling framework, which can reliably integrate Dirichlet, Neumann and Robin boundaries on an irregular connected domain with a boundary set that is twice-differentiable almost everywhere. Our model leverages a new BdryMatérn covariance kernel derived in path integral form via a stochastic partial differential equation formulation. Similar to the GP with Matérn kernel, we prove that sample paths from the BdryMatérn GP satisfy the desired boundaries with smoothness control on its derivatives. We further present an efficient approximation procedure for the BdryMatérn kernel using finite element modeling with rigorous error analysis. Finally, we demonstrate the effectiveness of the BdryMatérn GP in a suite of numerical experiments on incorporating broad boundaries on irregular domains.

Spatial transcriptomics (ST) has emerged as an advanced technology that provides spatial context to gene expression. Recently, deep learning-based methods have shown the capability to predict gene expression from WSI data using ST data. Existing approaches typically extract features from images and the neighboring regions using pretrained models, and then develop methods to fuse this information to generate the final output. However, these methods often fail to account for the cellular structure similarity, cellular density and the interactions within the microenvironment. In this paper, we propose a framework named BG-TRIPLEX, which leverages boundary information extracted from pathological images as guiding features to enhance gene expression prediction from WSIs. Specifically, our model consists of three branches: the spot, in-context and global branches. In the spot and in-context branches, boundary information, including edge and nuclei characteristics, is extracted using pretrained models. These boundary features guide the learning of cellular morphology and the characteristics of microenvironment through Multi-Head Cross-Attention. Finally, these features are integrated with global features to predict the final output. Extensive experiments were conducted on three public ST datasets. The results demonstrate that our BG-TRIPLEX consistently outperforms existing methods in terms of Pearson Correlation Coefficient (PCC). This method highlights the crucial role of boundary features in understanding the complex interactions between WSI and gene expression, offering a promising direction for future research.

Dermoscopy requires a welltrained physician with experience and visual ability, while Skin cancer is a highly dangerous type of cancer that requires skin biopsy involves taking a sample of skin from the patient's an accurate diagnosis from experienced physicians. To help body, which can be a slow and painful process. These difficulties physicians diagnose skin cancer more efficiently, a computeraided have spurred researchers in the field of artificial intelligence diagnosis (CAD) system can be very helpful. In this (AI) to create Computer-Aided Diagnosis (CAD) systems paper, we propose a novel model, which uses a novel attention capable of precise skin cancer classification. However, mechanism to pinpoint the differences in features across due to the inter-class similarity and intra-class dissimilarity the spatial dimensions and symmetry of the lesion, thereby focusing among different types of skin cancer, classifying skin cancer on the dissimilarities of various classes based on symmetry, using medical image processing is a challenging issue.

Polyp segmentation for colonoscopy images is of vital importance in clinical practice. It can provide valuable information for colorectal cancer diagnosis and surgery. While existing methods have achieved relatively good performance, polyp segmentation still faces the following challenges: (1) Varying lighting conditions in colonoscopy and differences in polyp locations, sizes, and morphologies. (2) The indistinct boundary between polyps and surrounding tissue. To address these challenges, we propose a Multi-scale information sharing and selection network (MISNet) for polyp segmentation task. We design a Selectively Shared Fusion Module (SSFM) to enforce information sharing and active selection between low-level and high-level features, thereby enhancing model's ability to capture comprehensive information. We then design a Parallel Attention Module (PAM) to enhance model's attention to boundaries, and a Balancing Weight Module (BWM) to facilitate the continuous refinement of boundary segmentation in the bottom-up process. Experiments on five polyp segmentation datasets demonstrate that MISNet successfully improved the accuracy and clarity of segmentation result, outperforming state-of-the-art methods.

Chinese sequence labeling tasks are heavily reliant on accurate word boundary demarcation. Although current pre-trained language models (PLMs) have achieved substantial gains on these tasks, they rarely explicitly incorporate boundary information into the modeling process. An exception to this is BABERT (Jiang et al., 2022), which incorporates unsupervised statistical boundary information into Chinese BERT's pre-training objectives. Building upon this approach, we input supervised high-quality boundary information to enhance BABERT's learning, developing a semi-supervised boundary-aware PLM. To assess PLMs' ability to encode boundaries, we introduce a novel "Boundary Information Metric" that is both simple and effective. This metric allows comparison of different PLMs without task-specific fine-tuning. Experimental results on Chinese sequence labeling datasets demonstrate that the improved BABERT variant outperforms the vanilla version, not only on these tasks but also more broadly across a range of Chinese natural language understanding tasks. Additionally, our proposed metric offers a convenient and accurate means of evaluating PLMs' boundary awareness.

Optical Coherence Tomography Angiography (OCTA) is a non-invasive imaging technique that provides high-resolution cross-sectional images of the retina, which are useful for diagnosing and monitoring various retinal diseases. However, manual segmentation of OCTA images is a time-consuming and labor-intensive task, which motivates the development of automated segmentation methods. In this paper, we propose a novel multi-task learning method for OCTA segmentation, called OCTA-MTL, that leverages an image-to-DT (Distance Transform) branch and an adaptive loss combination strategy. The image-to-DT branch predicts the distance from each vessel voxel to the vessel surface, which can provide useful shape prior and boundary information for the segmentation task. The adaptive loss combination strategy dynamically adjusts the loss weights according to the inverse of the average loss values of each task, to balance the learning process and avoid the dominance of one task over the other. We evaluate our method on the ROSE-2 dataset its superiority in terms of segmentation performance against two baseline methods: a single-task segmentation method and a multi-task segmentation method with a fixed loss combination.

Boundary information is critical for various Chinese language processing tasks, such as word segmentation, part-of-speech tagging, and named entity recognition. Previous studies usually resorted to the use of a high-quality external lexicon, where lexicon items can offer explicit boundary information. However, to ensure the quality of the lexicon, great human effort is always necessary, which has been generally ignored. In this work, we suggest unsupervised statistical boundary information instead, and propose an architecture to encode the information directly into pre-trained language models, resulting in Boundary-Aware BERT (BABERT). We apply BABERT for feature induction of Chinese sequence labeling tasks. Experimental results on ten benchmarks of Chinese sequence labeling demonstrate that BABERT can provide consistent improvements on all datasets. In addition, our method can complement previous supervised lexicon exploration, where further improvements can be achieved when integrated with external lexicon information.

Quantitative assessment of the abdominal region from clinically acquired CT scans requires the simultaneous segmentation of abdominal organs. Thanks to the availability of high-performance computational resources, deep learning-based methods have resulted in state-of-the-art performance for the segmentation of 3D abdominal CT scans. However, the complex characterization of organs with fuzzy boundaries prevents the deep learning methods from accurately segmenting these anatomical organs. Specifically, the voxels on the boundary of organs are more vulnerable to misprediction due to the highly-varying intensity of inter-organ boundaries. This paper investigates the possibility of improving the abdominal image segmentation performance of the existing 3D encoder-decoder networks by leveraging organ-boundary prediction as a complementary task. To address the problem of abdominal multi-organ segmentation, we train the 3D encoder-decoder network to simultaneously segment the abdominal organs and their corresponding boundaries in CT scans via multi-task learning. The network is trained end-to-end using a loss function that combines two task-specific losses, i.e., complete organ segmentation loss and boundary prediction loss. We explore two different network topologies based on the extent of weights shared between the two tasks within a unified multi-task framework. To evaluate the utilization of complementary boundary prediction task in improving the abdominal multi-organ segmentation, we use three state-of-the-art encoder-decoder networks: 3D UNet, 3D UNet++, and 3D Attention-UNet. The effectiveness of utilizing the organs' boundary information for abdominal multi-organ segmentation is evaluated on two publically available abdominal CT datasets. A maximum relative improvement of 3.5% and 3.6% is observed in Mean Dice Score for Pancreas-CT and BTCV datasets, respectively.

The evolution of language follows the rule of gradual change. Grammar, vocabulary, and lexical semantic shifts take place over time, resulting in a diachronic linguistic gap. As such, a considerable amount of texts are written in languages of different eras, which creates obstacles for natural language processing tasks, such as word segmentation and machine translation. Although the Chinese language has a long history, previous Chinese natural language processing research has primarily focused on tasks within a specific era. Therefore, we propose a cross-era learning framework for Chinese word segmentation (CWS), CROSSWISE, which uses the Switch-memory (SM) module to incorporate era-specific linguistic knowledge. Experiments on four corpora from different eras show that the performance of each corpus significantly improves. Further analyses also demonstrate that the SM can effectively integrate the knowledge of the eras into the neural network.