Drug repositioning aims to identify potential new indications for existing drugs to reduce the time and financial costs associated with developing new drugs. Most existing deep learning-based drug repositioning methods predominantly utilize graph-based representations. However, graph-based drug repositioning methods struggle to perform effective inference in cold-start scenarios involving novel drugs because of the lack of association information with the diseases. Unlike traditional graph-based approaches, we propose a bidirectional behavior learning strategy for drug repositioning, known as BiBLDR. This innovative framework redefines drug repositioning as a behavior sequential learning task to capture drug-disease interaction patterns. First, we construct bidirectional behavioral sequences based on drug and disease sides. The consideration of bidirectional information ensures a more meticulous and rigorous characterization of the behavioral sequences. Subsequently, we propose a two-stage strategy for drug repositioning. In the first stage, we construct prototype spaces to characterize the representational attributes of drugs and diseases. In the second stage, these refined prototypes and bidirectional behavior sequence data are leveraged to predict potential drug-disease associations. Based on this learning approach, the model can more robustly and precisely capture the interactive relationships between drug and disease features from bidirectional behavioral sequences. Extensive experiments demonstrate that our method achieves state-of-the-art performance on benchmark datasets. Meanwhile, BiBLDR demonstrates significantly superior performance compared to previous methods in cold-start scenarios. Our code is published in https://github.com/Renyeeah/BiBLDR.

Recent research efforts have investigated how to integrate Large Language Models (LLMs) into recommendation, capitalizing on their semantic comprehension and open-world knowledge for user behavior understanding. These approaches predominantly employ supervised fine-tuning on single-domain user interactions to adapt LLMs for specific recommendation tasks. However, they typically encounter dual challenges: the mismatch between general language representations and domain-specific preference patterns, as well as the limited adaptability to multi-domain recommendation scenarios. To bridge these gaps, we introduce CPRec -- an All-domain Continual Pre-Training framework for Recommendation -- designed to holistically align LLMs with universal user behaviors through the continual pre-training paradigm. Specifically, we first design a unified prompt template and organize users' multi-domain behaviors into domain-specific behavioral sequences and all-domain mixed behavioral sequences that emulate real-world user decision logic. To optimize behavioral knowledge infusion, we devise a Warmup-Stable-Annealing learning rate schedule tailored for the continual pre-training paradigm in recommendation to progressively enhance the LLM's capability in knowledge adaptation from open-world knowledge to universal recommendation tasks. To evaluate the effectiveness of our CPRec, we implement it on a large-scale dataset covering seven domains and conduct extensive experiments on five real-world datasets from two distinct platforms. Experimental results confirm that our continual pre-training paradigm significantly mitigates the semantic-behavioral discrepancy and achieves state-of-the-art performance in all recommendation scenarios. The source code will be released upon acceptance.

Social learning, a cornerstone of cultural evolution, enables individuals to acquire knowledge by observing and imitating others. At the heart of its efficacy lies episodic memory, which encodes specific behavioral sequences to facilitate learning and decision-making. This study explores the interrelation between episodic memory and social learning in collective foraging. Using Sequential Episodic Control (SEC) agents capable of sharing complete behavioral sequences stored in episodic memory, we investigate how variations in the frequency and fidelity of social learning influence collaborative foraging performance. Furthermore, we analyze the effects of social learning on the content and distribution of episodic memories across the group. High-fidelity social learning is shown to consistently enhance resource collection efficiency and distribution, with benefits sustained across memory lengths. In contrast, low-fidelity learning fails to outperform nonsocial learning, spreading diverse but ineffective mnemonic patterns. Novel analyses using mnemonic metrics reveal that high-fidelity social learning also fosters mnemonic group alignment and equitable resource distribution, while low-fidelity conditions increase mnemonic diversity without translating to performance gains. Additionally, we identify an optimal range for episodic memory length in this task, beyond which performance plateaus. These findings underscore the critical effects of social learning on mnemonic group alignment and distribution and highlight the potential of neurocomputational models to probe the cognitive mechanisms driving cultural evolution.

As we move closer to real-world AI systems, AI agents must be able to deal with multiparty (group) conversations. Recognizing and interpreting multiparty behaviors is challenging, as the system must recognize individual behavioral cues, deal with the complexity of multiple streams of data from multiple people, and recognize the subtle contingent social exchanges that take place amongst group members. To tackle this challenge, we propose the Multiparty-Transformer (Multipar-T), a transformer model for multiparty behavior modeling. The core component of our proposed approach is the Crossperson Attention, which is specifically designed to detect contingent behavior between pairs of people. We verify the effectiveness of Multipar-T on a publicly available video-based group engagement detection benchmark, where it outperforms state-of-the-art approaches in average F-1 scores by 5.2% and individual class F-1 scores by up to 10.0%. Through qualitative analysis, we show that our Crossperson Attention module is able to discover contingent behavior.

An essential topic in online social network security is how to accurately detect bot accounts and relieve their harmful impacts (e.g., misinformation, rumor, and spam) on genuine users. Based on a real-world data set, we construct behavioral sequences from raw event logs. After extracting critical characteristics from behavioral time series, we observe differences between bots and genuine users and similar patterns among bot accounts. We present a novel social bot detection system BotShape, to automatically catch behavioral sequences and characteristics as features for classifiers to detect bots. We evaluate the detection performance of our system in ground-truth instances, showing an average accuracy of 98.52% and an average f1-score of 96.65% on various types of classifiers. After comparing it with other research, we conclude that BotShape is a novel approach to profiling an account, which could improve performance for most methods by providing significant behavioral features.

Researchers at the University of Utah Health have used machine learning to start making links between seemingly instinctive, random behaviors and the genetic factors that shape such behaviors. Using machine learning to study mice with differences in their genetics and age, the team found that these differences influenced the behavioral sequences the animals expressed while they foraged for food. The researchers believe the methodology could one day be applied to help understand the genomic elements that may shape complex behaviors in humans, including those that lead to disease or psychiatric disorders. Patterns of complex behavior, like searching for food, are composed of sequences that feel random, spontaneous and free. Using machine learning, we are finding discrete sequences that are reproduced more frequently than you would expect by chance and these sequences are rooted in biology." Gregg and colleagues are venturing into what has previously been considered a controversial new territory called behavioral sequencing. The aim is to understand the architecture of complex behavior and how genetics shape these patterns. The concerns surrounding behavioral genetics research are based on fears that it could lead to eugenic policies. Literally meaning "well-born," eugenics refers to the improvement of humanity using scientific methods such as selective breeding. As outlined by the Nuffield Council on Bioethics, the use of "negative eugenics" has led to some of the worst atrocities in recent history such as the segregation and sterilization of hundreds of thousands of people in the United States and Europe. However, members of the council point out that contemporary research into the area is not necessarily pursuing eugenics-based goals and that the devastating events that have occurred in the past could be learned from to prevent such abuse in the future. The council acknowledges that there are certain concerns that need to be addressed if research into the field is going to be encouraged. Defining and measuring behaviors can be challenging and there is a risk of misinterpreting or misapplying statistical estimates of heritability. Other concerns include the lack of replicated findings and difficulties in predicting how behavior develops, given how complex the interaction between genes and the environment is. However, the council concludes that despite these concerns, identifying and investigating the genes that influence behavior is still practicable and worthwhile. "There are currently no practical applications of research in the genetics of behavior within the normal range.

We present a novel connectionist model for acquiring the semantics of a simple language through the behavioral experiences of a real robot. We focus on the "compositionality" of semantics, a fundamental characteristic of human language, which is the ability to understand the meaning of a sentence as a combination of the meanings of words. We also pay much attention to the "embodiment" of a robot, which means that the robot should acquire semantics which matches its body, or sensory-motor system. The essential claim is that an embodied compositional semantic representation can be self-organized from generalized correspondences between sentences and behavioral patterns. This claim is examined and confirmed through simple experiments in which a robot generates corresponding behaviors from unlearned sentences by analogy with the correspondences between learned sentences and behaviors.

We present a novel connectionist model for acquiring the semantics of a simple language through the behavioral experiences of a real robot. We focus on the "compositionality" of semantics, a fundamental characteristic of human language, which is the ability to understand the meaning of a sentence as a combination of the meanings of words. We also pay much attention to the "embodiment" of a robot, which means that the robot should acquire semantics which matches its body, or sensory-motor system. The essential claim is that an embodied compositional semantic representation can be self-organized from generalized correspondences between sentences and behavioral patterns. This claim is examined and confirmed through simple experiments in which a robot generates corresponding behaviors from unlearned sentences by analogy with the correspondences between learned sentences and behaviors.

We present a novel connectionist model for acquiring the semantics of a simple language through the behavioral experiences of a real robot. We focus on the "compositionality" of semantics, a fundamental characteristic ofhuman language, which is the ability to understand the meaning of a sentence as a combination of the meanings of words. We also pay much attention to the "embodiment" of a robot, which means that the robot should acquire semantics which matches its body, or sensory-motor system. The essential claim is that an embodied compositional semantic representation can be self-organized from generalized correspondences between sentences and behavioral patterns. This claim is examined and confirmed through simple experiments in which a robot generates corresponding behaviorsfrom unlearned sentences by analogy with the correspondences betweenlearned sentences and behaviors.